Iodinated Compounds

OF

We provide 125I- and 131I-labeled compounds, including radioligands specific for receptor/ligand characterization for drug discovery/development and receptor distribution. Because 125I and 131I are gamma emitters, they can be counted directly without requiring scintillant. Additionally, because 125I emits Auger electrons, counting in a liquid scintillation counter is also possible.

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Application
  • Drug Discovery & Development (190)
Concentration
  • 1.0 - 10 (1)
  • 1.11 (1)
  • 1.12 (2)
  • 1.14 (1)
  • 100 - 1000 (1)
  • 13.3 (1)
  • 152 (1)
  • 164 (2)
  • 169 (2)
  • 170.1 (2)
  • 171 (1)
  • 171.9 (2)
  • 172.5 (3)
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  • 182 (2)
  • 184.9 (2)
  • 2.93 (2)
  • 236 (3)
  • 3.06 (1)
  • 3.2 (1)
  • 3.22 (1)
  • 33.7 (2)
  • 345 (4)
  • 353 (5)
  • 40.7 (1)
  • 41.4 (3)
  • 42.5 (1)
  • 45.7 (2)
  • 50 (2)
  • 6.05 (1)
  • 77.7 (1)
  • 79.2 (2)
  • 83.8 (1)
  • 85.1 (1)
  • 86.3 (1)
  • 87.2 (1)
  • 87.4 (1)
  • 87.6 (1)
  • 87.9 (1)
  • 88.5 (1)
  • 93.2 (2)
  • <1.0 (4)
  • <100 (2)
Detection Method
  • Radiometric (206)
Label Position
  • Nominally Labeled (192)
  • Specifically Labeled (17)
Product Family
  • NEN Radiolabeled Ligands (204)
Radionuclide
  • 125I (207)
Receptor Type
  • 5-Hydroxytryptamine (4)
  • Adenosine (2)
  • Adrenoceptors (5)
  • Angiotensin (5)
  • Apelin (3)
  • Bombesin (4)
  • Calcitonin (6)
  • Calcium (4)
  • Chemokine (15)
  • Cholecystokinin (2)
  • Corticotropin-Releasing Factor (3)
  • Dopamine (4)
  • Endothelin (3)
  • Epidermal Growth Factor (4)
  • Galanin (2)
  • Ghrelin (2)
  • Glucagon (6)
  • Gonadotropin-releasing Hormone (2)
  • Growth Hormone (2)
  • Histamine (1)
  • Insulin (5)
  • Insulin-like Growth Factor (2)
  • Interleukin (4)
  • Melanin-Concentrating Hormone (2)
  • Melanocortin (4)
  • Melatonin (3)
  • Motilin (2)
  • Natriuretic Peptide Receptor (2)
  • Neuropeptide Y (6)
  • Neurotensin (2)
  • Nicotinic (7)
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  • Oxytocin (3)
  • Peptide P518 (2)
  • Platelet-Derived Growth Factor (1)
  • Potassium (2)
  • SK channels (2)
  • Somatostatin (4)
  • Tachykinin (6)
  • Thyroid Hormone (6)
  • Transforming Growth Factor (3)
  • Tumor Necrosis Factor (3)
  • Urotensin (2)
  • Vascular Endothelial Growth Factor (2)
  • Vasoactive Intestinal Peptide (4)
  • Vasopressin (4)
Therapeutic Area
  • Angiogenesis (16)
  • Cancer (25)
  • Cardiovascular (46)
  • CNS & Neurologic (90)
  • Diabetes (21)
  • Gastrointestinal (29)
  • Inflammation (73)
  • Metabolic Disorders (50)
  • Obesity (13)
  • Pain (22)
Volume
  • 0-50 (168)
  • 51-100 (15)
  • 101-150 (1)
  • 201-250 (14)
  • 451-500 (11)

"Iodinated Compounds" 1-50 of 209 Products and Services

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Fractalkine (human, recombinant), 10µCi

NEX368 Fractalkine is the first member of a new class of chemokines. [125I]-Fractalkine binds with high affinity to the CX3CR1 receptor. [125I]-Fractalkine will be useful for the localization and characterization of CXCR1 receptors.

List Price: 793.00 USD

QRFP-43, [125I], Human Radioligand, 25µCi (925kBq)

QRFP-43 is a 43 amino acid polypeptide starting from N-terminal pyroglutamic acid and ending at C-terminal arginine-phenylalanine-amide. The intravenous administration of QRFP-43 caused the release of aldosterone, suggesting that QRFP and its receptor have a regulatory function in the rat adrenal gland.

List Price: 2252.00 USD
List Price: 1820.00 USD

Apamin [125I]His18-NH2, 50µCi

NEX242 [125I]-Apamin is a K+ channel antagonist and can be used in the detection and quantification of K+ channel receptors. [125I]-Apamin has been used in receptor binding assays and in autoradiography.

List Price: 1286.00 USD

Bombesin (6-14), D-Tyr6[125I], 10µCi

NEX377 [D-Tyr6[125I]-, βAla11, Phe13, Nle14]-Bombesin (6-14) is a high affinity agonist to the human Orphan Bombesin Receptor Subtype 3 (hBRS-3).
[D-Tyr6[125I]-, bAla11, Phe13, Nle14]-Bombesin (6-14) will be a useful tool to study the pharmacology of this orphan receptor as well as the natural ligand for this receptor.

List Price: 1098.00 USD
List Price: 2008.00 USD

Sauvagine, [125I]-Tyr0], 50µCi

NEX306 [125I]Tyr0-Sauvagine has been shown to be active in receptor binding assays and has been used for receptor autoradiography.

List Price: 1874.00 USD

Lysergic Acid Diethylamide, 2-[125I]iodo-(+), 10µCi

NEX199 Preparations have been shown to be active in binding to the serotonin receptors. LSD affects a large number of the G protein coupled receptors, including all dopamine receptor subtypes, and all adrenoreceptor subtypes, as well as many others. LSD binds to most serotonin receptor subtypes except for 5-HT3 and 5-HT4.

List Price: 762.00 USD
List Price: 802.00 USD

ANGIOTENSIN II (human), [125I]-Tyr4 -50 μCi

NEX105 Packaged lyophilized from phosphate-buffered saline containing glycine, BSA and Trasylol®

List Price: 1759.00 USD

ANGIOTENSIN I (human), [125I]Tyr4-, 10µCi (370kBq), Species Activity:2200Ci (81.4TBq/mmol)

NEX101 Angiotensin, a protein, causes blood vessels to constrict, and drives blood pressure up. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin also stimulates the release of aldosterone from the adrenal cortex.

List Price: 742.00 USD

TRIIODOTHYRONINE, ([125I]-Reverse T3), L-3,3`,5`-[125I]-, 250µCi (9.25MBq)

NEX109 L-3,5-Diiodothyronine is radioiodinated with no carrier added 125I using a modification of the Hunter and Greenwood method and is purified by reversed phase HPLC.

List Price: 855.00 USD
List Price: 2438.00 USD

Atrial Natriuretic Factor (rat), [125I]Tyr28], 50 µCi

NEX228 Atrial natriuretic factor (ANF) is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells.

List Price: 2300.00 USD

Epidermal Growth Factor (Murine), [125I]-,10µCi

Epidermal growth factor or EGF is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR.

List Price: 692.00 USD

Iodo-Melatonin, 2-[125I], 50µCi

NEX236 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

List Price: 856.00 USD

Thyroxine, ([125I]-T4), L-[125I]-, 250µCi (9.25MBq), Specific Activity: 135-165µCi (5.00-6.11MBq)/µg

NEX111 L-3,5-Diiodothyronine is radioiodinated with no carrier added 125I using a modification of the Hunter and Greenwood method and is purified by reversed phase HPLC.

List Price: 841.00 USD

α-Bungarotoxin, [125I]-Tyr54-, High Specific Activity, 250 µCi

α-bungarotoxin extracted from venom of the Taiwanese banded krait (Bungarus multicinctus) binds the nicotinic acetylcholine receptor found at the neuromuscular junction and the 7 nicotinic acetylcholine receptor in the brain.

List Price: 1756.00 USD

Angiotensin II, [125I]-Sar1, Ile8], 50µCi

NEX248 [125I]-Sar1-Ile8-Angiotensin II is an angiotensin receptor antagonist which binds to a single class of receptors. [125I]-Sar1-Ile8-Angiotensin II is useful for studying AII receptors when an antagonist ligand is preferred, for receptor localization studies using autoradiographic techniques and for drug screening programs.

List Price: 1976.00 USD

Glucagon, Receptor Grade, [125I]-, 10µCi

NEX207 Glucagon is radioiodinated with no carrier added 125I by a lactoperoxidase procedure and is purified by reversed phase HPLC. [125I]-Glucagon consists of an approximately 1:1 ratio of Tyr10 and Tyr13 labeled glucagon. Met27 is in its native thioether form.

List Price: 890.00 USD

Insulin-like Growth Factor-I (human, recombinant), 25µCi

NEX241 IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signalling pathway post GH receptor including SHP2 and STAT5B.

List Price: 1434.00 USD

LH-RH, [125I]-[D-Trp6]-, 50µCi

NEX365 [125I]-[D-Trp6]-LH-RH will be useful for receptor binding studies in cell lines and tissue cultures.

List Price: 2115.00 USD

Interleukin-1β (human, recombinant), [125I], 5µCi

NEX232 Interleukin-1 (IL-1) refers to a group of three polypeptides (interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra)), that play a central role in the regulation of immune and inflammatory responses.

IL-1β is a pro-inflammatory cytokine involved in immune defense against infection.

List Price: 841.00 USD

VEGF (human, recombinant), ([125I]-VEGF), 5µCi

NEX328 [125I]-VEGF (human, recombinant), produced from a precursor obtained from an E. coli expressed gene, has been shown to be useful in receptor binding and autoradiography for localization and characterization of VEGF receptors. [125I]-VEGF will help elucidate the role of VEGF in normal and pathological angiogenesis.

List Price: 607.00 USD

Adrenomedullin (human), (13-52), [125I] Tyr-, 25 μCi

NEX385 Adrenomedullin (13-52) [125I] Tyr-, a 40 amino acid peptide with one intramolecular disulfide bridge, is a high affinity ligand for the adrenomedullin receptor. Typical Kd values for the CRLR/RAMP2 heterodimers are in the range of 10 to 50 pM.

List Price: 2051.00 USD

Bombesin (6-14), D-Tyr6[125I], 25µCi

NEX377 [D-Tyr6[125I]-, βAla11, Phe13, Nle14]-Bombesin (6-14) is a high affinity agonist to the human Orphan Bombesin Receptor Subtype 3 (hBRS-3).
[D-Tyr6[125I]-, bAla11, Phe13, Nle14]-Bombesin (6-14) will be a useful tool to study the pharmacology of this orphan receptor as well as the natural ligand for this receptor.

List Price: 2026.00 USD

Amylin (rat), [125I], 100 µCi

Amylin (rat), [125I] NEX448 This product is similar to GE Healthcare's IM234. This product has been used to study the following disease states, Diabetes type 2, Obesity and Pain. Receptor Rat amylin binds receptors AMY1, AMY2, and AMY3. Receptor activity modifying protein (RAMP) pairs with the calcitonin receptor (CT). The RAMP1-CT pair is AMY1; RAMP2, AMY2; and RAMP3, AMY3.

List Price: 4445.00 USD
List Price: 690.00 USD

α-Bungarotoxin, [125I]-Tyr54-, 500µCi (18.5MBq)

α-bungarotoxin extracted from venom of the Taiwanese banded krait (Bungarus multicinctus) binds the nicotinic acetylcholine receptor found at the neuromuscular junction and the 7 nicotinic acetylcholine receptor in the brain.

List Price: 1914.00 USD

[125I]- Epidermal Growth Factor (h, r), 25 µCi

NEX428 Epidermal Growth Factor is radioiodinated with no carrier added 125I using a lactoperoxidase procedure and is purified by reversed phase HPLC.

List Price: 1385.00 USD

Ghrelin (human), [His[125I]], 10µCi

NEX388 Ghrelin is an acylated endogenous peptide which stimulates the release of growth hormone from the pituitary through an orphan G-protein-coupled receptor (GHS-R)7. Ghrelin is an appetite inducing hormone produced in the stomach and the upper portion of the small intestine. [ [125I]His ]Ghrelin (human), binds to GHS-R with high affinity.

List Price: 1169.00 USD

Goat anti-rabbit IgG, [125I], 100µCi (3.7MBq)

Affinity purified goat anti-rabbit IgG is radioiodinated with no carrier added 125I using a modification of the Hunter and Greenwood method1 and is purified by gel filtration chromatography. This method predominantly labels tyrosine residues.

List Price: 693.00 USD

IL-6 (human, recombinant), [125I], 5µCi

NEX269 Interleukin-6 (IL-6) is a protein that in humans is encoded by the IL6 gene. IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation.

List Price: 1066.00 USD
List Price: 1981.00 USD

Iodo-Melatonin, 2-[125I], 100µCi

NEX236 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

List Price: 1395.00 USD

IP-10 (human, recombinant), [125I]-, Bolton-Hunter Labeled, 25µCi

NEX348 IP-10 acts at the CXCR3 receptor and attracts T cells, particularly activated T cells.

List Price: 1562.00 USD
List Price: 875.00 USD

Somatostatin, [125I]Tyr11, 50µCi

NEX389 Somatostatin is a cyclic neuropeptide found in the brain, pancreas and hypothalamus and inhibits the release of growth hormone. [125I ] Tyr11 somatostatin binds to the receptors on RINm5F insolinoma cells with high affinity and inhibits the secretion of insulin from pancreatic b cells.

List Price: 1824.00 USD
List Price: 1689.00 USD

TNF-α (human, recombinant), [125I]-rTNFα, 10µCi

NEX257 [125I]-rTNFa is used in the study of TNFa receptors, and for radioimmunoassay.

List Price: 848.00 USD

Thyroxine, ([125I]-T4), L-[125I]-, 500µCi (18.5MBq), Specific Activity: 135-165µCi (5.00-6.11MBq)/µg

NEX111 L-3,5-Diiodothyronine is radioiodinated with no carrier added 125I using a modification of the Hunter and Greenwood method and is purified by reversed phase HPLC.

List Price: 1572.00 USD

2`-Deoxycytidine-5`-triphosphate, 5-[125I]iodo-, Tetraammonium Salt, 1 mCi (37 MBq),

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.

List Price: 2374.00 USD

TRIIODOTHYRONINE, ([125I]-Reverse T3), L-3,3`,5`-[125I]-, 500µCi (18.5MBq)

NEX109 L-3,5-Diiodothyronine is radioiodinated with no carrier added 125I using a modification of the Hunter and Greenwood method and is purified by reversed phase HPLC.

List Price: 1976.00 USD
List Price: 1565.00 USD

"Iodinated Compounds" 1-50 of 209 Products and Services

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