PerkinElmer

Iodinated Compounds

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We provide 125I- and 131I-labeled compounds, including radioligands specific for receptor/ligand characterization for drug discovery/development and receptor distribution. Because 125I and 131I are gamma emitters, they can be counted directly without requiring scintillant. Additionally, because 125I emits Auger electrons, counting in a liquid scintillation counter is also possible.

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Application
  • Drug Discovery & Development (168)
Concentration
  • 1.0 - 10 mCi/mL (1)
  • 1.12 mCi/mL (2)
  • 1.14 mCi/mL (1)
  • 13.3 MBq/mL (1)
  • 152 µCi/mL (1)
  • 170.1 µCi/mL (2)
  • 171 µCi/mL (1)
  • 171.9 µCi/mL (2)
  • 172.5 µCi/mL (3)
  • 173.9 µCi/mL (1)
  • 182 µCi/mL (2)
  • 2.93 MBq/mL (2)
  • 236 µCi (3)
  • 3.06 MBq/mL (1)
  • 3.22 MBq/mL (1)
  • 33.7 µCi (2)
  • 345 µCi/mL (4)
  • 353 µCi/mL (5)
  • 41.4 µCi/mL (3)
  • 42.5 µCi/mL (1)
  • 45.7 µCi/mL (2)
  • 50 µCi/mL (1)
  • 6.05 MBq/mL (1)
  • 79.2 µCi/mL (2)
  • 83.8 µCi/mL (1)
  • 85.1 µCi/mL (1)
  • 86.3 µCi (1)
  • 87.2 µCi/mL (1)
  • 87.4 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • 87.9 µCi/mL (1)
  • 88.5 µCi/mL (1)
  • 93.2 µCi/mL (2)
  • <1.0 µCi/mL (4)
  • <100 µCi/mL (2)
Detection Method
  • Radiometric (178)
Label Position
  • Nominally Labeled (166)
  • Specifically Labeled (15)
Product Brand Name
  • NEN Radiolabeled Ligands (178)
Radionuclide
  • 125I (180)
Receptor Type
  • 5-Hydroxytryptamine (2)
  • Adenosine (2)
  • Adrenoceptors (4)
  • Angiotensin (5)
  • Apelin (3)
  • Bombesin (4)
  • Calcitonin (3)
  • Calcium (4)
  • Chemokine (12)
  • Cholecystokinin (2)
  • Corticotropin-Releasing Factor (3)
  • Dopamine (2)
  • Endothelin (3)
  • Epidermal Growth Factor (4)
  • Ghrelin (2)
  • Glucagon (6)
  • Gonadotropin-releasing Hormone (2)
  • Growth Hormone (2)
  • Histamine (1)
  • Insulin (5)
  • Insulin-like Growth Factor (2)
  • Interleukin (4)
  • Melanin-Concentrating Hormone (2)
  • Melanocortin (4)
  • Melatonin (3)
  • Motilin (2)
  • Neuropeptide Y (6)
  • Neurotensin (2)
  • Nicotinic (7)
  • Orexin (2)
  • Oxytocin (3)
  • Peptide P518 (2)
  • Platelet-Derived Growth Factor (1)
  • Potassium (2)
  • SK channels (2)
  • Somatostatin (4)
  • Tachykinin (6)
  • Thyroid Hormone (6)
  • Transforming Growth Factor (3)
  • Urotensin (2)
  • Vasoactive Intestinal Peptide (4)
  • Vasopressin (4)
Therapeutic Area
  • Angiogenesis (12)
  • Cancer (22)
  • Cardiovascular (41)
  • CNS & Neurologic (84)
  • Diabetes (14)
  • Gastrointestinal (25)
  • Inflammation (60)
  • Metabolic Disorders (45)
  • Obesity (11)
  • Pain (22)
Volume
  • 0-50 (19)
  • 51-100 (1)
  • 201-250 (1)

"Iodinated Compounds" 1-50 of 181 Products and Services

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CGRP (human), [125I]-, 50µCi

NEX354 Human CGRP binds to human CGRP receptors in the central nervous system and peripheral nervous system. [125I]-CGRP (human) will be useful in the characterization of CGRP receptors.
List Price : 1840.00 USD

LH-RH, [125I]-[D-Trp6]-, 50µCi

NEX365 [125I]-[D-Trp6]-LH-RH will be useful for receptor binding studies in cell lines and tissue cultures.
List Price : 2326.00 USD
List Price : 882.00 USD

Endothelin-1 (human, porcine), [125I]Tyr13, 5µCi

NEX259 [125I]-ET-1 will be useful as a tracer in RIA's for endothelin, and as a high specific activity ligand in receptor studies encompassing the areas of vasoconstriction and stroke, smooth muscle and renal function, and in the study of neurotransmitters in the CNS.
List Price : 869.00 USD

Ghrelin (human), [His[125I]], 10µCi

NEX388 Ghrelin is an acylated endogenous peptide which stimulates the release of growth hormone from the pituitary through an orphan G-protein-coupled receptor (GHS-R)7. Ghrelin is an appetite inducing hormone produced in the stomach and the upper portion of the small intestine. [ [125I]His ]Ghrelin (human), binds to GHS-R with high affinity.
List Price : 1285.00 USD

QRFP-43, [125I], Human Radioligand, 25µCi (925kBq)

QRFP-43 is a 43 amino acid polypeptide starting from N-terminal pyroglutamic acid and ending at C-terminal arginine-phenylalanine-amide. The intravenous administration of QRFP-43 caused the release of aldosterone, suggesting that QRFP and its receptor have a regulatory function in the rat adrenal gland.
List Price : 2477.00 USD
List Price : 1441.00 USD

Epidermal Growth Factor (Murine), [125I]-,10µCi

Epidermal growth factor or EGF is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR.
List Price : 761.00 USD
List Price : 1098.00 USD

Somatostatin, [125I]Tyr11, 10µCi

NEX389 Somatostatin is a cyclic neuropeptide found in the brain, pancreas and hypothalamus and inhibits the release of growth hormone. [125I ] Tyr11 somatostatin binds to the receptors on RINm5F insolinoma cells with high affinity and inhibits the secretion of insulin from pancreatic b cells.
List Price : 861.00 USD
List Price : 957.00 USD

Endothelin-1 (human, porcine), [125I]Tyr13, 10µCi

NEX259 [125I]-ET-1 will be useful as a tracer in RIA's for endothelin, and as a high specific activity ligand in receptor studies encompassing the areas of vasoconstriction and stroke, smooth muscle and renal function, and in the study of neurotransmitters in the CNS.
List Price : 1197.00 USD

Angiotensin II, [125I]-Sar1, Ile8], 50µCi

NEX248 [125I]-Sar1-Ile8-Angiotensin II is an angiotensin receptor antagonist which binds to a single class of receptors. [125I]-Sar1-Ile8-Angiotensin II is useful for studying AII receptors when an antagonist ligand is preferred, for receptor localization studies using autoradiographic techniques and for drug screening programs.
List Price : 2174.00 USD

Vasoactive Intestinal Polypeptide (human, porcine, rat), [125I], 10µCi

VIP is radioiodinated with no carrier added 125I using a modification of the Hunter and Greenwood method and purified by reversed phase HPLC. This method predominantly labels tyrosine residues. 
List Price : 915.00 USD

α-MSH, Nle4, D-Phe7, [125I], 10µCi

NEX352 α-MSH is a highly potent and metabolically stable analog of α-MSH.7 [125I]-[Nle4, D-Phe7]-α-MSH can be used to label all subtypes of melanocortin receptors with high affinity and low non-specific binding.
List Price : 987.00 USD

Adenosine 3',5'-cyclic Phosphoric Acid, 2`-O-succinyl [125I]-Iodotyrosine Methyl Ester-, 1µCi

Adenosine 3',5'-cyclic Phosphoric Acid, 2'-O-succinyl, [125I]-Iodotyrosine Methyl Ester- Adenosine is an inhibitory neurotransmitter, believed to play a role in promoting sleep and suppressing arousal, with levels increasing with each hour an organism is awake.
List Price : 361.00 USD

Adenosine 3',5'-cyclic Phosphoric Acid, 2`-O-succinyl [125I]-Iodotyrosine Methyl Ester-, 5µCi

Adenosine 3',5'-cyclic Phosphoric Acid, 2'-O-succinyl, [125I]-Iodotyrosine Methyl Ester- Adenosine is an inhibitory neurotransmitter, believed to play a role in promoting sleep and suppressing arousal, with levels increasing with each hour an organism is awake.
List Price : 1146.00 USD
List Price : 1685.00 USD

Peptide YY, (Porcine), ([125I]-PYY), 50µCi

NEX240 Synthetic Peptide YY is radioiodinated with no-carrier-added 125I using a modification of the chloramine-T method.
List Price : 2215.00 USD

Vasopressin, [125I]Tyr2, Arg8-, 50µCi (1.85MBq)

NEX128 [Arg8]-Vasopressin is radioiodinated using no carrier added 125I, by a modification of the Hunter and Greenwood method and is purified by reversed phase HPLC.
List Price : 2046.00 USD
List Price : 951.00 USD

[125I]Tyr0-Corticotropin Releasing Factor (ovine), 10 µCi

NEX217 Corticotropin-releasing hormone (CRH), originally named corticotropin-releasing factor (CRF), and also called corticoliberin, is a polypeptide hormone and neurotransmitter involved in the stress response.
List Price : 1140.00 USD
List Price : 2251.00 USD

Cholecystokinin Octapeptide, [125I]-, Bolton-Hunter Labeled, 50µCi

NEX203 CCK-8 mediates a number of physiological processes, including digestion and satiety. It is located in the small intestine, and detects the presence of fat in the chyme. As a neuropeptide, CCK mediates satiety by acting on the CCK receptors distributed widely throughout the central nervous system.
List Price : 3214.00 USD
List Price : 2557.00 USD

Neurokinin A, ([125I]-Substance K, 10µCi

NEX252 [125I]-NKA is a radioiodinated tachykinin which binds selectively to NK-2 receptors. Typical lots have been tested in a specific NK-2 radioreceptor assay. We do not recommend its use in a radioimmunoassay. The presence of a non-oxidized methionine typically leads to low antibody binding.
List Price : 779.00 USD
List Price : 898.00 USD

Iodo-Melatonin, 2-[125I], 250µCi

NEX236 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.
List Price : 2379.00 USD
List Price : 1858.00 USD

IP-10 (human, recombinant), [125I]-, Bolton-Hunter Labeled, 5µCi

NEX348 IP-10 acts at the CXCR3 receptor and attracts T cells, particularly activated T cells.
List Price : 708.00 USD

Goat anti-rabbit IgG, [125I], 250µCi (9.25MBq)

Affinity purified goat anti-rabbit IgG is radioiodinated with no carrier added 125I using a modification of the Hunter and Greenwood method1 and is purified by gel filtration chromatography. This method predominantly labels tyrosine residues.
List Price : 893.00 USD
List Price : 962.00 USD
List Price : 1513.00 USD
List Price : 1731.00 USD

Interleukin-1β (human, recombinant), [125I], 5µCi

NEX232 Interleukin-1 (IL-1) refers to a group of three polypeptides (interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β) and interleukin-1 receptor antagonist (IL-1Ra)), that play a central role in the regulation of immune and inflammatory responses.

IL-1β is a pro-inflammatory cytokine involved in immune defense against infection.

List Price : 925.00 USD

ACTH (1-39) 23Tyr [125I], 50 µCi

[125I]ACTH is lyophilized from an acetic acid solution (0.1%) containing bovine serum albumin (0.25%), lactose (5%), L-cysteine hydrochloride (0.1%) and aprotinin (0.3TIU/ml).
List Price : 4474.00 USD

Somatostatin, [125I]Tyr11, 50µCi

NEX389 Somatostatin is a cyclic neuropeptide found in the brain, pancreas and hypothalamus and inhibits the release of growth hormone. [125I ] Tyr11 somatostatin binds to the receptors on RINm5F insolinoma cells with high affinity and inhibits the secretion of insulin from pancreatic b cells.
List Price : 2007.00 USD
List Price : 2002.00 USD

Insulin (porcine), Receptor Grade, [125I]TyrA14], 50µCi

[125I]TyrA14 Insulin has been proven to be active in a receptor binding assay using cultured human fibroblasts as described.8 It may also be used in radioimmunoassay.
List Price : 2143.00 USD
List Price : 980.00 USD

2'-deoxycytidine-5'-triphosphate, 5-[125I]Iodo-

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
List Price : 1631.00 USD

α-MSH, Nle4, D-Phe7, [125I], 50µCi

NEX352 α-MSH is a highly potent and metabolically stable analog of α-MSH.7 [125I]-[Nle4, D-Phe7]-α-MSH can be used to label all subtypes of melanocortin receptors with high affinity and low non-specific binding.
List Price : 2213.00 USD
List Price : 1197.00 USD

Vasopressin, [125I]Tyr2, Arg8-, 10µCi (370kBq)

NEX128 [Arg8]-Vasopressin is radioiodinated using no carrier added 125I, by a modification of the Hunter and Greenwood method and is purified by reversed phase HPLC.
List Price : 869.00 USD

ProTx-II (tarantula), [125I], 50µCi

[125I]-ProTx-II (tarantula) NEX450010UC. This product extends offerings for sodium Ion channels, the disease state is Pain. ProTx-II selectively alters the rate of activation for voltage-gated sodium channels Nav1.7. Related products Sodium Channel and Potassium Channel
List Price : 3162.00 USD
List Price : 1903.00 USD
List Price : 1731.00 USD

"Iodinated Compounds" 1-50 of 181 Products and Services

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