Radiometric detection is considered the gold standard for many applications, from drug discovery and development to plant sciences. The technique achieves sub-femtogram sensitivity levels, and quantitates the binding and activity of radiolabeled compounds with high specificity and sensitivity. As the leading supplier of research radiochemicals, we offer a broad portfolio of products for any radiochemistry need.
Our radiochemical analysis products include:
Radionuclides such as 124I, 14C, 89Zr, 90Y, 125I, 131I, 22Na, 32P, 35S, 3H, 45Ca, 51Cr, 54Mn, 55Fe, 59Fe, 85Sr
EasyTag™ protein labeling mixes
EasyTide radiolabeled nucleotides
NEN radiolabeled compounds
SPA Enzymatic assays and imaging beads
Our radiolabeled compounds are useful in a wide range of applications:
Research in cancer, CNS and neurologic disease, cardiovascular and metabolic disease, inflammation, and other disorders
Kinetic and mechanistic studies
Radiometric cAMP assays
Detection of binding to over 80 different receptor types
Our radiometric reagents are not reliant on the use of antibodies for detection and read-out – just one of the reasons they are so widely used.
Acetylcholine (Ach) radioligand tritiated on the acetyl group. Acetylcholine is a neurotransmitter and the endogeous ligand that binds to and activates muscarinic and nicotinic acetylcholine receptors.
Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Bolton-Hunter reagent, monoiodinated. This product is used to iodinate proteins that do not contain tyrosine residues. Bolton-Hunter reagent is the N-hydroxysuccinimide ester of iodinated p-hydroxyphenylpropionic acid. The active ester acylates terminal amino groups with the iodinated p-hydxyphenylpropionic residue, effectively introducing radioactive iodine into proteins and peptides. A non-oxidative technique, it is less harsh to proteins than alternative labeling methods. An anhydrous benzene A charcoal trap is provided with each vial.