Protein-protein Interaction

OF

Accurately measure the function of proteins and gain new insights into protein-protein interaction (PPI) to modulate cellular processes. Inhibition and stabilization of these interactions using small molecules provides a mechanism that can be targeted for drug discovery.

We offer the technology to measure protein-protein interaction such as:

  • Transient and stable interactions
  • Low-to-high affinity interactions (pM to mM affinity)
  • Full-length protein-protein binding
  • Peptide-protein
  • Receptor dimerization
  • Protein-small molecule
  • Protein complex interactions

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Product Type
  • Accessories (8)
  • Instruments (6)
  • Reagents (223)
Antibody conjugates
  • Anti-6X His (12)
  • Anti-bovine IgA (3)
  • Anti-c-Myc (5)
  • Anti-C-tag (3)
  • Anti-DIG (4)
  • Anti-DNP (2)
  • Anti-FITC (9)
  • Anti-FLAG (16)
  • Anti-GFP (3)
  • Anti-goat IgG (3)
  • Anti-GST (4)
  • Anti-HA (6)
  • Anti-HRP (6)
  • Anti-human IgG (7)
  • Anti-MBP (1)
  • Anti-mouse IgG (7)
  • Anti-rabbit IgG (6)
  • Anti-rat IgG (6)
  • Anti-V5 (2)
  • Glutathione (7)
  • Nickel chelate (1)
  • Protein A (9)
  • Protein G (3)
  • Protein L (3)
  • Strep-Tactin (3)
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  • Streptavidin/Anti-c-Myc (1)
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  • Streptavidin/Anti-FITC (3)
  • Streptavidin/Anti-FLAG (3)
  • Streptavidin/Anti-GST (1)
  • Streptavidin/Anti-HA (3)
  • Streptavidin/Anti-mouse IgG (1)
  • Streptavidin/Anti-rabbit IgG (1)
  • Streptavidin/Nickel chelate (3)
  • Streptavidin/Protein A (1)
  • Unconjugated (6)
Application
  • Antibody binding (3)
  • Enzymatic (5)
  • Isotyping (3)
  • Multiplexing (6)
  • Protein Analysis & Detection (85)
  • Protein-nucleic acid interactions (10)
  • Protein-protein interactions (164)
Assay Points
  • 100 (5)
  • 10000 (10)
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  • 5000 (19)
  • 50000 (10)
Assay Target
  • COX-1 (3)
  • EGF (3)
  • EGFR (4)
  • FCGR3A (4)
  • Histone H4 (28)
  • MMP-7 (3)
  • PD-1 (3)
  • PD-L1 (4)
Assay Target Class
  • Fc-receptor (4)
  • Histone (28)
  • Protein (14)
Automation Compatible
  • Yes (224)
Detection Method
  • Absorbance (5)
  • Alpha (152)
  • DELFIA TRF (7)
  • Fluorescence (5)
  • Fluorescence Polarization (3)
  • Image-based Cytometry (1)
  • Label-free (2)
  • Luminescence (5)
  • Time-Resolved Fluorescence (TRF) (28)
  • TR-FRET (16)
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  • In vitro (172)
Fluorophore
  • Eu-N1 (5)
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  • Eu-W8044 (1)
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  • Tb-N1 (1)
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Format
  • Microplates (191)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)
Molecular modification
  • Acetylation (28)
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  • Alpha (12)
  • AlphaLISA (106)
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Target Species
  • Human (18)
Therapeutic Area
  • Biologics/Bioprocess (4)
  • Cancer (14)
  • Epigenetics (28)
Volume
  • 0-50 (77)
  • 201-250 (32)
  • 451-500 (10)
  • Over 500 (10)

"Protein-protein Interaction" 1-50 of 237 Products and Services

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EnSpire Multimode Plate Reader

EnSpire® Multimode Plate Reader is designed to meet the demands of multi-user research environments, providing high performance technology and flexibility for a range of applications without compromising sensitivity. Combine this with our expertise and portfolio of reagents, PerkinElmer offers an unrivaled solution to your application needs.

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.

VictorX_ImageA_320px

VICTOR Multilabel Plate Reader

The next generation VICTOR X Multilabel Plate Reader platform delivers flexibility, speed and performance to research labs of all sizes.

EnSpire Alpha Plate Reader

The EnSpire Alpha Plate Reader provides proven Alpha technology to your lab at an affordable price and from the Alpha detection leader.

EnSight Multimode Plate Reader

The EnSight Multimode Plate Reader is the first benchtop system to offer well-imaging alongside label-free and labeled detection technologies.

EnVision_Alone_Left_Angle

EnVision Multilabel Reader

The EnVision Multilabel Plate Reader provides the highest speed, ultra-high throughput, and maximum sensitivity across  all detection technologies, so that your high throughput screening applications won’t be held back by unreliable results or equipment that can’t keep up to the demands of escalating workloads and new assays.

Protein A AlphaPlex™ 545 Acceptor Beads 25 mg

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to Protein A, for use in Alpha no-wash multiplexing assays.

List Price: 22700.00 USD
AlphaLISA-antibody-coated

Anti-mouse IgG (Fc specific) AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-mouse IgG antibody. These beads can be used to capture mouse IgG antibodies. The antibody is Fc-specific, and is a goat polyclonal F(ab')2 fragment.

List Price: 5500.00 USD
AlphaPlex Samarium Acceptor Beads

Protein A AlphaPlex™ 645 (Sm) Acceptor Beads

AlphaPlex-645 (Samarium) Acceptor beads conjugated to Protein A. These beads are used to capture immunoglobulins through their heavy chain (Fc region) allowing optimal orientation and antigen detection. Protein A has higher affinity for rabbit, pig, dog and cat IgG.

List Price: 554.00 USD
AlphaLISA-antibody-coated

Anti-GST AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-GST antibody. These beads can be used to capture GST-tagged proteins and peptides in AlphaLISA no-wash assays.

List Price: 22700.00 USD
AlphaLISA-antibody-coated

Anti-bovine IgA AlphaLISA Acceptor Beads, 5 mg

AlphaLISA Acceptor beads conjugated to anti-bovine IgA antibody. These beads can be used to capture bovine IgA antibodies.

List Price: 5700.00 USD

AlphaLISA BRD4_BD1 / H4 K12Ac Binding Kit, 500 points

This kit is designed for the detection of binding activity between bromodomain-containing protein 4, Bromodomain1: BRD4 (BD1) and acetylated histone H4 peptide (H4 K12Ac) using a homogeneous AlphaLISA assay (no wash steps). The assay allows screening of BRD4 inhibitors with a highly-specific substrate.

List Price: 773.00 USD
AlphaPlex-545-antibody-bead2

Anti-HA AlphaPlex 545 (Tb) Acceptor Beads

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to anti-HA (hemaglutinin) antibody. These beads can be used to capture HA-tagged proteins and peptides.

List Price: 554.00 USD
Acceptor bead

Anti-HRP AlphaLISA Acceptor Beads, 5 mg

AlphaLISA® Acceptor beads conjugated to anti-HRP antibody. These beads can be used to capture HRP-fusion proteins for AlphaLISA no-wash assays.

List Price: 5400.00 USD

LANCE Eu-W1024 anti-FITC,10 µg

Eu-W1024 labeled anti-FITC antibodies for LANCE® TR-FRET assays. The anti-FITC antibody is a purified mouse IgG2a monoclonal antibody.

List Price: 300.00 USD

DELFIA Sm-N1 Streptavidin

Samarium-labeled streptavidin for binding biotinylated biomolecules in DELFIA® time-resolved fluorescence (TRF) assays.

List Price: 289.00 USD

LANCE Eu-W1024 Anti-6xHis

Europium-labeled anti-6X His antibody, for capturing His-tagged proteins in LANCE® TR-FRET assays.

List Price: 222.00 USD

AlphaLISA BRD4_BD2 / H4 K5,8,12Ac Binding Kit, 500 points

This kit is designed for the detection of binding activity between bromodomain-containing protein 4, Bromodomain2: BRD4 (BD2) and acetylated histone H4 peptide (H4 K5,8,12Ac) using a homogeneous AlphaLISA assay (no wash steps). The assay allows screening of BRD4 inhibitors with a highly-specific substrate.

List Price: 773.00 USD
AlphaLISA-antibody-coated

Anti-GFP AlphaLISA® Acceptor beads, 250 µg

AlphaLISA® Acceptor beads conjugated to anti-GFP antibody. The antibody is a mouse monoclonal antibody that recognizes wildtype and recombinant GFP (rGFP), and cross-reacts with eGFP. These beads can be used to capture GFP-tagged proteins for AlphaLISA no-wash assays.

List Price: 554.00 USD
Acceptor bead

Anti-HRP AlphaLISA Acceptor Beads, 25 mg

AlphaLISA® Acceptor beads conjugated to anti-HRP antibody. These beads can be used to capture HRP-fusion proteins for AlphaLISA no-wash assays.

List Price: 22100.00 USD
AlphaPlex-545-antibody-bead2

Anti-FLAG AlphaPlex-545 (Tb) Acceptor beads, 5 mg

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to anti-FLAG antibody, for use in Alpha no-wash multiplexing assays.

List Price: 5500.00 USD
AlphaLISA Bromodomain Binding Assay kits

AlphaLISA BRD4_BD2 / H4 K12Ac Binding Kit, 5,000 points

This kit is designed for the detection of binding activity between bromodomain-containing protein 4, Bromodomain2: BRD4 (BD2) and acetylated histone H4 peptide (H4 K12Ac) using a homogeneous AlphaLISA assay (no wash steps). The assay allows screening of BRD4 inhibitors with a highly-specific substrate.

List Price: 4118.00 USD
AlphaScreen-anti-tag-kit

AlphaScreen C-MYC Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-c-myc-conjugated AlphaScreen Acceptor beads. This kit contains enough reagents to run 500 wells in 384-well format, using a 25 µL reaction volume.

List Price: 170.00 USD

COX-2 (human) AlphaLISA Detection Kit, 5,000 Assay Points

The AlphaLISA® immunoassay kit for human COX-2 enables the detection and quantitation of human COX-2 in cell culture supernatants and cell extracts using a homogeneous AlphaLISA assay (no wash steps). The assay shows no cross-reactivity with human COX-1 nor with sheep COX-2.

List Price: 29500.00 USD
AlphaLISA Bromodomain Binding Assay kits

AlphaLISA BRD4_BD1 / H4 K8,16Ac Binding Kit, 5,000 points

This kit is designed for the detection of binding activity between bromodomain-containing protein 4, Bromodomain1: BRD4 (BD1) and acetylated histone H4 peptide (H4 K8,16Ac) using a homogeneous AlphaLISA assay (no wash steps). The assay allows screening of BRD4 inhibitors with a highly-specific substrate.

List Price: 4118.00 USD
AlphaLISA Binding Assay kits

EGF/EGFR AlphaLISA Binding Kit, 5,000 Assay Points

The AlphaLISA® EGF/EGFR Binding Kit is designed for the detection of binding activity between Human EGF and EGFR, using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of therapeutics which competitively inhibit the EGF/EGFR interaction.

List Price: 9200.00 USD
AlphaPlex-545-antibody-bead2

Anti-6X His AlphaPlex™ 545 Acceptor beads, 25 mg

AlphaPlex™-545 Acceptor beads conjugated to anti-6XHis antibody, for use in Alpha no-wash multiplexing assays.

List Price: 22700.00 USD
Alpha Fc receptor bind

FCGR3A/CD16a (176Val/V158) AlphaLISA Binding Kit, 5,000 Assay Points

This kit is designed for the detection of binding activity between human FCGR3A (176Val) and human IgG Fc fragment using a homogeneous AlphaLISA® assay (no wash steps). This assay can facilitate the design and development of antibody therapetics by using competitive binding.

List Price: 10000.00 USD
AlphaLISA Bromodomain Binding Assay kits

AlphaLISA BRD4_BD2 / H4 K5,8,12Ac Binding Kit, 5,000 points

This kit is designed for the detection of binding activity between bromodomain-containing protein 4, Bromodomain2: BRD4 (BD2) and acetylated histone H4 peptide (H4 K5,8,12Ac) using a homogeneous AlphaLISA assay (no wash steps). The assay allows screening of BRD4 inhibitors with a highly-specific substrate.

List Price: 4118.00 USD
streptactin-AlphaLISA

Strep-Tactin® AlphaLISA® Acceptor beads, 25 mg

AlphaLISA® Acceptor beads conjugated to Strep-Tactin®. These beads can be used to capture Strep-tag® II-tagged proteins for AlphaLISA no-wash assays.

List Price: 22100.00 USD

DELFIA® Eu-N1 Anti-HA

Europium-labeled anti-HA antibody for binding HA-tagged proteins in DELFIA® time-resolved fluorescence (TRF) assays. The anti-HA antibody is a purified IgG2b subclass of mouse monoclonal antibody. It recognizes the epitope sequence (YPYDVPDYA) derived from the human influenza hemagglutinin (HA) protein.

List Price: 592.00 USD
AlphaLISA Bromodomain Binding Assay kits

AlphaLISA BRD4_BD1 / H4 K8Ac Binding Kit, 5,000 points

This kit is designed for the detection of binding activity between bromodomain-containing protein 4, Bromodomain1: BRD4 (BD1) and acetylated histone H4 peptide (H4 K8Ac) using a homogeneous AlphaLISA assay (no wash steps). The assay allows screening of BRD4 inhibitors with a highly-specific substrate.

List Price: 4118.00 USD
AlphaLISA-antibody-coated

Anti-bovine IgA AlphaLISA Acceptor Beads, 250 ug

AlphaLISA Acceptor beads conjugated to anti-bovine IgA antibody. These beads can be used to capture bovine IgA antibodies.

List Price: 751.00 USD
Acceptor bead

Anti-HRP AlphaLISA Acceptor Beads, 250 µg

AlphaLISA® Acceptor beads conjugated to anti-HRP antibody. These beads can be used to capture HRP-fusion proteins for AlphaLISA no-wash assays.

List Price: 538.00 USD
AlphaLISA Bromodomain Binding Assay kits

AlphaLISA BRD4_BD2 / H4 K5,12Ac Binding Kit, 5,000 points

This kit is designed for the detection of binding activity between bromodomain-containing protein 4, Bromodomain2: BRD4 (BD2) and acetylated histone H4 peptide (H4 K5,12Ac) using a homogeneous AlphaLISA assay (no wash steps). The assay allows screening of BRD4 inhibitors with a highly-specific substrate.

List Price: 4118.00 USD

AlphaLISA BRD4_BD2 / H4 K5,12Ac Binding Kit, 500 points

This kit is designed for the detection of binding activity between bromodomain-containing protein 4, Bromodomain2: BRD4 (BD2) and acetylated histone H4 peptide (H4 K5,12Ac) using a homogeneous AlphaLISA assay (no wash steps). The assay allows screening of BRD4 inhibitors with a highly-specific substrate.

List Price: 773.00 USD
AlphaLISA-antibody-coated

Anti-bovine IgA AlphaLISA Acceptor Beads, 25 mg

AlphaLISA Acceptor beads conjugated to anti-bovine IgA antibody. These beads can be used to capture bovine IgA antibodies.

List Price: 25400.00 USD
AlphaLISA_glutathione

Glutathione AlphaLISA Acceptor Beads 250 µg

AlphaLISA® Acceptor beads conjugated to glutathione. These beads can be used to capture GST-tagged proteins and peptides.

List Price: 554.00 USD
AlphaLISA-antibody-coated

Anti-Maltose-Binding Protein (MBP) AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to anti-MBP (maltose-binding protein) antibody. The antibody is a rat monoclonal antibody, clone MBP 7G4. These beads can be used to capture MBP-tagged proteins for AlphaLISA no-wash assays.

List Price: 554.00 USD
AlphaPlex Samarium Acceptor Beads

Streptavidin AlphaPlex™ 645 (Sm) Acceptor Beads

The Streptavidin coated AlphaPlex™ 645 (Samarium) Acceptor beads are used to capture a wide variety of biotinylated reagents, ranging from small nucleotides to very large proteins. To avoid steric hindrance, it is recommended to use biotin derivatives including an aliphatic spacer composed of at least six carbons.

List Price: 5500.00 USD

Anti-DNP AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-DNP antibody. These beads can be used to capture DNP-labeled proteins, peptides, and small molecules.

List Price: 750.00 USD
AlphaLISA-antibody-coated

Anti-rabbit IgG (Fc specific) AlphaLISA Acceptor Beads 5 mg

AlphaLISA® Acceptor beads conjugated to anti-rabbit IgG antibody. These beads can be used to capture rabbit IgG antibodies. The antibody is Fc-specific, and is a goat polyclonal F(ab')2 fragment.

List Price: 5500.00 USD

AlphaScreen Mouse IgG Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-mouse IgG conjugated AlphaScreen Acceptor beads.

List Price: 170.00 USD
Protein

COX-2 (human), frozen (AlphaLISA)

Human COX-2 standard, frozen, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Human COX-2 Detection Kit, but can be ordered separately.

List Price: 2621.00 USD
AlphaScreen-anti-tag-kit

AlphaScreen HA (Hemagglutinin) Detection Kit, 500 assay points

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-HA (hemagglutinin) conjugated AlphaScreen Acceptor beads. This kit contains enough reagents to run 500 wells in 384-well format, using a 25 µL reaction volume.

List Price: 170.00 USD
Unconjugated-samarium-beads

Unconjugated AlphaPlex™ 645 Acceptor Beads, 1 mg

Unconjugated AlphaPlex 645 (Samarium) Acceptor beads bear reactive aldehyde groups at their surface, allowing you to conjugate a wide variety of reagents using a simple reductive amination protocol.

List Price: 1265.00 USD

Anti-C-tag AlphaLISA Acceptor Beads, 5mg

AlphaLISA Acceptor beads conjugated to anti-C-tag antibody. These beads can be used to capture C-tag proteins, and can be used in conjunction with Alpha Donor beads to create AlphaLISA no-wash assays.

List Price: 5600.00 USD
AlphaLISA assay principle

MMP-7 (human) AlphaLISA Detection Kit, 100 Assay Points

The AlphaLISA® immunoassay kit for human MMP7 enables the detection and quantitation of human pro- and active MMP-7 (hMMP-7) in serum, buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).

List Price: 420.00 USD
AlphaPlex-545-antibody-bead2

Anti-human IgG AlphaPlex 545 Acceptor Beads, 250 µg

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to anti-human IgG antibody, for use in Alpha no-wash multiplexing assays.

List Price: 554.00 USD

LANCE Eu-W1024 anti-FITC, 1 mg

Eu-W1024 labeled anti-FITC antibodies for LANCE® TR-FRET assays. The anti-FITC antibody is a purified mouse IgG2a monoclonal antibody.

List Price: 8400.00 USD

"Protein-protein Interaction" 1-50 of 237 Products and Services

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