PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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Radionuclide
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Radioisotope
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"Receptor Ligand Binding" 1-50 of 545 Products and Services

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UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.
Diclofenac sodium- Phenylacetic acid C14

Caffeine, [1-Methyl-14C]-, 50µCi (1.85MBq)

Caffeine, radiolabeled with C-14 at the 1-methyl position. Caffeine acts as a non-selective antagonist at adenosine receptors.
List Price : 816.00 USD
PerkinElmer

SPA Imaging Select-a-Bead Kit, 6 X 500 MG

SPA bead selection kit containing beads for receptor binding studies (contains 500 mg of WGA PS, WGA YOx, WGA PEI type A, WGA PEI type B, PEI PS and poly-L-lysine beads)
List Price : 426.00 USD
PerkinElmer

Membrane Target Systems: Histamine H2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Adenosine 5 Triphosphate 250 µCi

Dihydroxyphenylethylamine, 3,4-[7-3H]

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the 7 position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors. This product has a scheduled lot release for the second Monday in April and October.
Price Range : 801.00 USD - 2247.00 USD
PerkinElmer

HIS-Tag Beads YOX 500 MG

SPA beads for capturing His-tagged proteins and peptides.
List Price : 2266.00 USD
Alpha Bungarotoxin

Thyroxine, ([125I]-T4), 5700 µCi/µg

Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 902.00 USD - 2649.00 USD
Alpha Bungarotoxin

Insulin-like Growth Factor-I (human, recombinant), 125I

Insulin-like growth factor 1 (IGF-1), labeled with 125I. IGF-1 acts as an agonist at the IGF-1 receptor, a receptor tyrosine kinase, that plays a role in growth, cancer, and aging. IGF-1 also binds the insulin receptor (IR), another receptor tyrosine kinase involved in glucose homeostasis, diabetes, and cancer.
Price Range : 675.00 USD - 1656.00 USD
PerkinElmer

Membrane Target Systems: Chemotactic Peptide C3a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

DELFIA Eu-Labeling kit (Eu-N1-ITC chelate), 0.2mg

DELFIA® Europium labeling kit for labeling your own biomolecules for use in DELFIA time-resolved fluorescence assays. The ITC chelate reacts with free amine groups in the target biomolecule.
List Price : 541.00 USD
Adenosine 5 Triphosphate 250 µCi

4-DAMP, [N-Methyl-3H]-, 250µCi (9.25MBq)

4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) tritiated at the N-methyl position. 4-DAMP is a selective muscarinic acetylcholinenergic receptor M3 antagonist.
List Price : 2582.00 USD
Receptor-expressing cell lines

cAMPZen FroZen cells, Prostanoid EP2, Human Recombinant, HEK293

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 582.00 USD
Receptor-expressing cell lines

Neuropeptide FF NPFF1 ValiScreen Cell Line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

INSULIN (porcine), [125I], 10µCi (370kBq), Specific Activity:80-120µCi (2.96-4.44MBq)/µg

Insulin (porcine), labeled with 125I. Insulin is a peptide hormone that binds to insulin receptors to increase cellular uptake of glucose, increase DNA replication and protein synthesis, and modify enzymatic activity. This product is radioiodinated with 125I using a modification of the Hunter and Greenwood method and purified by ion-exchange column chromatography. This method predominantly labels tyrosine residues.
List Price : 833.00 USD
Alpha Bungarotoxin

α-Bungarotoxin, [125I]-Tyr54

α-bungarotoxin, labeled with 125I on tyrosine residue 54. α-bungarotoxin is a snake venom neurotoxin that acts as an antagonist at nicotinic acetylcholine receptors (nAChRs). This product as offered at two specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available). This indicates that virtually every molecule of ligand provided in the stock vial is radiolabeled.
Price Range : 566.00 USD - 2527.00 USD
Adenosine 5 Triphosphate 250 µCi

Substance-P (9-Sar, 11-Met(O2)), [2-Prolyl-3,4-3H]-, 50µCi (1.85MBq)

Substance-P, tritiated on the 2-prolyl group. Substance-P acts as an antagonist at neurokinin-1 receptors (NK1Rs).
List Price : 2510.00 USD
PerkinElmer

Membrane Target Systems: GABA B1b (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human GABA B1b receptor, 400 units.
List Price : 936.00 USD
Adenosine 5 Triphosphate 250 µCi

Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), DL-α-[5-Methyl-3H]

DL-α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), tritiated at the 5-methyl position. AMPA acts as an agonist at the AMPA receptor.
Price Range : 567.00 USD - 4183.00 USD
PerkinElmer

Membrane Target Systems: Adenosine A3 (rat) membrane preparation

Cell membranes prepared from cells stably-transfected with rat Adenosine A3 receptor, in HEK-293 cells.
List Price : 936.00 USD
Receptor-expressing cell lines

ValiScreen Adrenergic alpha 2A (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

PK 11195, [N-Methyl-3H]

PK-11195, tritiated on the N-methyl group. PK-11195 binds selectively to the peripheral benzodiazepine receptor (PBR).
Price Range : 606.00 USD - 4478.00 USD

WIN 35428, [N-Methyl-3H]

WIN 35428 [(–)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane], tritiated on the N-methyl group. WIN 35428 acts as an antagonist at dopamine transporters (DATs).
Price Range : 705.00 USD - 5100.00 USD
PerkinElmer

Uncoated PS Imaging Beads, 2G

Uncoated PS SPA beads have been shown to interact with primary phosphate groups in nucleotides (e.g. ATP) and oligonucleotides, DNA, and RNA. Membrane preparations can also be coupled to the beads.
List Price : 509.00 USD
Adenosine 5 Triphosphate 250 µCi

8-Hydroxy-DPAT, [Propyl-2,3-ring-1,2,3-3H]-

8-OH-DPAT radioligand tritiated at the 1,2,3 position on the propyl-2,3-ring. 8-OH-DPAT is a serotonin receptor agonist specific for the 5-HT1A and 5-HT7 receptors.
Price Range : 1200.00 USD - 3045.00 USD

Human IgG-conjugated AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to human IgG (whole). These beads are intended for use in homogenous Alpha assays to capture Fc receptors.
Price Range : 773.00 USD - 23500.00 USD
PerkinElmer

Anti-rabbit PVT 500 MG

Anti-rabbit-coated SPA beads, for capturing rabbit IgG antibodies in proximity-based radiometric scintillation assays.
List Price : 831.00 USD
Alpha Bungarotoxin

Triiodothyronine, ([125I]-T3), Specific Activity: 3300 µCi/µg

Triiodothyronine (T3) labeled with 125I. Triiodothyronine is a thyroid hormone that affects growth and development, body temperature, and heart rate. T3 detection by radioimmunoassay is a common test of thyroid gland function. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 744.00 USD - 2513.00 USD
Alpha Bungarotoxin

Triiodothyronine, ([125I]-T3), Specific Activity: 1080-1320 µCi/µg

Triiodothyronine (T3) labeled with 125I. Triiodothyronine is a thyroid hormone that affects growth and development, body temperature, and heart rate. T3 detection by radioimmunoassay is a common test of thyroid gland function. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 787.00 USD - 2272.00 USD
Alpha Bungarotoxin

Apamin [125I]His18-NH2

Apamin, labeled with 125I on histidine residue 18. Apamin is a neurotoxin that acts as an antagonist at calcium-activated potassium channels (SK channels).
Price Range : 910.00 USD - 1514.00 USD
PerkinElmer

Anti-mouse YSI 500 MG

Anti-mouse-coated SPA beads, for capturing mouse IgG antibodies in proximity-based radiometric scintillation assays.
List Price : 1028.00 USD
Alpha Bungarotoxin

Adenosine 3',5'-cyclic Phosphoric Acid, 2`-O-succinyl [125I]-Iodotyrosine Methyl Ester

cAMP, labeled with 125I on the tyrosine methyl ester group. I-125 labeled cAMP can be used as a tracer for radioimmunoassays to detect levels of endogenous cAMP in a sample or for GPCR functional assays.
Price Range : 379.00 USD - 4624.00 USD
Receptor-expressing cell lines

ValiScreen Serotonin 5HT-5A (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

(+)-Pentazocine, [Ring-1,3-3H]

(+)-Pentazocine radioligand tritiated at the 1,3 position on the ring. Pentazocine is a synthetic opioid shown to bind sigma 1 receptor.
Price Range : 621.00 USD - 4846.00 USD
Receptor-expressing cell lines

ValiScreen Prostanoid DP (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: GABA B1a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human GABA B1a receptor, 400 units.
List Price : 936.00 USD
PerkinElmer

PDE Substrate iFL-cGMP, for LabChip EZ Reader

Fluorescently-labelled cGMP for Phosphodiesterase Assays (Enyzme inhibiton, target discovery, lead optimization)
List Price : 721.00 USD
Adenosine 5 Triphosphate 250 µCi

5-Hydroxytryptamine Creatinine Sulfate, [1,2-3H(N)]

5-Hydroxytryptamine Creatinine Sulfate (Serotonin, 5-HT), tritiated at the 1,2 position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.
Price Range : 746.00 USD - 2014.00 USD
PerkinElmer

Membrane Target Systems: Cannabinoid CB2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Cannabinoid CB2 receptor, in HEK-293 cells.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Histamine H2 (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human Histamine H2 receptor, 400 units.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Chemokine CXCR2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Cannabinoid CB2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

UniFilter-96 GF/B, White 96-well Barex Microplate with GF/B filter of 1 µm poresize

GF/B glassfibre filter-bottom 96-well microplate, for receptor binding assays using a vacuum manifold.
List Price : 649.00 USD
Adenosine 5 Triphosphate 250 µCi

Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) (DPDPE)

2-D-Penicillamine, 5-D-Penicillamine (DPDPE), tritiated on the tyrosyl group. Cyclic peptide, sequence: Tyr-D-Pen-Gly-Phe-D-Pen-OH. DPDPE is a synthetic enkephalin opioid peptide that acts as an agonist at delta opiate receptors (δ-opioid receptor, DOR). This product has a scheduled lot release for the second Monday in February and August.
Price Range : 971.00 USD - 4717.00 USD
Adenosine 5 Triphosphate 250 µCi

Neurotensin, [3,11-Tyrosyl-3,5-3H(N)]

Neurotensin radioligand tritiated at the 3,5 position of the tyrosine residues. Neurotensin is a neuropeptide that acts as an agonist on the neurotensin receptor family.
Price Range : 664.00 USD - 3490.00 USD

"Receptor Ligand Binding" 1-50 of 545 Products and Services

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