PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

  • Products and Services

  • Resources, Events & More

Narrow your results
Product Type
  • Consumables (2)
  • Instruments (7)
  • Reagents (535)
Target Species
  • Human (10)
Application
  • cAMP (26)
  • Drug Discovery & Development (337)
  • Mobility Shift (36)
  • Plant Sciences (1)
  • Protein Analysis & Detection (5)
  • Protein-protein interactions (4)
  • Radiometric (4)
Therapeutic Area
  • Angiogenesis (27)
  • Biologics/Bioprocess (2)
  • Cancer (22)
  • Cardiovascular (118)
  • Central Nervous System (97)
  • CNS & Neurologic (125)
  • Diabetes (20)
  • Gastrointestinal (75)
  • Immune (3)
  • Inflammation (138)
  • Metabolic (52)
  • Metabolic Disorders (42)
  • Musculoskeletal (1)
  • Obesity (9)
  • Pain (72)
  • Parasympathetic Nervous System (5)
  • Renal (2)
  • Sympathetic Nervous System (2)
Product Brand Name
  • AequoScreen (2)
  • AequoZen (3)
  • AlphaLISA (3)
  • cAMPZen (1)
  • DELFIA (4)
  • LabChip EZ Reader (50)
  • Membrane Target Systems (112)
  • MicroBeta (2)
  • NEN Radiochemicals (116)
  • NEN Radiolabeled Ligands (76)
  • OmniFilter (1)
  • SPA Imaging Beads (18)
  • SPA Scintillation Beads (26)
  • UniFilter (7)
  • ValiScreen (75)
Color
  • White (4)
Coating Treatment
  • Anti-mouse antibody (2)
  • Anti-mouse IgG (2)
  • Anti-rabbit antibody (2)
  • Anti-rabbit IgG (2)
  • Copper (HIS-tag) (2)
  • Copper chelate (2)
  • Glutathione (4)
  • HIS (2)
  • Nickel chelate (HIS-tag) (2)
  • PDE (2)
  • PEI (14)
  • Poly-L-lysine (2)
  • Poly-lysine (5)
  • Protein A (2)
  • RNA Binding (1)
  • Streptavidin (13)
  • Uncoated (1)
  • WGA (17)
  • WGA PEI type A (1)
  • WGA PEI Type B (1)
Material
  • Barex/GF/B (1)
  • Barex/GF/C (1)
  • Polystyrene/GF/B (1)
  • Polystyrene/GF/C (1)
Detection Method
  • Alpha (3)
  • DELFIA TRF (4)
  • Filtration (4)
  • Fluorescence (1)
  • Radiometric (252)
  • Time-Resolved Fluorescence (TRF) (4)
Receptor Type
  • 5-Hydroxytryptamine (12)
  • 5-Hydroxytryptamine (Serotonin) (23)
  • Acetylcholine (1)
  • Acetylcholine (Muscarinic) (16)
  • Adenosine (14)
  • Adrenergic (13)
  • Adrenoceptors (10)
  • Anaphylatoxin (4)
  • Angiotensin (9)
  • Apelin (2)
  • Benzodiazepine (6)
  • Bombesin (5)
  • Bradykinin (4)
  • Calcitonin (6)
  • Calcium (6)
  • Cannabinoid (8)
  • Chemokine (15)
  • Cholecystokinin (5)
  • Corticotropin-Releasing Factor (1)
  • Dopamine (20)
  • Dopamine Transporter (2)
  • Endothelin (3)
  • Epidermal Growth Factor (2)
  • Formyl Peptide (2)
  • Free Fatty Acid (2)
  • GABA (4)
  • GABAA (6)
  • GABAB (1)
  • Galanin (5)
  • Ghrelin (4)
  • Glucagon (6)
  • Glutamate (7)
  • Glycine (4)
  • Gonadotropin-releasing Hormone (1)
  • Growth Hormone (1)
  • hERG (3)
  • Histamine (9)
  • Insulin (3)
  • Insulin-like Growth Factor (1)
  • Interleukin (1)
  • Leukotriene (3)
  • Melanin-Concentrating Hormone (1)
  • Melanocortin (13)
  • Melatonin (2)
  • Metastin (1)
  • Motilin (1)
  • Muscarinic (10)
  • Neuromedin U (3)
  • Neuropeptide (7)
  • Neuropeptide Y (3)
  • Neurotensin (6)
  • Nicotinic (8)
  • NMDA (1)
  • Norephinephrine (1)
  • Norepinephrine (2)
  • Opioid (19)
  • Orexin (4)
  • Oxytocin (2)
  • Peptide P518 (1)
  • Platelet-Derived Growth Factor (1)
  • Potassium (2)
  • Progestin (1)
  • Prokineticin (1)
  • Prolactin Releasing Peptide (2)
  • Prostanoid (9)
  • Purinergic P2Y (2)
  • Relaxin (3)
  • Retinoic Acid Receptors (1)
  • Serotonin (4)
  • SK channels (1)
  • Somatostatin (11)
  • SVCT1 (1)
  • SVCT2 (1)
  • Tachykinin (7)
  • Thyroid Hormone (3)
  • Thyrotropin Releasing Hormone (1)
  • Thyrotropin-releasing Hormone (2)
  • Transforming Growth Factor (1)
  • TRPC5 (1)
  • Urotensin (2)
  • Vasoactive Intestinal Peptide (3)
  • Vasopressin (12)
  • Vesicular Amine Transporters (VATs) (1)
Assay Validated
  • Binding (210)
  • Calcium Fluorescence (21)
  • Calcium Luminescence (5)
  • cAMP (56)
  • Downstream Phosphorylation (1)
  • GTPγS (53)
  • Inositol Phosphate (15)
Sample Type
  • Enzyme (38)
Radioisotope
  • C-14 (6)
  • H-3 (112)
  • I-125 (78)
  • S-35 (1)
Radionuclide
  • 125I (78)
  • 14C (5)
  • 35S (1)
  • 3H (1)
  • 3H (111)
Fluorophore
  • Eu-N1-ITC (2)
Label Position
  • Generally Labeled (6)
  • Nominally Labeled (98)
  • Specifically Labeled (92)
  • Uniformly Labeled (1)
Assay points(200-50,000)
  • 500 (2)
  • 5000 (2)
Assay Target Class
  • GPCR (180)
  • Ion channel (2)
  • Transporter (6)
  • Tyrosine Kinase Receptor (1)
Automation Compatible
  • No (20)
  • Yes (44)
Concentration
  • 1 mCi/mL (4)
  • 1.0 - 10 mCi/mL (59)
  • 1.0 - 10 µCi/mL (3)
  • 1.12 mCi/mL (1)
  • 1.14 mCi/mL (1)
  • 152 µCi/mL (1)
  • 170.1 µCi/mL (1)
  • 171 µCi/mL (1)
  • 172.5 µCi/mL (1)
  • 173.9 µCi/mL (1)
  • 182 µCi/mL (2)
  • 2.93 MBq/mL (1)
  • 236 µCi (1)
  • 3.06 MBq/mL (1)
  • 3.22 MBq/mL (1)
  • 33.7 µCi (1)
  • 345 µCi/mL (3)
  • 353 µCi/mL (3)
  • 41.4 µCi/mL (2)
  • 42.5 µCi/mL (1)
  • 45.7 µCi/mL (1)
  • 50 µCi/mL (1)
  • 6.05 MBq/mL (1)
  • 79.2 µCi/mL (2)
  • 83.8 µCi/mL (1)
  • 85.1 µCi/mL (1)
  • 87.2 µCi/mL (1)
  • 87.4 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • 87.9 µCi/mL (1)
  • 88.5 µCi/mL (1)
  • 93.2 µCi/mL (1)
  • <1.0 mCi/mL (7)
  • <1.0 µCi/mL (3)
  • <100 µCi/mL (1)
Experimental Type
  • In vitro (4)
Format
  • Microplates (19)
  • Tubes (11)
Host Cell
  • 1321N1 (11)
  • A431 (1)
  • A9 (1)
  • CHO-DHFR(-) (1)
  • CHO-K1 (134)
  • HEK293 (38)
  • HT29 (1)
  • K562 (1)
  • L Cells (1)
  • MDA-MB-435S (1)
  • MDCK (2)
  • U373 (1)
  • UC11 (1)
Length
  • 51-100 (6)
Number of Wells
  • 96 (4)
Volume
  • 0-50 (45)
  • 51-100 (1)
  • 201-250 (58)

"Receptor Ligand Binding" 1-50 of 544 Products and Services

Sort
Per Page

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.
Alpha Bungarotoxin

Iodo-(±)-Cyanopindolol, [125I]

Iodo-(±)-cyanopindolol, labeled with 125I. Cyanopindolol acts as an antagonist at β1 adrenergic receptors and serotonin 5-HT1A receptors.
Price Range : 1505.00 EUR - 3362.00 EUR
Receptor-expressing cell lines

ValiScreen Calcitonin CGRP1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 2, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
List Price : 1432.00 EUR
Adenosine 5 Triphosphate 250 µCi

MDL105,519, [3H]

Tritiated MDL 105,519. MDL 105,519 acts as a potent and selective antagonist at N-methyl-D-aspartate (NMDA) receptors.
List Price : 3064.00 EUR
PerkinElmer

ProfilerPro Kinase Peptide Substrate 18, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 18 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 665.00 EUR
Adenosine 5 Triphosphate 250 µCi

5-Hydroxytryptamine Creatinine Sulfate, [1,2-3H(N)]

5-Hydroxytryptamine Creatinine Sulfate (Serotonin, 5-HT), tritiated at the 1,2 position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.
Price Range : 853.00 EUR - 2303.00 EUR
Adenosine 5 Triphosphate 250 µCi

Norepinephrine, Levo-[ring-2,5,6-3H]

Levo-Norepinephrine, tritiated on the ring group. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).
Price Range : 1516.00 EUR - 9700.00 EUR
Receptor-expressing cell lines

ValiScreen Serotonin 5HT-1A (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

Raclopride, [Methoxy-3H]

Raclopride, [Methoxy-3H]- will have fresh lot dates on the second Monday in March and September.
Price Range : 638.00 EUR - 5100.00 EUR
Adenosine 5 Triphosphate 250 µCi

Muscimol, 3-Hydroxy-5-Aminomethylisoxazole, [Methylene-3H(N)]

3H Muscimol radioligand. Muscimol acts as a potent selective agonist at GABAA receptors. It also acts as a partial agonist at GABAA-rho receptors. This product has a scheduled lot release for the second Monday in February and August. NOTE: NET574001MC will be obsolete soon.
List Price : 2003.00 EUR
PerkinElmer

ProfilerPro Kinase Peptide Substrate 26, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 26 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 665.00 EUR
PerkinElmer

Streptavidin PS Imaging Beads 500 MG

Streptavidin-coated SPA beads, for capturing biotinylated molecules in proximity-based scintillation assays.
List Price : 1358.00 EUR
Receptor-expressing cell lines

ValiScreen Somatostatin sst4 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

LH-RH, [125I]-[D-Trp6]

Luteinizing Hormone Releasing Hormone (LHRH), labeled with 125I. LHRH binds LHRH receptors, and is a drug target for cancer therapy.
Price Range : 1197.00 EUR - 3192.00 EUR
Receptor-expressing cell lines

ValiScreen TRH (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

2'-deoxycytidine-5'-triphosphate, 5-[125I]Iodo-

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
List Price : 1996.00 EUR
Alpha Bungarotoxin

Thyroxine, ([125I]-T4), 5700 µCi/µg

Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 1031.00 EUR - 3029.00 EUR
PerkinElmer

Membrane Target Systems: GABA B1a in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1a receptor, 400 units.
List Price : 823.00 EUR
Alpha Bungarotoxin

Neurotensin, [125I]Tyr3]

Neurotensin, labeled with 125I on the tyrosine 3 residue. Neurotensin functions as an agonist at neurotensin receptors. It is known to induce analgesia, hypothermia and increased locomotor activity. Neurotensin is also involved in the regulation of dopamine.
Price Range : 1150.00 EUR - 2403.00 EUR
PerkinElmer

Membrane Target Systems: Cannabinoid CB2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Cannabinoid CB2 receptor, in HEK-293 cells.
List Price : 823.00 EUR
Adenosine 5 Triphosphate 250 µCi

Kainic acid, [Isopropenyl-3H]

Kainic acid, tritiated on the isoproprenyl group. Kainic acid acts as an agonist at kainate glutamate receptors.
Price Range : 649.00 EUR - 6000.00 EUR
PerkinElmer

Membrane Target Systems: Vasopressin V1b (human) membrane preparation, in 1321N1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR
Adenosine 5 Triphosphate 250 µCi

Lysergic Acid Diethylamide, [N-Methyl-3H]-, 250µCi (9.25MBq)

Lysergic Acid Diethylamide (LSD), tritiated on the N-methyl group. LSD is a partial agonist of dopamine D2 receptors. It also binds most serotonin receptors (5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT5B and 5-HT6). This product has a scheduled lot release for the second Monday in April, August and December.
List Price : 2253.00 EUR
Receptor-expressing cell lines

Dopamine D1 (human) ValiScreen® cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

DELFIA Eu-Labeling kit (Eu-N1-ITC chelate), 0.2mg

DELFIA® Europium labeling kit for labeling your own biomolecules for use in DELFIA time-resolved fluorescence assays. The ITC chelate reacts with free amine groups in the target biomolecule.
List Price : 476.00 EUR
PerkinElmer

Streptavidin YSI 75MG

Streptavidin-coated SPA beads, for capturing biotinylated biomolecules in proximity-based radiometric scintillation assays.
List Price : 760.00 EUR
Alpha Bungarotoxin

Gastric Inhibitory Polypeptide (human), [125I]

Gastric inhibitor polypeptide (GIP), labeled with 125I. GIP is a hormone that binds receptors found on beta cells in the pancreas.
Price Range : 1079.00 EUR - 2067.00 EUR
PerkinElmer

Membrane Target Systems: Serotonin 5HT-2A (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 823.00 EUR
Receptor-expressing cell lines

ValiScreen Muscarinic M1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

ValiScreen Prostanoid FP (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 14, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 14 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 665.00 EUR
Receptor-expressing cell lines

ValiScreen Relaxin RXFP3 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

Norepinephrine, Levo-[7-3H]

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET). This product has a scheduled lot release for the third Monday in July.
Price Range : 1367.00 EUR - 10400.00 EUR
Receptor-expressing cell lines

ValiScreen Somatostatin sst1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

Strychnine, [Benzene-Ring-3H]-, 250µCi (9.25MBq)

Strychnine, tritiated on the benzene ring. Strychnine acts as an antagonist at glycine and acetylcholine receptors.
List Price : 2797.00 EUR
Adenosine 5 Triphosphate 250 µCi

RO 15-4513, [7,9-3H]-, 250µCi (9.25MBq)

Ro15-4513, tritiated at the 7,9 position. Ro15-4513 is a partial inverse agonist at GABAA receptors.
List Price : 2749.00 EUR
Adenosine 5 Triphosphate 250 µCi

Deltorphin II (2-D-Ala), [Tyrosyl-3,5-3H]

Deltorphin II, tritiated at the tyrosyl-3,5 position. Deltorphin II is a selective δ opioid receptor (DOPR) agonist.
Price Range : 1043.00 EUR - 4421.00 EUR
Alpha Bungarotoxin

2`-Deoxycytidine-5`-triphosphate, 5-[125I] iodo-, Tetraammonium Salt

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
Price Range : 1254.00 EUR - 3136.00 EUR
Alpha Bungarotoxin

Apelin 13 [125I]

Apelin, labeled with 125 I. Apelin is the endogenous ligand for apelin receptors, and is used in receptor binding studies. Apelin 13 is a 13-amino acid peptide corresponding to residues 65-77.
Price Range : 1142.00 EUR - 3976.00 EUR
Alpha Bungarotoxin

IL-6 (human, recombinant), [125I]

Interleukin 6 (IL-6), labeled with 125I. IL-6 is a cytokine that regulates cell growth, cell differentiation, and immune response, and binds to the interleukin 6 receptor (IL6R; CD126).
Price Range : 1475.00 EUR - 4935.00 EUR
Adenosine 5 Triphosphate 250 µCi

Escitalopram, [N-methyl-3H]-

Escitalopram (Cipralex), tritiated at the N-methyl position. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with high selectivity for the serotonin transporter (SERT) compared to the norepinephrine transporter (NET).
List Price : 5100.00 EUR
Adenosine 5 Triphosphate 250 µCi

Astemizole, [O-Methyl-3H]

Astemizole (Hismanal) tritiated at the O-methyl group. Atemizole is an antagonist of the histamine H1-receptor and has been shown to block hERG potassium channels.
Price Range : 801.00 EUR - 8000.00 EUR
PerkinElmer

Membrane Target Systems: Chemoattractant C5a (human varient) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human chemoattractant C5a (human varient) receptor, 400 units.
List Price : 823.00 EUR

"Receptor Ligand Binding" 1-50 of 544 Products and Services

Per Page