PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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"Receptor Ligand Binding" 1-50 of 570 Products and Services

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MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.
Receptor-expressing cell lines

ValiScreen Melanocortin MC4 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), DL-α-[5-Methyl-3H]

DL-α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), tritiated at the 5-methyl position. AMPA acts as an agonist at the AMPA receptor.
Price Range : 567.00 USD - 4183.00 USD
PerkinElmer

Membrane Target Systems: Adrenergic alpha 1A (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

MK-801, (+)-[3-3H]-

(+)-MK-801 radioligand tritriated at the 3 position. MK-801 acts as a non-competitive antagonist at the glutamate receptor, N-Methyl-D-aspartate (NMDA).
Price Range : 648.00 USD - 4555.00 USD
Receptor-expressing cell lines

ValiScreen Melanocortin MC3 (mouse) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Serotonin 5HT-6 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

AH5183, L-[PIPERIDINYL-3,4-3H]-(VESAMICOL), 250 µCi

AH5183 (vesamicol) radioligand tritiated at the piperidinyl-3,4 position. AH5183 is an acetylcholine transport blocker.
List Price : 960.00 USD

Orexin A, [125I]

Orexin A, labeled with 125I. Orexin A binds to orexin receptors (OX1 and OX2), which are potential drug targets for sleep disorders.
Price Range : 926.00 USD - 1987.00 USD
PerkinElmer

Membrane Target Systems: Serotonin 5HT-2C (ne) (human) membrane preparation, in 1321N1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
PerkinElmer

Serotonin Transporter (human) Cell Line

Our stable recombinant cell lines express a variety of receptors for binding and functional assays.
List Price : 17800.00 USD
Receptor-expressing cell lines

ValiScreen Adrenergic beta 3 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Thyrotropin Releasing Hormone, [L-histidyl-4-3H(N), L-propyl-3,4-3H(N)]

Thyrotropin-releasing hormone (TRH), tritiated on the histidyl and propyl groups. TRH binds and activates thyrotropin-releasing hormone receptors (TRH-Rs).
Price Range : 1642.00 USD - 6000.00 USD

SCH 23390, [N-Methyl-3H]

SCH-23390 (halobenzazepine), tritiated on the N-methyl group. SCH-23390 acts as an antagonist at the dopamine D1 receptor.
Price Range : 520.00 USD - 2845.00 USD

Propranolol, L-[4-3H]-, 250µCi (9.25MBq)

L-propranolol, tritiated at the 4 position. Propranolol is a non-selective beta blocker that acts as a potent antagonist for β-adrenoceptors.
List Price : 1312.00 USD

Raclopride, [Methoxy-3H]

Raclopride, tritiated on the methoxy group. Raclopride acts as a selective antagonist at dopamine D2 receptors. This product will have fresh lot dates on the second Monday in March and September in 2018.
Price Range : 558.00 USD - 4457.00 USD
Receptor-expressing cell lines

ValiScreen Adenosine A3 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Ifenprodil, [Phenyl-3H]-, 250µCi (9.25MBq)

Ifenprodil, tritiated on the phenyl group. Ifenprodil acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor.
List Price : 1990.00 USD

PDGF [125I] (human)

NEX433 [125I]-PDGF BB homodimer has been shown to work in RIA and receptor studies, using CHO cell line transfected with human PDGF B receptor, and human artery smooth muscle cells.
Price Range : 935.00 USD - 2103.00 USD
PerkinElmer

Membrane Target Systems: Vasopressin V1b (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Vasopressin V1b receptor, in HEK-293 cells.
List Price : 936.00 USD
Receptor-expressing cell lines

ValiScreen Vasopressin V1b (rat) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 16, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 16 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 721.00 USD

Insulin-like Growth Factor-I (human, recombinant), 125I

Insulin-like growth factor 1 (IGF-1), labeled with 125I. IGF-1 acts as an agonist at the IGF-1 receptor, a receptor tyrosine kinase, that plays a role in growth, cancer, and aging. IGF-1 also binds the insulin receptor (IR), another receptor tyrosine kinase involved in glucose homeostasis, diabetes, and cancer.
Price Range : 675.00 USD - 1656.00 USD

Ryanodine, [9,21-3H(N)]-, 250µCi (9.25MBq)

Ryanodine, tritiated at the 9,21 position. Ryanodine is a natural ligand for the ryanodinen receptor.
List Price : 2295.00 USD

PK 11195, [N-Methyl-3H]

PK-11195, tritiated on the N-methyl group. PK-11195 binds selectively to the peripheral benzodiazepine receptor (PBR).
Price Range : 606.00 USD - 4478.00 USD

GR113808,[N-methyl-3H]-

GR113808, tritiated on the N-methyl group. GR113808 acts as a selective antagonist at the 5-HT4 receptor.
List Price : 4070.00 USD

DTG (1,3-Di-o-tolylguanidine, [p-ring-3H]-), [5-3H(N)]

DTG (Ditolylguanidine), tritiated on the p-ring and at the 5- position. DTG is a selective sigma receptor (σ-receptor) agonist.
Price Range : 2171.00 USD - 5500.00 USD

Nicotine, L-(-)-[N-Methyl-3H]

Nicotine radioligand tritiated on the methyl residue. Nicotine acts as an agonist at most nicotinic acetylcholine receptors; however it acts as an antagonist at two nicotinic receptor subunits (nAChRα9 and (nAChRα10). 
Price Range : 499.00 USD - 3850.00 USD

Iodoantipyrine, 4-[N-Methyl-14C]

4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine has been used to measure cerebral blood flow.
Price Range : 705.00 USD - 5800.00 USD
Receptor-expressing cell lines

ValiScreen Adenosine A2b (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Fractalkine (human, recombinant), 125I

Fractalkine (CX3CL1), labeled with 125I. Fractalkine binds to chemokine receptor CX3CR1, and is involved in the adhesion and migration of leukocytes.
Price Range : 959.00 USD - 2117.00 USD

TGF-β1 (human, recombinant), [125I]

Transforming growth factor beta 1 (TGF-β1), labeled with 125I. TGF-β1 is a cytokine that is involved in cell growth, cell differentiation, and apoptosis.
Price Range : 845.00 USD - 2117.00 USD
PerkinElmer

WGA YSI 250MG

WGA-coated SPA beads, for capturing cell membranes in proximity-based radiometric scintillation assays.
List Price : 831.00 USD

Thyroxine, ([125I]-T4), Specific Activity: 1080-1320 µCi/µg

Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 764.00 USD - 2513.00 USD

(+)-Pentazocine, [Ring-1,3-3H]

(+)-Pentazocine radioligand tritiated at the 1,3 position on the ring. Pentazocine is a synthetic opioid shown to bind sigma 1 receptor.
Price Range : 621.00 USD - 4846.00 USD

Iodo-(-)-Cyanopindolol, [125I]

Iodo-(-)-cyanopindolol, labeled with 125I. Cyanopindolol acts as an antagonist at β1 adrenergic receptors and serotonin 5-HT1A receptors.
Price Range : 1085.00 USD - 1770.00 USD

GR125743, [N-METHYL-3H]

GR125743, tritiated on the N-methyl group. GR125743 acts as an antagonist at serotonin 5-HT1B and 5-HT1D receptors.
List Price : 1810.00 USD
Receptor-expressing cell lines

ValiScreen Orexin 2 (OX2)-like (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

WGA PS Imaging Beads 500 MG

WGA-coated SPA beads, for capturing cell membranes in proximity-based scintillation assays.
List Price : 426.00 USD
Receptor-expressing cell lines

ValiScreen Muscarinic M2 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Pancreatic Polypeptide (human), [125I]

Human pancreatic polypeptide (PP), labeled with 125I. Pancreatic polypeptide acts as an agonist at Pancreatic polypeptide receptors (Neuropeptide Y receptors), a class of GPCRs involved in appetite, circadian rhythm, and anxiety.
Price Range : 1011.00 USD - 2288.00 USD
PerkinElmer

ProfilerPro Kinase Peptide Substrate 12, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 12 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 721.00 USD

Endothelin-1 (human, porcine), [125I]Tyr13

Endothelin-1 (ET-1), labeled with 125I on the tyrosine 13 residue. Endoethlin-1 is a vasoconstrictor that acts as an endogenous agonist at endothelin receptors. Endothelin receptors are a class of GPCRs that are potential drug targets for hypertension and cancer.
Price Range : 912.00 USD - 2510.00 USD

Iodoaminopotentidine, [125I]

NEX431 [125I]-Aminopotentidine has been shown to work in receptor binding and autoradiography and is an antagonist for histamine (H2) receptors.
Price Range : 855.00 USD - 1931.00 USD

"Receptor Ligand Binding" 1-50 of 570 Products and Services

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