PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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Radionuclide
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Radioisotope
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"Receptor Ligand Binding" 1-50 of 545 Products and Services

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UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.
PerkinElmer

Membrane Target Systems: Serotonin 5HT-6 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Leukotriene BLT1 (LTB4R1) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Relaxin RXFP4 (GPCR142) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 867.00 USD

Neurokinin A, ([125I]-Substance K

Neurokinin A (Substance K), labeled with 125I. Neurokinin A is a member of the tachykinin family of neuropeptide neurotransmitters, and is an endogenous agonist for NK-2 receptors. NK-2 receptors are potential drug targets for depression.
Price Range : 818.00 USD - 1966.00 USD

Thyroxine, ([125I]-T4), Specific Activity: 1080-1320 µCi/µg

Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 764.00 USD - 2513.00 USD
PerkinElmer

Membrane Target Systems: Somatostatin sst3 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Adenosine 5 Triphosphate 250 µCi

17α-HYDROXYPROGESTERONE, [1,2,6,7-3H]

17α-Hydroxyprogesterone (17α-OHP), tritiated at the 1,2,6,7 position. 17α-Hydroxyprogesterone is an agonist of the progesterone receptor (PR), an antagonist of the mineralocorticoid receptor (MR), and a partial agonist of the glucocorticoid receptor.
List Price : 1476.00 USD
Receptor-expressing cell lines

ValiScreen Bradykinin B1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

DELFIA® L*R binding buffer concentrate (10x), 250 mL

Buffer for DELFIA® time-resolved fluorescence (TRF) ligand binding assays.
List Price : 548.00 USD
PerkinElmer

Membrane Target Systems: Orexin OX1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Receptor-expressing cell lines

ValiScreen Serotonin 5HT-6 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

α-Bungarotoxin, [125I]-Tyr54

α-bungarotoxin, labeled with 125I on tyrosine residue 54. α-bungarotoxin is a snake venom neurotoxin that acts as an antagonist at nicotinic acetylcholine receptors (nAChRs). This product as offered at two specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available). This indicates that virtually every molecule of ligand provided in the stock vial is radiolabeled.
Price Range : 566.00 USD - 2527.00 USD
Adenosine 5 Triphosphate 250 µCi

Kainic acid, [Isopropenyl-3H]

Kainic acid, tritiated on the isoproprenyl group. Kainic acid acts as an agonist at kainate glutamate receptors.
Price Range : 568.00 USD - 5300.00 USD
Receptor-expressing cell lines

Melanin concentrating hormone (MCH1) receptor (human recombinant) AequoZen Frozen Cells

Our frozen, irradiated AequoZen cells express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
List Price : 765.00 USD
Adenosine 5 Triphosphate 250 µCi

Ketanserin Hydrochloride (R41 468), [Ethylene-3H]

Ketanserin hydrochloride (Sufrexal; R41468), tritiated on the ethylene group. Ketanserin is a high-affinity non-selective antagonist of 5-HT2 receptors.
Price Range : 614.00 USD - 5500.00 USD

Pancreatic Polypeptide (human), [125I]

Human pancreatic polypeptide (PP), labeled with 125I. Pancreatic polypeptide acts as an agonist at Pancreatic polypeptide receptors (Neuropeptide Y receptors), a class of GPCRs involved in appetite, circadian rhythm, and anxiety.
Price Range : 1011.00 USD - 2288.00 USD
PerkinElmer

LabChip Sipper Chip Coating Reagent 3 (35 ml), for EZ Reader

CR-3, or Coating Reagent 3, is an essential component in separation buffer that coats the inner channels of a microfluidic chip to prevent the adsorption and build-up of substrate peptides and other assay components. CR-3 is already present in ProfilerPro Separation Buffer (#760367) at a concentration of 0.1% and does NOT need to be added to Separation Buffer unless you are making your own formulation.
List Price : 222.00 USD
Receptor-expressing cell lines

ValiScreen Relaxin RXFP3 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

STREP PVT SPECIAL 25 X 500 MG

Streptavidin-coated SPA beads, for capturing biotinylated biomolecules in proximity-based radiometric scintillation assays.
List Price : 63300.00 USD
Receptor-expressing cell lines

ValiScreen Leukotriene BLT1 (LTB4R1) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

Histamine Dihydrochloride, [Ring, Methylenes-3H(N)]

Histamine dihydrochloride, tritiated on the ring and methylene groups. Histamine is an endogenous agonist of histamine receptors.
Price Range : 1080.00 USD - 2349.00 USD

Iodo-Melatonin, 2-[125I]

Melatonin, labeled with 125I. Melatonin binds and activates melatonin receptors, a class of GPCRs that are potential drug targets for circadian rhythm sleep disorders and depression.
Price Range : 988.00 USD - 2498.00 USD

Insulin-like Growth Factor-I (human, recombinant), 125I

Insulin-like growth factor 1 (IGF-1), labeled with 125I. IGF-1 acts as an agonist at the IGF-1 receptor, a receptor tyrosine kinase, that plays a role in growth, cancer, and aging. IGF-1 also binds the insulin receptor (IR), another receptor tyrosine kinase involved in glucose homeostasis, diabetes, and cancer.
Price Range : 675.00 USD - 1656.00 USD

Motilin, [125I]

Motilin, labeled with 125I. Motilin is a peptide hormone that binds motilin receptors, and stimulates contraction of gut smooth muscle.
Price Range : 1153.00 USD - 2319.00 USD

Thyroxine, ([125I]-T4), Specific Activity: 135-165 µCi/µg

Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 651.00 USD - 1816.00 USD

Sauvagine, [125I]-Tyr0]

Sauvagine, labeled with 125I on the tyrosine 0 residue. Sauvagine is a neuropeptide that acts as an agonist at corticotropin-releasing factor receptors (CRF receptors) 1 and 2.
Price Range : 1041.00 USD - 2164.00 USD

DELFIA Eu-Labeling kit (Eu-N1-ITC chelate), 0.2mg

DELFIA® Europium labeling kit for labeling your own biomolecules for use in DELFIA time-resolved fluorescence assays. The ITC chelate reacts with free amine groups in the target biomolecule.
List Price : 541.00 USD
Adenosine 5 Triphosphate 250 µCi

Propranolol, L-[4-3H]-, 250µCi (9.25MBq)

L-propranolol, tritiated at the 4 position. Propranolol is a non-selective beta blocker that acts as a potent antagonist for β-adrenoceptors.
List Price : 1312.00 USD
Receptor-expressing cell lines

ValiScreen Cholecystokinin CCK1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

Verapamil Hydrochloride, [N-Methyl-3H]

Verapamil hydrochloride, tritiated on the N-methyl group. Verapamil acts as a calcium channel blocker (CCB).
Price Range : 680.00 USD - 2571.00 USD
Adenosine 5 Triphosphate 250 µCi

Thyrotropin Releasing Hormone, [L-histidyl-4-3H(N), L-propyl-3,4-3H(N)]

Thyrotropin-releasing hormone (TRH), tritiated on the histidyl and propyl groups. TRH binds and activates thyrotropin-releasing hormone receptors (TRH-Rs).
Price Range : 1642.00 USD - 6000.00 USD
Receptor-expressing cell lines

ValiScreen Angiotensin AT1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

ValiScreen Muscarinic M4 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

PEI PS Imaging Beads 500 MG

PEI-coated SPA beads, for use in scintillation proximity assays.
List Price : 426.00 USD
Receptor-expressing cell lines

ValiScreen Purinergic P2Y6 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Glycerol 3 Phosphate, ammonium salt, L-[14C(U)]-

Iodoantipyrine, 4-[N-Methyl-14C]

4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine has been used to measure cerebral blood flow.
Price Range : 705.00 USD - 5800.00 USD
Receptor-expressing cell lines

Dopamine Transporter (human) Cell Line

Our stable recombinant cell lines express a variety of receptors for binding and functional assays.
List Price : 17800.00 USD
PerkinElmer

Membrane Target Systems: Chemokine CXCR2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Receptor-expressing cell lines

ValiScreen Somatostatin sst4 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

ValiScreen Nicotinic HM74a (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

SB-269970, [3H]

Tritiated SB-269970. SB-269970 is believed to act as a selective serotonin 5-HT7 antagonist, or possibly an inverse agonist.
List Price : 3261.00 USD
Adenosine 5 Triphosphate 250 µCi

Cocaine, Levo-[benzoyl-3,4-3H(N)]-

Cocaine, tritiated at the benzoyl-3,4 position. Cocaine binds and blocks the dopamine transporter, preventing removal of dopamine from synapses in the brain.
List Price : 2890.00 USD
Adenosine 5 Triphosphate 250 µCi

Cytisine HCl, [3,5-3H(N)]

Cytisine HCl, [3,5-3H(N)]- will have fresh lot dates on the second Monday in April.
Price Range : 596.00 USD - 2140.00 USD

"Receptor Ligand Binding" 1-50 of 545 Products and Services

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