PerkinElmer

Ligands

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Eliminate the need for antibodies and reduce assay time with direct detection using our radiolabeled ligands, which provide for sensitive and quantitative measurement of binding.

  • High specific activity — The majority of our 125I-labeled ligands are offered at maximum specific activity. This means virtually every molecule of ligand provided in the stock vial is radiolabeled. For tritiated ligands (3H ligands), pick a ligand with specific activity above 20 Ci/mmol – all of our tritiated ligands meets or exceeds these requirements.
  • High purity — We offer highly-pure radioligands for the highest specific signal with low background in binding assays.
  • High selectivity — Our broad portfolio of agonists and antagonists offers many options for choosing the most selective compound for your receptor.
  • Validated for receptor binding — all of our radioligand products are tested for receptor binding during development. Additionally, many of our radioligands are used to QC our GPCR and receptor cell lines and cell membrane products.

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Application
  • Drug Discovery & Development (118)
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Concentration
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  • 1.0 - 10 mCi/mL (61)
  • 1.0 - 10 µCi/mL (3)
  • 1.0 mCi/mL (1)
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Detection Method
  • Radiometric (121)
Label Position
  • Generally Labeled (6)
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  • Uniformly Labeled (1)
Product Brand Name
  • NEN Radiochemicals (122)
Radionuclide
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  • 33P (1)
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  • 3H (1)
  • 3H (116)
Radioisotope
  • C-14 (6)
  • H-3 (117)
  • P-33 (1)
  • S-35 (1)
Receptor Type
  • 5-Hydroxytryptamine (11)
  • Acetylcholine (1)
  • Acetylcholine (Muscarinic) (6)
  • Adenosine (4)
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Volume
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"Ligands" 1-50 of 125 Products and Services

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Butyl Bicyclophosphorothionate, Tertiary-[35S]

Tertiary-Butylbicyclophosphorothionate (TBPS), radiolabeled with S-35. TBPS is a GABAA receptor antagonist.
Price Range : 2003.00 USD - 3538.00 USD

Oxotremorine-M Acetate, [Methyl-3H]-,>97%, 250µCi (9.25MBq)

Oxotremorine-M acetate, tritiated on the methyl group. Oxotremorine-M acts as a selective agonist at muscarinic acetylcholine receptors.
List Price : 2288.00 USD

Clonidine Hydrochloride, [Benzene Ring-3H]-, 250µCi (9.25MBq)

Clonidine hydrochloride, tritiated on the benzene ring. Clonidine is a drug used to treat high blood pressure, ADHD, anxiety disorders, and drug withdrawal and acts as an agonist at α2 adrenergic and imidazoline receptors.
List Price : 1306.00 USD

Pirenzepine, [N-Methyl-3H]

Pirenzepine, tritiated on the N-methyl group. Pirenzepine acts as a selective antagonist of the muscarinic M1 acetylcholine receptor.
Price Range : 1940.00 USD - 4909.00 USD

AH5183, L-[PIPERIDINYL-3,4-3H]-(VESAMICOL), 250 µCi

AH5183 (vesamicol) radioligand tritiated at the piperidinyl-3,4 position. AH5183 is an acetylcholine transport blocker.
List Price : 960.00 USD

Glibenclamide, Glyburide, [Cyclohexyl-2,3-3H(N)]-, 250µCi (9.25MBq)

Glibenclamide (glyburide) tritiated at the cyclohexyl-2,3 position. Glibenclamide is an antidiabetic drug that binds and inhibits the ATP-sensitive potassium channel.
List Price : 2445.00 USD

Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), DL-α-[5-Methyl-3H]

DL-α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), tritiated at the 5-methyl position. AMPA acts as an agonist at the AMPA receptor.
Price Range : 567.00 USD - 4183.00 USD

Rauwolscine, [Methyl-3H]-, 250µCi (9.25MBq)

Rauwolscine, tritiated on the methyl group. Rauwolscine acts as an antagonist at α2-adrenergic receptors.
List Price : 1873.00 USD

DAMGO, [Tyrosyl-3,5-3H(N)]

DAMGO, tritiated at the tyrosyl 3,5 poisition. DAMGO is a synthetic opioid analog with high specificity for the μ-opioid receptor.
Price Range : 1720.00 USD - 4448.00 USD

RO 15-4513, [7,9-3H]-, 250µCi (9.25MBq)

Ro15-4513, tritiated at the 7,9 position. Ro15-4513 is a partial inverse agonist at GABAA receptors.
List Price : 2405.00 USD

AF-DX 384, [2,3-Dipropylamino-3H]-, 250µCi (9.25MBq)

AFDX-384 (BIBN-161) radioligand tritiated at the 2,3-dipropylamino position. AFDX-384 acts as a selective antagonist of muscarinic acetylcholine receptors, with selectivity for the M2 and M4 subtypes.
List Price : 1945.00 USD

R(+)7-HYDROXY DPAT, [3H], 250 µCi

Tritiated R(+)7-Hydroxy DPAT. 7-OH-DPAT acts as a selective agonist at the dopamine D3 receptor. It also has low affinity for serotonin receptors.
List Price : 3292.00 USD

Nicotine, L-(-)-[N-Methyl-3H]

Nicotine radioligand tritiated on the methyl residue. Nicotine acts as an agonist at most nicotinic acetylcholine receptors; however it acts as an antagonist at two nicotinic receptor subunits (nAChRα9 and (nAChRα10). 
Price Range : 499.00 USD - 3850.00 USD

Norepinephrine, Levo-[7-3H]

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).
Price Range : 1195.00 USD - 9100.00 USD

Verapamil Hydrochloride, [N-Methyl-3H]

Verapamil hydrochloride, tritiated on the N-methyl group. Verapamil acts as a calcium channel blocker (CCB).
Price Range : 680.00 USD - 2571.00 USD

Ro 15-1788, [N-Methyl-3H]

Ro 15-1788 (flumazenil), tritiated on the N-methyl group. Ro 15-1788 acts as a selective benzodiazepine antagonist.
Price Range : 648.00 USD - 4858.00 USD

MK-801, (+)-[3-3H]-

(+)-MK-801 radioligand tritriated at the 3 position. MK-801 acts as a non-competitive antagonist at the glutamate receptor, N-Methyl-D-aspartate (NMDA).
Price Range : 648.00 USD - 4555.00 USD

ROLIPRAM, [METHYL-3H]

Rolipram, tritiated on the methyl group. Rolipram is a selective phosphodiesterase-4 inhibitor.
List Price : 3463.00 USD

Methylhistamine Dihydrochloride, N-α-[methyl-3H]-, 250µCi (9.25MBq)

(R)-α-methylhistamine dihydrochloride, tritiated on the methyl group. α-Methylhistamine is a histamine agonist selective for the histamine H3 receptor.
List Price : 1094.00 USD

PK 11195, [N-Methyl-3H]

PK-11195, tritiated on the N-methyl group. PK-11195 binds selectively to the peripheral benzodiazepine receptor (PBR).
Price Range : 606.00 USD - 4478.00 USD

CCK-8(SULPHATED), [3H]PROPIONY, 50 µCi

CCK-8, tritiated at the propionyl position. Sulphated CCK8 is a peptide hormone that can bind both cholecystokinin B and cholecystokinin A receptors.
List Price : 1696.00 USD

SCH 23390, [N-Methyl-3H]

SCH-23390 (halobenzazepine), tritiated on the N-methyl group. SCH-23390 acts as an antagonist at the dopamine D1 receptor.
Price Range : 520.00 USD - 2845.00 USD

3-INDOLYLACETIC ACID, [5-3H(N)]-

3-Indolyacetic acid tritiated at the 5 position. Indole-3-acetic acid (IAA, 3-IAA) is the most common, naturally occurring, plant hormone of the auxin class.
List Price : 1463.00 USD

Oxytocin, [Tyrosyl-3,5-3H]-, 50µCi (1.85MBq)

Oxytocin, tritiated on the tyrosyl group. Oxytocin is a neurotransmitter that binds and activates oxytocin receptors.
List Price : 1287.00 USD

Nitrendipine, [5-Methyl-3H]-, 25µCi (925kBq)

Nitrendipine, tritiated on the 5-methyl group. Nitrendipine is a dihydropyridine calcium channel blocker.
List Price : 894.00 USD

Kainic acid, [Isopropenyl-3H]

Kainic acid, tritiated on the isoproprenyl group. Kainic acid acts as an agonist at kainate glutamate receptors.
Price Range : 568.00 USD - 5300.00 USD

MESULERGINE, [N-METHYL-3H]-, 250 µCi

Mesulergine, tritiated on the N-methyl group. Mesulergine acts as an antagonist at serotonin 5-HT2A and 5-HT2C receptors, and as a partial agonist at dopamine receptors.
List Price : 1776.00 USD

Ifenprodil, [Phenyl-3H]-, 250µCi (9.25MBq)

Ifenprodil, tritiated on the phenyl group. Ifenprodil acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor.
List Price : 1990.00 USD

Ketanserin Hydrochloride (R41 468), [Ethylene-3H]

Ketanserin hydrochloride (Sufrexal; R41468), tritiated on the ethylene group. Ketanserin is a high-affinity non-selective antagonist of 5-HT2 receptors.
Price Range : 614.00 USD - 5500.00 USD

CP 55940, [Side Chain-2,3,4-3H(N)]

CP 55,940, tritiated on the side chain-2,3-4 position. CP 55,940 is a synthetic cannabinoid that acts as a full agonist at both cannabinoid CB1 and CB2 receptors, and can also upregulate serotonin 5-HT2A receptors.
Price Range : 669.00 USD - 4915.00 USD

5-CT, [3H]

5-carboxyamidotryptamine (5-CT) labeled with tritium. 5-CT is a tryptamine derivative closely related to the neurotransmitter serotonin. 5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 serotonin receptors. It also binds the 5-HT2, 5-HT3, 5-HT6 serotonin receptors with lower affinity.
List Price : 1261.00 USD

NALOXONE, [N-ALLYL-2,3-3H]-

Naloxone radioligand tritiated at the 2,3 position. Naloxone acts as a non-selective, competitive opioid receptor antagonist.
List Price : 1639.00 USD

Dihydroalprenolol Hydrochloride, Levo-[Ring, Propyl-3H(N)]

Dihydroalprenolol hydrochloride, tritiated on the ring propyl group. Dihydroalprenolol (DHA) is an alprenolol derivative that binds to beta-adrenergic receptors and acts as a beta-adrenergic blocker.
Price Range : 980.00 USD - 2227.00 USD

Muscimol, 3-Hydroxy-5-Aminomethylisoxazole, [Methylene-3H(N)]

3H Muscimol radioligand. Muscimol acts as a potent selective agonist at GABAA receptors. It also acts as a partial agonist at GABAA-rho receptors.
Price Range : 1752.00 USD - 4383.00 USD

Citalopram, [N-Methyl-3H]

Citalopram, tritiated at the N-methyl group. Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidpressant drug, and has been shown to block the serotonin transporter (SERT, 5-HTT).
Price Range : 1108.00 USD - 2418.00 USD

Prazosin, [7-Methoxy-3H]

Prazosin, tritiated at the 7-methoxy position. Prazosin acts as an inverse agonist at the α1-adrenergic receptor.
Price Range : 698.00 USD - 5500.00 USD

Caffeine, [1-Methyl-14C]-, 50µCi (1.85MBq)

Caffeine, radiolabeled with C-14 at the 1-methyl position. Caffeine acts as a non-selective antagonist at adenosine receptors.
List Price : 816.00 USD

NAAG, [Glutamate-3,4-3H]

NAAG radioligand tritiated at the 3,4 position. NAAG is a peptide neurotransmitter that activates the metabotropic glutamate receptor type 3.
Price Range : 1294.00 USD - 2822.00 USD

Paroxetine, [Phenyl-6'-3H]

Paroxetine (Paxil), tritiated at the phenyl-6' position. Paroxetine is a selective serotonin reuptake inhibitor (SSRI).
Price Range : 620.00 USD - 2762.00 USD

Colchicine, [ring C, Methoxy-3H]-, 250µCi (9.25MBq)

Colchicine, tritiated at the ring C methoxy- position. Colchicine binds tubulin to prevent microtubule polymerization, and is used to treat gout.
List Price : 1756.00 USD

Vinblastine Sulphate, [G-3H]

Vinblastine sulphate, tritiated. Vinblastine binds to tubulin and inhibits microtubule formation.
Price Range : 1530.00 USD - 5700.00 USD

Rosiglitazone, DL- [3H]-

Tritiated DL-Rosiglitazone (Avandia). Rosiglitazone acts as a selective agonist at peroxisome proliferator-activated receptors (PPARs).
List Price : 1405.00 USD

Ascorbic Acid, L-[1-14C]-,>97%, 50µCi (1.85MBq)

L-Ascorbic acid (reduced form of vitamin C; ascorbate), labeled with C-14 at the 1- position. L-ascorbic acid is a vitamin that binds and is transported through sodium-dependent vitamin C transporters (SVCT1 and SCVT2).
List Price : 912.00 USD

CGS 21680, [Carboxyethyl-3H(N)]

CGS 21680, tritiated at the carboxyethyl group. CGS 21680 acts as an agonist for the adenosine A2A receptor, but can also bind adenosine A1 and A3.
Price Range : 1831.00 USD - 4415.00 USD

(-)-CGP-12177, [5,7-3H]

(-)-CGP-12177 radioligand tritiated at the 5,7 position. CGP-12177 acts as an antagonist at the β1- and β2-adrenoceptors and a partial agonist at β3-adrenoceptors.
Price Range : 512.00 USD - 1274.00 USD

Chloramphenicol, [Ring-3,5-3H]

Chloramphenicol, tritiated at the ring-3,5 position. Chloramphenicol is a broad spectrum antibiotic that binds to a receptor site on the 50S subunit of the bacterial ribosome, inhibiting peptidyl transferase.
Price Range : 1884.00 USD - 4131.00 USD

Bradykinin, [2,3-Prolyl-3,4-3H(N)]

Bradykinin, tritiated at the 2,3-prolyl-3,4 position. Bradykinin is the endogenous ligand that activates bradykinin B1 and B2 receptors.
Price Range : 1759.00 USD - 4016.00 USD

Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) (DPDPE)

2-D-Penicillamine, 5-D-Penicillamine (DPDPE), tritiated on the tyrosyl group. Cyclic peptide, sequence: Tyr-D-Pen-Gly-Phe-D-Pen-OH. DPDPE is a synthetic enkephalin opioid peptide that acts as an agonist at delta opiate receptors (δ-opioid receptor, DOR).
Price Range : 971.00 USD - 4717.00 USD

Dihydroxyphenylethylamine, 3,4-[7-3H]

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the 7 position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors.
Price Range : 801.00 USD - 2247.00 USD

Ethylcarboxamidoadenosine, 5`-N-[Adenine-2,8-3H]-, 250µCi (9.25MBq)

5'-N-Ethylcarboxamidoadenosine (NECA), tritiated at the adenine-2,8 position. 5'-N-Ethylcarboxamidoadenosine is an adenosine analog that acts as an agonist at adenosine receptors A1, A2A, and A3.
List Price : 1581.00 USD

"Ligands" 1-50 of 125 Products and Services

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