PerkinElmer

In Vivo Imaging Reagents

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Our comprehensive suite of fluorescent and bioluminescent in vivo imaging reagents enables unmatched imaging of a broad-range of disease-related biomarkers and pathways for your research. Our optical reagents, labeling kits and dyes have been optimized on our IVIS® in vivo imaging platform. In addition to our in vivo optical imaging reagents, we offer radioimaging nuclides for PET imaging studies.

  • Fluorescent agents, Dyes, Labeling Kits, and Nanoparticles, and Fluorescent Imaging Application Panels
  • Bioluminescent oncology cell lines created using luciferase (Red-FLuc) vector for ultra bright sensitivity
  • Bioluminescent bacterial cell lines
  • Bioluminescent substrates including D-Luciferin K+ salt and RediJect Luciferin in ready-to-use injectable format
  • Radioimaging reagents

Download our interactive In Vivo Solutions eBook to learn more

For research use only. Not for use in diagnostic procedures.

Business Insights (5)
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1-5 of 5 Business Insights

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  • Application Note

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • Application Note

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • Application Note

    NIR Fluorescent Cell Labeling for In Vivo Cell Tracking (VivoTrack 680)

    Fluorescent dyes have been used for many years to label cells for microscopy studies, and a variety of dyes in the visible fluorescence spectrum are available to label different cellular compartments and organelles. Efficient delivery of the fluorophore to the cell without excessively modifying surface proteins or perturbing cell function is the major biotechnological challenge. In addition, researchers have taken on the challenge of in vivo imaging, focusing on near infrared (NIR) dyes that fluoresce in a spectral region better suited for in vivo imaging due to reduced background and higher tissue penetration.

  • Application Note

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • Poster

    Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

    Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more important to integrate safety/toxicology assessments earlier in the drug development process. There are a variety of traditional serum markers, tailored mechanistically to specific tissues, however there are no current non-invasive assessment tools that are capable of looking broadly at in situ biological changes in target and non-target tissue induced by chemical insult.

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1-12 of 113 Products & Services

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  • XenoLight D-Luciferin K+ Salt

    XenoLight D-Luciferin - K+ Salt Bioluminescent Substrate

    Luciferin is essential in performing your bioluminescent assays, and the quality of your research will depend on the quality of your luciferin. Whether used to perform in vitro assays, or to monitor light production in vivo, PerkinElmer’s high quality luciferin is available at an affordable price.
    Price Range : 268.00 USD - 2286.00 USD
  • S. aureus Bioluminescent Bacteria

    Staphylococcus aureus - Xen8.1

    Staphylococcus aureus - Xen8.1 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from the parental strain 8325-4. Staph. aureus-Xen8.1 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
  • S. aureus Bioluminescent Bacteria

    Staphylococcus aureus - Xen40

    Staphylococcus aureus - Xen40 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from the parental strain UAMS-1. Staph. aureus-Xen40 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
  • Measuring DILI using Toxicology fluorescent agent imaging panel

    Fluorescent Imaging Agent Panel – Toxicology

    Detect drug induced liver injury (DILI) early in the drug discovery process with PerkinElmer’s Toxicology Fluorescent Imaging Agent Panel.
    List Price : 3372.00 USD
  • VivoTrack-680 Fluorescent Labeling Kit - Standard Kit NEV12000

    VivoTrack 680 NIR Fluorescent Imaging Agent (Standard Kit)

    Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.
    List Price : 273.00 USD
  • In vivo Fluorescent Agents

    IntegriSense 750 Fluorescent Imaging Agent

    Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications. 
    List Price : 717.00 USD
  • In vivo Fluorescent Agents

    TLectinSense 680 Fluorescent Imaging Agent

    Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications. 
    List Price : 631.00 USD
  • Bioware Bioluminescent Bacteria

    Salmonella typhimurium - Xen 33

    Salmonella typhimurium - Xen33 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from the parental strain FDA 1189. S. typhimurium-Xen33 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
  • Bioware Bioluminescent Bacteria

    Shigella dysenteriae - Xen27

    S. dysenteriae - Xen27 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from the 88A6205 clinical isolate. S. dysenteriae-Xen27 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
  • Bioware Bioluminescent Bacteria

    Yersinia enterocolitica - Xen24

    Yersinia enterocolitica - Xen24 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from the 91A1854 clinical isolate. Y. enterocolitica-Xen24 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
  • Bioware Bioluminescent Bacteria

    Listeria monocytogenes - Xen19

    Listeria monocytogenes - Xen19 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from a parental strain from the American Type Culture Collection, used under license. L. monocytogenes-Xen19 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
  • In vivo Fluorescent Agents

    AngioSense 680EX Fluorescent Imaging Agent

    Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.
    List Price : 601.00 USD
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