PerkinElmer

GPCR

OF

Accelerate your research into G-protein-coupled receptors with integrated solutions for any GPCR target, including Gs-, Gq- and Gi-coupled receptors. Count on us to help you identify and monitor

  • Effects of GPCR pathway activation: intracellular calcium, cAMP, phospho-ERK, inositol phosphate
  • Reporter gene expression
  • Receptor ligand binding
  • GTP binding

Our state-of-the-art GPCR solutions portfolio is extensive and includes:

  • Scalable GPCR cellular imaging, detection instrumentation and liquid handling systems for radiometric fluorescence, luminescence or photometric detection
  • Optimized cell-based assay platforms
  • Versatile reagents—GPCR cell lines; frozen, ready-to-use cells; radioligands; ligands; cloned receptor membranes

  • Products and Services

  • Resources, Events & More

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Product Type
  • Accessories (6)
  • Instruments (5)
  • Reagents (109)
Application
  • cAMP (8)
  • Drug Discovery & Development (49)
  • Kinase (6)
  • Multiplexing (8)
  • Protein Analysis & Detection (12)
Assay Points
  • 100 (8)
  • 1000 (1)
  • 10000 (14)
  • 500 (13)
  • 50000 (14)
Assay Target
  • Akt1 (2)
  • Akt1/2 (1)
  • Akt1/2/3 (6)
  • cAMP (3)
  • CREB (2)
  • ERK1/2 (15)
Assay Target Class
  • GPCR (46)
  • Phosphoprotein (21)
  • Protein (6)
Assay Validated
  • Binding (35)
  • Calcium Fluorescence (4)
  • Calcium Luminescence (20)
  • cAMP (5)
  • Downstream Phosphorylation (4)
Automation Compatible
  • Yes (31)
Concentration
  • 1.0 - 10 mCi/mL (2)
  • 1.12 mCi/mL (2)
  • 171.9 µCi/mL (2)
  • 50 µCi/mL (1)
  • 83.8 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • <1.0 µCi/mL (1)
Detection Method
  • Absorbance (4)
  • Alpha (29)
  • Fluorescence (4)
  • Fluorescence Polarization (2)
  • Image-based Cytometry (1)
  • Label-free (2)
  • Luminescence (4)
  • Radiometric (21)
  • Time-Resolved Fluorescence (TRF) (6)
  • TR-FRET (2)
Experimental type
  • In vitro (24)
Format
  • Microplates (27)
Host Cell
  • 1321N1 (2)
  • A9 (1)
  • CHO-K1 (27)
  • HEK293 (23)
  • HT29 (1)
  • L Cells (1)
  • U373 (1)
  • UC11 (1)
Label Position
  • Generally Labeled (1)
  • Nominally Labeled (16)
  • Specifically Labeled (4)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)
Molecular modification
  • Phosphorylation (14)
Product Brand Name
  • AequoScreen (6)
  • AequoZen (14)
  • Alpha SureFire Ultra Multiplex (8)
  • AlphaLISA SureFire Ultra (3)
  • AlphaPlex (8)
  • AlphaScreen (1)
  • AlphaScreen SureFire (14)
  • cAMPZen (5)
  • EnSight (1)
  • EnSpire (3)
  • EnVision (3)
  • LANCE (1)
  • LANCE Ultra (1)
  • Membrane Target Systems (32)
  • NEN Radiochemicals (5)
  • NEN Radiolabeled Ligands (16)
  • OnPoint (3)
  • Victor (2)
  • ViewLux (1)
Radionuclide
  • 125I (16)
  • 3H (5)
Radioisotope
  • H-3 (5)
  • I-125 (16)
Receptor Type
  • 5-Hydroxytryptamine (1)
  • 5-Hydroxytryptamine (Serotonin) (4)
  • Adenosine (13)
  • Adrenergic (5)
  • Anaphylatoxin (1)
  • Calcitonin (2)
  • Cannabinoid (1)
  • Dopamine (1)
  • GABA (4)
  • Galanin (1)
  • Glucagon (2)
  • Histamine (1)
  • Insulin (2)
  • Melanocortin (2)
  • Motilin (2)
  • Neurotensin (2)
  • Opioid (6)
  • Peptide P518 (2)
  • Prostanoid (1)
  • Tachykinin (1)
  • Urotensin (1)
  • Vasoactive Intestinal Peptide (1)
  • Vasopressin (4)
Target Species
  • Human (11)
Therapeutic Area
  • Angiogenesis (1)
  • Cardiovascular (28)
  • Central Nervous System (33)
  • Diabetes (9)
  • Gastrointestinal (17)
  • Inflammation (32)
  • Metabolic (16)
  • Obesity (5)
  • Pain (15)
  • Renal (2)

"GPCR" 1-50 of 120 Products and Services

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EnVision_Alone_Left_Angle

EnVision Multilabel Plate Reader

The EnVision Multilabel Plate Reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.
EnSight multimode plate-reader

EnSight Multimode Plate Reader

The EnSight multimode plate reader combines labeled, label-free & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.

The ViewLux uHTS microplate imager is no longer available in EU. Please contact your local representative to discuss alternative products or visit our EnVision plate reader product page.

EnSpire Multimode Plate Reader

EnSpire® Multimode Plate Reader is designed to meet the demands of multi-user research environments, providing high performance technology and flexibility for a range of applications without compromising sensitivity. Combine this with our expertise and portfolio of reagents, PerkinElmer offers an unrivaled solution to your application needs.

EnSpire Alpha Plate Reader

The EnSpire Alpha Plate Reader provides proven Alpha technology to your lab at an affordable price and from the Alpha detection leader.
PerkinElmer

14C, 3H and 35S Custom Synthesis

PerkinElmer's experienced chemists will work with you, scientist to scientist, to design and prepare your radiochemical. You'll have access to PerkinElmer's extensive technical support resources, both during the specification process and after delivery, to ensure your custom product meets your exact specifications and application needs. We offer industry-leading turnaround times on quotations and deliveries worldwide-and highly competitive pricing.

Insulin (human, recombinant), [125I], 10 µCi

[125I]-Insulin (h) is suitable for the use in radioimmunoassay as well as receptor binding assay. [125I]-Insulin (h) is radioiodinated with no carrier added 125I using the LPO iodination procedure and is purified by reversed phase HPLC.
List Price : 1033.00 USD
Receptor-expressing cell lines

AequoZen Frozen cells, Adenosine α2A, Human Recombinant, HEK293

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 835.00 USD
Receptor-expressing cell lines

Adenosine A3, Human Recombinant, CHO-K1 AequoZen® Frozen cells

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 836.00 USD
PerkinElmer

Membrane Target Systems: Opioid Delta (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human opioid delta receptor, 400 units.
List Price : 891.00 USD

2'-deoxycytidine-5'-triphosphate, 5-[125I]Iodo-

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
List Price : 1631.00 USD

LANCE Ultra cAMP Detection Kit

The LANCE® Ultra cAMP assay is a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay designed to measure cAMP produced upon modulation of adenylyl cyclase activity by G-protein coupled receptors (GPCRs).
Price Range : 618.00 USD - 8000.00 USD
Receptor-expressing cell lines

Adenosine A2A AequoScreen; cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 (Eu) + Total ERK 545 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 + Total ERK assay kit is used to measure both the phosphorylation (Thr202/Tyr204) and total levels of endogenous “extracellular signal-regulated kinase 1 and 2” (ERK 1/2) in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure ERK 1/2 activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 855.00 USD - 49600.00 USD
SureFire principle

AlphaScreen SureFire p-Akt 1/2/3 (Thr308) research kit

The AlphaScreen® SureFire® p-Akt1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
Price Range : 1590.00 USD - 17200.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, CHO-K1

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 835.00 USD
PerkinElmer

Precise Analytical Services

PerkinElmer's experienced chemists will work with you, scientist to scientist, to design and prepare your radiochemical. You'll have access to PerkinElmer's extensive technical support resources, both during the specification process and after delivery, to ensure your custom product meets your exact specifications and application needs. We offer industry-leading turnaround times on quotations and deliveries worldwide-and highly competitive pricing.
PerkinElmer

Membrane Target Systems: Galanin Gal1 (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human galanin Gal1 receptor, 400 units.
List Price : 866.00 USD
Receptor-expressing cell lines

Adenosine A2B AequoScreen; cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
Receptor-expressing cell lines

AequoZen FroZen cells, Adenosine A1, Human Recombinant, CHO-K1

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 835.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ Multiplex p-ERK (Eu) (directly coupled) Kit, 10,000 Assay Points

Single target-only kit for multiplexing to other AlphaLISA SureFire Ultra assay kits. The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
List Price : 8800.00 USD
List Price : 2208.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-Akt 1/2/3 (S473) (Eu) + Total Akt1 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-Akt 1/2/3 (Ser473) + Total Akt 1 assay kit is used to measure both the phosphorylation (Ser473) and total levels of endogenous Akt in cellular lysates. The kit measures phosphorylation on Ser473 of Akt 1/2/3, and total levels of Akt 1 only. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure Akt (Ser473) activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 855.00 USD - 49600.00 USD

QRFP-43, [125I], Human Radioligand, 10µCi (370kBq)

QRFP-43 is a 43 amino acid polypeptide starting from N-terminal pyroglutamic acid and ending at C-terminal arginine-phenylalanine-amide. The intravenous administration of QRFP-43 caused the release of aldosterone, suggesting that QRFP and its receptor have a regulatory function in the rat adrenal gland.
List Price : 1162.00 USD
alphascreen surefire total

AlphaScreen SureFire Monoclonal Total ERK, 10,000 Assay Points

The AlphaScreen® SureFire® total ERK assay is a sandwich immunoassay for quantitative detection of ERK (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies. This assay performs similarly to the TGRTES SureFire kit, but contains a monoclonal antibody for ERK detection.
List Price : 7000.00 USD

N-succinimidyl-3-(4-hydroxy-3-[125I]iodophenyl)propionate, Bolton-Hunter Reagent, 1 mCi

Anhydrous benzene A charcoal trap is provided with each vial. Bolton-Hunter reagent. Radiochemical Purity is>95%.
List Price : 957.00 USD
PerkinElmer

Membrane Target Systems: Cannabinoid CB2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Cannabinoid CB2 receptor, in HEK-293 cells.
List Price : 891.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire Ultra Multiplex p-AKT(Ser473) (Eu) + p-ERK (Tb) Kit

The Alpha SureFire® Ultra Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
Price Range : 855.00 USD - 49600.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, CHO-K1 (+Gα16, medium level)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 835.00 USD
Receptor-expressing cell lines

Adenosine A1 AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
PerkinElmer

Membrane Target Systems: Chemoattractant C5a (human varient) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human chemoattractant C5a (human varient) receptor, 400 units.
List Price : 891.00 USD
PerkinElmer

Membrane Target Systems: Vasopressin V1a (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Vasopressin V1a receptor, in HEK-293 cells.
List Price : 891.00 USD
Receptor-expressing cell lines

cAMPZen Frozen cells, Adenosine A2B, Human Recombinant, HEK293

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 523.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, HEK293

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 835.00 USD
Receptor-expressing cell lines

cAMPZen Frozen cells, Adenosine A1, Human Recombinant, CHO-K1

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 526.00 USD
PerkinElmer

Membrane Target Systems: GABA B1a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human GABA B1a receptor, 400 units.
List Price : 891.00 USD

LANCE cAMP Detection Kit

LANCE® TR-FRET cAMP assay kit, for Gs- and Gi-coupled GPCR functional assays.
Price Range : 163.00 USD - 7200.00 USD
PerkinElmer

Membrane Target Systems: GABA B1b in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1b receptor, 400 units.
List Price : 891.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Adrenergic α2A, Human Recombinant, CHO-K1

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 835.00 USD
SureFire principle

AlphaScreen SureFire Akt 123 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt1/2/3 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
Price Range : 435.00 USD - 17200.00 USD
PerkinElmer

Membrane Target Systems: Serotonin 5HT1a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from cells stably-transfected with human serotonin 5HT1a receptor
List Price : 891.00 USD
PerkinElmer

Membrane Target Systems: Vasopressin V1b (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Vasopressin V1b receptor, in HEK-293 cells.
List Price : 891.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, 1321N1

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 835.00 USD
Receptor-expressing cell lines

Adenosine A3 AequoScreen® cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
PerkinElmer

Membrane Target Systems: Serotonin 5HT2c (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human serotonin 5HT2c receptor, 400 units.
List Price : 891.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, CHO-K1 (+Gα16)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 835.00 USD
Receptor-expressing cell lines

cAMPZen Frozen cells, Adrenergic α2A, Human Recombinant, CHO-K1

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 527.00 USD

2`-Deoxycytidine-5`-triphosphate, 5-[125I]iodo-, Tetraammonium Salt, 1 mCi (37 MBq),

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
List Price : 2612.00 USD
SureFire principle

AlphaScreen SureFire Akt 1/2 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt 1/2 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt 1/2 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
Price Range : 1449.00 USD - 15700.00 USD
Receptor-expressing cell lines

Adrenergic alpha 2B AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.

"GPCR" 1-50 of 120 Products and Services

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