PerkinElmer
  • Research Areas
  • Drug Discovery & Development

High Throughput and Phenotypic Screening

Complete solutions for high-throughput and phenotypic screening – together, this spells discovery.

To get drugs to market that much sooner, you need to accelerate your workflow, upstream and downstream. Our screening solutions are a crucial component in that effort: State-of-the art imaging and detection instruments, assay technologies, reagents, versatile automation systems, and powerful informatics solutions working together to ensure consistent, accurate, physiologically relevant results – with one-of-a-kind analytics to wrest more meaning from your findings. Amplify your phenotypic or target-based screens to identify hits and lead compounds in small and focused or high-throughput volumes by using of complete suite of instrument, reagents and informatics solutions:

  • Screening assays for molecular targets
  • High content screening using cellular models
  • High content analysis of microtissues and 3D cell culture
  • Orthogonal testing and secondary screening
  • Selectivity screening
  • Large volume data capture and rapid analysis

Applications and Techniques

Microplate Reader Assays

Whether you are working on basic research, assay development, or high-throughput screening, you need accurate data you can trust, every time. Our multimode microplate readers, Alpha®, LANCE® Ultra TR-FRET, DELFIA® TRF, and Luminescence assays and microplates provide excellent sensitivity and performance, and can help you save time and headaches. We offer a wide range of biochemical and cell-based screening assays, all of which are validated on our microplate readers, so you can be confident that you will get reliable results, service and support.

For research use only. Not for use in diagnostic procedures.

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High Content Screening & Analysis

High-Content Analysis (HCA) or High-Content Screening (HCS) combines high-throughput automated imaging and analysis to extract quantitative multi-parametric data at the single-cell level. Originally developed as a complementary technology to traditional biochemical high-throughput screening (HTS) in drug discovery, today high-content screening is established in a far broader area of the life science space as an unbiased imaging method to assess cellular function.

High-content screening offers a number of advantages over traditional techniques:

  • More information from cellular samples
    Fully automated imaging and unbiased quantitative image analysis exploits the full potential of microscopy, improving your lab’s throughput and productivity.
  • More meaningful results
    Screening can be performed in more physiologically and biologically relevant systems than in classical biochemical assays.
  • More questions answered simultaneously
    Data sets are more information-rich compared to non-imaging read-outs, allowing a number of questions to be answered simultaneously.

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Screening Software

Companies that most quickly and accurately identify key drug discovery parameters will win the race to promote the most appropriate targets and develop medicines to affect them. PerkinElmer Screening and Lead Discovery solutions let scientists manage screening data from raw data import, QC, analytics and visualization to publication and management.

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Featured Products

Drug Discovery Screening Reagents

Drug discovery is a complex, costly and time-consuming undertaking. For research scientists, screening potential candidates is where the journey begins.

Your job is to move from target to hit to candidate quickly and efficiently – with as little wasted resources as possible. Our drug discovery screening reagents do just that. Whether you are doing high throughput screening or focused screening, we offer a wide range of validated reagents and kits in Alpha chemiluminescent, LANCE® TR-FRET, DELFIA® TRF, and other assay technologies to suit you screening assay needs.

Accelerate your workflow with our drug discovery screening reagents while getting consistent, accurate and physiologically relevant results.

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Microplates

A microplate is a critical part of your discovery process.  Microplates have the capability to generate valuable, information-rich data that bring great insights into discovery screening.

Microplate planarity and inaccurate data collection are common issues caused by microplates that are not carefully designed for the unique challenges of sample screening which can result in missed data points, sample re-screening, missed project timelines, and ultimately higher costs.

Drawing on many years of experience in high throughput screening, PerkinElmer’s expert team has developed microplates that address the most common screening challenges. Our microplates have been engineered to deliver the highest quality data for high throughput screening as well as imaging applications.

  • Footprint dimensions meet the SBS industry standard, guaranteeing compatibility with microplate-based instrumentation
  • Carefully monitored microplate planarity to ensure superb data and image acquisition
  • Custom microplate services including barcoding, custom packaging, as well as plate surface coatings to fit your application
  • Full range of validated reagents and instruments to compliment microplates

By using PerkinElmer’s microplates specifically engineered for high throughput screening and imaging applications, you can be confident that you’ll acquire high quality results providing more information-rich data and experience fewer re-screens reducing your overall screening costs.

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Automation & Liquid Handling Instruments

With dedicated workstations designed for a diverse variety of applications, along with the ability to customize liquid handling workstations based on your needs, our innovative automated liquid handling solutions enable you to minimize errors, reduce hands-on time, and increase throughput and reproducibility. With flexibility in throughput, capacity and dynamic volume range, high quality manufacturing standards, and outstanding customer service and support, we offer solutions optimized to meet your laboratory’s needs.

From benchtop application-specific workstations to complex customized integrated solutions our liquid handing portfolio automates your science.

For research use only. Not for use in diagnostic procedures.

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PerkinElmer Signals Screening

Signals Screening is an intuitive, configurable, and flexible screening workflow processing engine on top of the unparalleled data visualization and analysis capabilities of TIBCO Spotfire. The initial offering of Signals Screening addresses three key drug discovery assays:
  • Basic Screening
  • High Content Screening (HCS)
  • Surface Plasmon Resonance (SPR)

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EnVision 2105 Multimode Plate Reader

The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

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EnSight Multimode Plate Reader

The EnSight multimode plate reader combines labeled & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.

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Operetta CLS High-Content Analysis System

Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.

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Opera Phenix High-Content Screening System

The Opera Phenix High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.

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Featured Content

High Throughput Quantification of Cytokine Biomarkers using LANCE Ultra TR-FRET Assays

See how our LANCE Ultra TR-FRET technology aids in anti-inflammatory drug development by providing a robust, reliable, high-throughput assay to screen for cytokine production.

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White Paper: Phenotypic Drug Discovery with High Content Screening

Today’s drug discovery strategies require candidate compounds to fail early and cheaply in the discovery stage, rather than late and expensively in the clinical phase.

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Alpha Technology – How It Works

Alpha technology is a homogenous bead-based assay technology that can be used to measure virtually any target, making it an easy, no-wash alternative for a wide range of research applications. Watch the video to see how it works.

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