PerkinElmer

Metabolic Disease

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Metabolic diseases like diabetes are increasingly widespread, and research for this class of diseases relies on discovering and quantifying biomarkers to elucidate underlying mechanisms and uncover novel drug targets. Our portfolio of metabolic assays are well suited for metabolic disease research in vitro, in vivo, and in situ, and offer novel tools for your research workflow from start to finish.

Metabolic diseases are systemic and manifest with a variety of biological changes, from autophagy dysfunction to altered blood coagulation. For easy detection of a wide range of metabolic biomarkers, we offer fast and pre-validated metabolic assay reagents, kits, and imaging systems. For targeted binding studies, we also provide target-specific radiolabeled reagents.

Our products for metabolic disease research include:

  • LANCE® TR-FRET technology
  • AlphaLISA® immunoassay kits
  • Alpha reagents for AlphaLISA
  • DELFIA® TRF technology
  • Cellular, tissue, and in vivo imaging systems
  • Target-specific radiolabeled ligands, carbohydrates, lipids, and steroids

The range of tools offered allows for the detection and quantitation of many key biomolecules in metabolic disease research. Gain precise insight on disease biomarkers like c-reactive protein, fibrinogen, IGF, FGF, insulin and glucagon, leptin and ghrelin, adiponectin, and factor VIII.

Business Insights (2)
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  • Application Note

    MicroCT Investigation of Bone Erosion and Deformation in an Osteoarthritic Rat Model

    Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of bones within the joints gradually deteriorates, causing synovitis and joint deformation.

    The goal of OA research is to identify new therapeutic strategies that could prevent, reduce, halt progression, or repair the existing damage to the joint. Non-invasive in vivo imaging such as microCT is the standard modality for bone research due to its ability to obtain high-resolution images at an x-ray dose low enough as not to harm the animal. This makes microCT ideal for monitoring disease progression and response to treatments in the same animal over time. However, microCT data visualization and analysis can be cumbersome and time consuming. In this application note, we compared standard microCT software and advanced bone software to investigate bone erosion in an OA rat model.

  • Application Note

    Contrast-enhanced Imaging of Vasculature and Soft Tissues Using the Quantum GX MicroCT System

    X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood vessels and internal organs share similar x-ray attenuation characteristics and are not distinguishable under typical CT settings. In order to introduce density that would improve soft tissue contrast, several contrast agents have been developed for use in clinical and preclinical settings. This application note outlines the use of iodine and nanoparticle-based contrast agents for imaging soft tissues and vasculature in various organs using the Quantum GX to gain further insights into disease and therapeutic response.

Products & Services (146)
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Product Type
  • Instruments (1)
  • Reagents (141)
  • Software and Informatics (4)
Assay Target
  • Adiponectin (3)
  • Albumin (5)
  • ApoA1 (4)
  • ApoB (2)
  • ApoC3 (2)
  • ApoE (2)
  • AST (1)
  • BMP-9 (1)
  • C-peptide (2)
  • CCL2 (1)
  • Corticosterone (2)
  • Cortisol (3)
  • CYCS (1)
  • Factor VIII (1)
  • FSH (3)
  • Ghrelin (4)
  • GLP-1 (2)
  • Glucagon (3)
  • Growth Hormone (1)
  • hCG (3)
  • HO-1 (1)
  • HO-2 (1)
  • IGF1 (5)
  • IGF2 (1)
  • Insulin (4)
  • KIM-1 (1)
  • LDH (1)
  • Leptin (5)
  • MANF (2)
  • MBNL1 (1)
  • NNMT (1)
  • Osteoprotegerin (1)
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  • Human (77)
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  • Protein Analysis & Detection (83)
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  • Angiogenesis (1)
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  • Metabolic (63)
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  • AlphaLISA (54)
  • AlphaPlex (2)
  • LANCE Ultra (28)
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  • NEN Radiochemicals (54)
  • Quantum (1)
Detection Method
  • Alpha (56)
  • Radiometric (55)
  • Time-Resolved Fluorescence (TRF) (25)
  • TR-FRET (25)
Receptor Type
  • Ghrelin (1)
Assay Validated
  • Binding (1)
Radioisotope
  • C-14 (27)
  • H-3 (28)
Radionuclide
  • 14C (27)
  • 3H (28)
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  • Generally Labeled (2)
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  • Aqueous (10)
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  • 100 (29)
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  • Yes (85)
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  • 0.02 mCi/mL (1)
  • 0.05 mCi/mL (1)
  • 0.1 mCi/mL (11)
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  • 1 mCi/mL (17)
Experimental Type
  • In vitro (70)
Format
  • Microplates (67)
Host Cell
  • CHO-K1 (1)
Imaging Modality
  • microCT Imaging (1)
Length
  • 901-1000 (1)
Volume
  • 0-50 (15)
  • 201-250 (4)

1-12 of 146 Products & Services

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  • Quantum GX2 microCT imaging system

    Quantum GX2 microCT Imaging System

    Image beyond bone – into oncology, cardiovascular and pulmonary diseases, and much more, with the Quantum GX2 microCT imaging system. With the Quantum GX2, flexibility is key. Combining the ability to perform high speed, low dose scans, ideal for longitudinal studies, across multiple species (mice, rats, rabbits) with high resolution ex vivo scanning, the Quantum GX2 microCT imaging system offers the flexibility and performance you need to not just image, but further understand your disease models.
  • AlphaLISA immunoassay kits

    Testosterone AlphaLISA Detection Kit

    The AlphaLISA® Testosterone Research Kit is designed for detection and quantitation of testosterone in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 672.00 USD - 10500.00 USD
  • AlphaLISA immunoassay kits

    Progesterone AlphaLISA Detection Kit

    The AlphaLISA® Progesterone Detection Kit is designed for detection and quantitation of progesterone in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 724.00 USD - 10500.00 USD
  • AlphaLISA immunoassay kits

    hCG (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human chorionic gonadotropin (hCG) enables the quantitative determination of hCG in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 541.00 USD - 16200.00 USD
  • ApoB (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human ApoB enables the quantitative determination of human apolipoprotein B in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 625.00 USD - 18800.00 USD
  • NNMT (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human Nicotinamide N-Methyltransferase (NNMT) enables the quantitative determination of human NNMT in buffered solution, cell culture media, and serum using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 759.00 USD - 14600.00 USD
  • Adenosine 5 Triphosphate 250 µCi

    Glucosamine Hydrochloride, D-[6-3H(N)]-, Aqueous solution, Specific Activity: 20-45Ci (740GBq-1.66TBq)/mmol, 250µCi (9.25MBq)

    250 µCi quantities of tritiated D-glucosamine hydrochloride are available for your research.
    List Price : 542.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Methyl α-D-glucopyranoside, [Glucose-14C(U)]-, 50µCi (1.85MBq)

    50 µCi quantities of [Glucose-14C(U)]-Methyl α-D-glucopyranoside are available for your research.
    List Price : 1195.00 USD
  • AlphaLisa Analyte 2

    IGF-1 (rat), lyophilized (AlphaLISA)

    Rat IGF-1 standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA Rat IGF-1 Detection Kit, but can also be ordered separately.
    List Price : 308.00 USD
  • C-Peptide (mouse/rat) AlphaLISA Detection Kit

    The AlphaLISA® Mouse/Rat Connecting Peptide (C-Peptide) Detection Kit is designed for detection and quantitation of mouse or rat C-Peptide in buffered solution in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 3036.00 USD - 23700.00 USD
  • AlphaLISA immunoassay kits

    Heme oxygenase 1 AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human heme oxygenase 1 (HO-1) enables the quantitative determination of human HO-1 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 451.00 USD - 9900.00 USD
  • AlphaLISA immunoassay kits

    AST (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human AST enables the quantitative determination of human aspartate transaminase (AST) in buffered solution, cell culture media, and serum using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 759.00 USD - 14600.00 USD
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