PerkinElmer

GPCR

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Accelerate your research into G-protein-coupled receptors with integrated solutions for any GPCR target, including Gs-, Gq- and Gi-coupled receptors. Count on us to help you identify and monitor

  • Effects of GPCR pathway activation: intracellular calcium, cAMP, phospho-ERK, inositol phosphate
  • Reporter gene expression
  • Receptor ligand binding
  • GTP binding

Our state-of-the-art GPCR solutions portfolio is extensive and includes:

  • Scalable GPCR cellular imaging, detection instrumentation and liquid handling systems for radiometric fluorescence, luminescence or photometric detection
  • Optimized cell-based assay platforms
  • Versatile reagents—GPCR cell lines; frozen, ready-to-use cells; radioligands; ligands; cloned receptor membranes

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Product Type
  • Accessories (4)
  • Instruments (6)
  • Reagents (88)
Application
  • cAMP (8)
  • Drug Discovery & Development (38)
  • Kinase (6)
  • Multiplexing (5)
  • Protein Analysis & Detection (9)
Assay points(200-50,000)
  • 100 (8)
  • 1000 (1)
  • 10000 (14)
  • 500 (13)
  • 50000 (14)
Assay Target
  • Akt1 (2)
  • Akt1/2 (1)
  • Akt1/2/3 (6)
  • cAMP (3)
  • CREB (2)
  • ERK1/2 (6)
Assay Target Class
  • GPCR (46)
  • Phosphoprotein (15)
  • Protein (3)
Assay Validated
  • Binding (35)
  • Calcium Fluorescence (4)
  • Calcium Luminescence (20)
  • cAMP (5)
  • Downstream Phosphorylation (4)
Automation Compatible
  • Yes (22)
Concentration
  • 1.0 - 10 mCi/mL (2)
  • 1.12 mCi/mL (1)
  • 50 µCi/mL (1)
  • 83.8 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • <1.0 µCi/mL (1)
Detection Method
  • Absorbance (5)
  • Alpha (20)
  • Fluorescence (5)
  • Fluorescence Polarization (3)
  • Image-based Cytometry (1)
  • Label-free (2)
  • Luminescence (5)
  • Radiometric (9)
  • Time-Resolved Fluorescence (TRF) (7)
  • TR-FRET (2)
Experimental Type
  • In vitro (15)
Format
  • Microplates (18)
Host Cell
  • 1321N1 (2)
  • A9 (1)
  • CHO-K1 (27)
  • HEK293 (23)
  • HT29 (1)
  • L Cells (1)
  • U373 (1)
  • UC11 (1)
Label Position
  • Nominally Labeled (7)
  • Specifically Labeled (2)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)
Molecular Modification
  • Phosphorylation (11)
Product Brand Name
  • AequoScreen (6)
  • AequoZen (14)
  • Alpha SureFire Ultra Multiplex (5)
  • AlphaLISA SureFire Ultra (3)
  • AlphaPlex (5)
  • AlphaScreen (1)
  • AlphaScreen SureFire (8)
  • cAMPZen (5)
  • EnSight (1)
  • EnSpire (3)
  • EnVision (3)
  • LANCE (1)
  • LANCE Ultra (1)
  • Membrane Target Systems (32)
  • NEN Radiochemicals (2)
  • NEN Radiolabeled Ligands (7)
  • OnPoint (3)
  • Victor (1)
  • ViewLux (1)
Radionuclide
  • 125I (7)
  • 3H (2)
Radioisotope
  • H-3 (2)
  • I-125 (7)
Receptor Type
  • 5-Hydroxytryptamine (1)
  • 5-Hydroxytryptamine (Serotonin) (4)
  • Adenosine (13)
  • Adrenergic (5)
  • Anaphylatoxin (1)
  • Calcitonin (1)
  • Cannabinoid (1)
  • Dopamine (1)
  • GABA (4)
  • Galanin (1)
  • Glucagon (1)
  • Histamine (1)
  • Insulin (1)
  • Melanocortin (2)
  • Motilin (1)
  • Neurotensin (2)
  • Opioid (4)
  • Prostanoid (1)
  • Tachykinin (1)
  • Urotensin (1)
  • Vasoactive Intestinal Peptide (1)
  • Vasopressin (4)
Target Species
  • Human (11)
Therapeutic Area
  • Angiogenesis (1)
  • Cardiovascular (28)
  • Central Nervous System (33)
  • Diabetes (7)
  • Gastrointestinal (14)
  • Inflammation (32)
  • Metabolic (16)
  • Obesity (2)
  • Pain (13)
  • Renal (2)

"GPCR" 1-50 of 98 Products and Services

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EnSight multimode plate-reader

EnSight Multimode Plate Reader

The EnSight multimode plate reader combines labeled, label-free* & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.

*Label free detection module of EnSight Plate Reader is available outside the EU. Please contact your local representative for further details.

EnVision_Alone_Left_Angle

EnVision 2105 Multimode Plate Reader

The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

VictorX_ImageA_320px

VICTOR Multilabel Plate Reader

The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).

EnSpire Alpha Plate Reader

The EnSpire Alpha Plate Reader provides proven Alpha technology to your lab at an affordable price and from the Alpha detection leader.

EnSpire Plate Reader is available outside the EU. Please contact your local representative for further details.

EnSpire Multimode Plate Reader

EnSpire® Multimode Plate Reader is designed to meet the demands of multi-user research environments, providing high performance technology and flexibility for a range of applications without compromising sensitivity. Combine this with our expertise and portfolio of reagents, PerkinElmer offers an unrivaled solution to your application needs.

EnSpire Plate Reader is available outside the EU. Please contact your local representative for further details.

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.

The ViewLux uHTS microplate imager is available outside the EU. Please contact your local representative to discuss alternative products.

Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-Akt 1/2/3 (S473) (Eu) + Total Akt1 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-Akt 1/2/3 (Ser473) + Total Akt 1 assay kit is used to measure both the phosphorylation (Ser473) and total levels of endogenous Akt in cellular lysates. The kit measures phosphorylation on Ser473 of Akt 1/2/3, and total levels of Akt 1 only. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure Akt (Ser473) activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 880.00 USD - 51100.00 USD
Receptor-expressing cell lines

Adenosine A3 AequoScreen® cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
PerkinElmer

Membrane Target Systems: Vasoactive Intestinal Polypeptide VIP membrane preparation

Cell membranes prepared from HT29 cells containing human endogenous Vasoactive Intestinal Polypeptide (VIP) receptor.
List Price : 980.00 USD
SureFire principle

AlphaScreen SureFire Phospho-AKT (Thr308) Kit

The AlphaScreen® SureFire® p-Akt1 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
Price Range : 1493.00 USD - 16100.00 USD
PerkinElmer

Membrane Target Systems: Neurokinin NK1 (human endogenous) membrane preparation, in UC11 cells. 400 Units.

Cell membranes prepared from UC11 cells with human neurokinin NK1 receptor, 400 units.
List Price : 936.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire Ultra Multiplex p-ERK (Eu) (directly coupled) Kit

Single target-only kit for multiplexing to other AlphaLISA SureFire Ultra assay kits. The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
Price Range : 489.00 USD - 28400.00 USD
SureFire principle

Phospho-ERK (Thr202/Tyr204) Monoclonal AlphaScreen SureFire Assay kit

The AlphaScreen® SureFire® Monoclonal p-ERK1/2 (Thr202/Tyr204) assay is a sandwich immunoassay for quantitative detection of phospho-ERK1/2 (phosphorylated on Thr202/Tyr204) in cellular lysates using Alpha Technology. This assay performs similarly to the TGRES SureFire kit, but contains a monoclonal antibody for phospho-ERK detection.
Price Range : 492.00 USD - 17700.00 USD
SureFire principle

AlphaScreen SureFire Akt 123 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt1/2/3 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
Price Range : 492.00 USD - 17700.00 USD

SB-269970, [3H]

Tritiated SB-269970. SB-269970 is believed to act as a selective serotonin 5-HT7 antagonist, or possibly an inverse agonist.
List Price : 3261.00 USD
Receptor-expressing cell lines

cAMPZen Frozen cells, Adenosine A2B, Human Recombinant, HEK293

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 602.00 USD
SureFire principle

AlphaScreen SureFire Akt 1/2 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt 1/2 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt 1/2 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
Price Range : 1493.00 USD - 16100.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-ERK1/2 (Thr202/Tyr204) Assay Kit

The AlphaLISA® SureFire® Ultra p-ERK 1/2 (Thr202/Tyr204) assay is a sandwich immunoassay for quantitative detection of phospho-ERK 1/2 (phosphorylated on Thr202/Tyr204 in ERK1, or Thr185/Tyr187 in ERK2) in cellular lysates using Alpha Technology.
Price Range : 489.00 USD - 28400.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, HEK293 (+Gα16)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 961.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, CHO-K1

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 961.00 USD
SureFire principle

AlphaScreen SureFire p-Akt 1/2/3 (Thr308) research kit

The AlphaScreen® SureFire® p-Akt1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
Price Range : 1653.00 USD - 17700.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Adenosine A1, Human Recombinant, CHO-K1

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 961.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire Ultra Multiplex p-AKT (Ser473) (directly coupled) Kit

Single target-only kit for multiplexing to other AlphaLISA SureFire Ultra assay kits. The Alpha SureFire® Ultra Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
Price Range : 489.00 USD - 28400.00 USD
PerkinElmer

Membrane Target Systems: Vasopressin V1a (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Vasopressin V1a receptor, in HEK-293 cells.
List Price : 936.00 USD
AlphaScreen cAMP assay principle

AlphaScreen cAMP Detection Kit

AlphaScreen no-wash assay kit for quantitative detection of cAMP.
Price Range : 403.00 USD - 13800.00 USD
PerkinElmer

Membrane Target Systems: Adenosine A1 (rat) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with rat adenosine A1 receptor, 400 units.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: GABA B1a in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1a receptor, 400 units.
List Price : 936.00 USD
Receptor-expressing cell lines

cAMPZen Frozen cells, Adenosine A3, Human Recombinant, CHO-K1

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 582.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-AKT1/2/3 (Thr308) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-AKT1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-AKT1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
Price Range : 489.00 USD - 28400.00 USD

LANCE cAMP Detection Kit

LANCE® TR-FRET cAMP assay kit, for Gs- and Gi-coupled GPCR functional assays.
Price Range : 167.00 USD - 7400.00 USD

GLP-1 (7-36), [125I]

Glucagon-like peptide-1 (GLP-1), labeled with 125I. GLP-1 is a peptide hormone involved in secretion of insulin, and binds and activates GLP-1 receptors, a member of the glucagon receptor family of GPCRs.
Price Range : 1219.00 USD - 2224.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-CREB (Ser133) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
Price Range : 489.00 USD - 28400.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 (Eu) + Total ERK 545 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 + Total ERK assay kit is used to measure both the phosphorylation (Thr202/Tyr204) and total levels of endogenous “extracellular signal-regulated kinase 1 and 2” (ERK 1/2) in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure ERK 1/2 activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 880.00 USD - 51100.00 USD
SureFire principle

AlphaScreen SureFire CREB (p-Ser133) Assay Kit

The AlphaScreen® SureFire® p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
Price Range : 1653.00 USD - 17700.00 USD
SureFire principle

AlphaScreen SureFire Akt 1 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt1 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
Price Range : 1493.00 USD - 16100.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, HEK293

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 961.00 USD
PerkinElmer

Membrane Target Systems: Adenosine A3 (rat) membrane preparation

Cell membranes prepared from cells stably-transfected with rat Adenosine A3 receptor, in HEK-293 cells.
List Price : 936.00 USD

(+)-Pentazocine, [Ring-1,3-3H]

(+)-Pentazocine radioligand tritiated at the 1,3 position on the ring. Pentazocine is a synthetic opioid shown to bind sigma 1 receptor.
Price Range : 621.00 USD - 4846.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Parental, CHO-K1 (+Gα16)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 961.00 USD
PerkinElmer

Membrane Target Systems: Nociceptin NOP (ORL1) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human Nociceptin NOP (ORL1) receptor, 400 units.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: GABA B1b (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human GABA B1b receptor, 400 units.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Urotensin UR2 (GPR14) (mouse) membrane preparation

Cell membranes prepared from cells stably-transfected with human Urotensin UR2 (GPR14) receptor, in CHO-K1 cells.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Melanocortin MC3 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Melanocortin MC3 receptor, in HEK-293 cells.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Cannabinoid CB2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Cannabinoid CB2 receptor, in HEK-293 cells.
List Price : 936.00 USD

Motilin, [125I]

Motilin, labeled with 125I. Motilin is a peptide hormone that binds motilin receptors, and stimulates contraction of gut smooth muscle.
Price Range : 1153.00 USD - 2319.00 USD
PerkinElmer

Membrane Target Systems: Serotonin 5HT2c (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human serotonin 5HT2c receptor, 400 units.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Opioid Delta (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human opioid delta receptor, 400 units.
List Price : 936.00 USD

N-succinimidyl-3-(4-hydroxy-3-[125I]iodophenyl)propionate, Bolton-Hunter Reagent

Bolton-Hunter reagent, monoiodinated. This product is used to iodinate proteins that do not contain tyrosine residues. Bolton-Hunter reagent is the N-hydroxysuccinimide ester of iodinated p-hydroxyphenylpropionic acid. The active ester acylates terminal amino groups with the iodinated p-hydxyphenylpropionic residue, effectively introducing radioactive iodine into proteins and peptides. A non-oxidative technique, it is less harsh to proteins than alternative labeling methods. An anhydrous benzene A charcoal trap is provided with each vial.
Price Range : 582.00 USD - 1589.00 USD
PerkinElmer

Membrane Target Systems: Galanin Gal1 (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human galanin Gal1 receptor, 400 units.
List Price : 909.00 USD
PerkinElmer

Membrane Target Systems: Neurotensin NTS1 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Neurotensin NTS1 receptor, in HEK-293 cells.
List Price : 936.00 USD

"GPCR" 1-50 of 98 Products and Services