GPCR

OF

Accelerate your research into G-protein-coupled receptors with integrated solutions for any GPCR target, including Gs-, Gq- and Gi-coupled receptors. Count on us to help you identify and monitor

  • Effects of GPCR pathway activation: intracellular calcium, cAMP, phospho-ERK, inositol phosphate
  • Reporter gene expression
  • Receptor ligand binding
  • GTP binding

Our state-of-the-art GPCR solutions portfolio is extensive and includes:

  • Scalable GPCR cellular imaging, detection instrumentation and liquid handling systems for radiometric fluorescence, luminescence or photometric detection
  • Optimized cell-based assay platforms
  • Versatile reagents—GPCR cell lines; frozen, ready-to-use cells; radioligands; ligands; cloned receptor membranes

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Product Type
  • Accessories (7)
  • Instruments (6)
  • Reagents (136)
Application
  • cAMP (8)
  • Drug Discovery & Development (49)
  • Kinase (13)
  • Multiplexing (14)
  • Protein Analysis & Detection (25)
Assay Points
  • 100 (8)
  • 1000 (1)
  • 10000 (14)
  • 500 (13)
  • 50000 (13)
Assay Target
  • Akt1 (4)
  • Akt1/2 (2)
  • Akt1/2/3 (17)
  • cAMP (3)
  • CREB (7)
  • ERK1/2 (21)
Assay Target Class
  • GPCR (46)
  • Phosphoprotein (43)
  • Protein (6)
Assay Validated
  • Binding (35)
  • Calcium Fluorescence (4)
  • Calcium Luminescence (20)
  • cAMP (5)
  • Downstream Phosphorylation (4)
Automation Compatible
  • Yes (53)
Concentration
  • 1.0 - 10 mCi/mL (2)
  • 1.12 mCi/mL (2)
  • 171.9 µCi/mL (2)
  • 50 µCi/mL (1)
  • 83.8 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • <1.0 µCi/mL (1)
Detection Method
  • Absorbance (5)
  • Alpha (51)
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  • Image-based Cytometry (1)
  • Label-free (2)
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  • Radiometric (26)
  • Time-Resolved Fluorescence (TRF) (7)
  • TR-FRET (2)
Experimental type
  • In vitro (37)
Format
  • Microplates (49)
Host Cell
  • 1321N1 (2)
  • A9 (1)
  • CHO-K1 (27)
  • HEK293 (23)
  • HT29 (1)
  • L Cells (1)
  • U373 (1)
  • UC11 (1)
Label Position
  • Generally Labeled (1)
  • Nominally Labeled (19)
  • Specifically Labeled (6)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)
Molecular modification
  • Phosphorylation (27)
Product Brand Name
  • AequoScreen (6)
  • AequoZen (14)
  • Alpha SureFire Ultra Multiplex (14)
  • AlphaLISA SureFire Ultra (12)
  • AlphaPlex (14)
  • AlphaScreen (1)
  • AlphaScreen SureFire (21)
  • cAMPZen (5)
  • EnSight (1)
  • EnSpire (3)
  • EnVision (3)
  • LANCE (1)
  • LANCE Ultra (1)
  • Membrane Target Systems (32)
  • NEN Radiochemicals (7)
  • NEN Radiolabeled Ligands (18)
  • OnPoint (3)
  • Victor (4)
  • ViewLux (1)
Radionuclide
  • 125I (19)
  • 3H (7)
Radioisotope
  • H-3 (7)
  • I-125 (19)
Receptor Type
  • 5-Hydroxytryptamine (1)
  • 5-Hydroxytryptamine (Serotonin) (4)
  • Adenosine (13)
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  • Anaphylatoxin (1)
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  • Prostanoid (1)
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  • Vasoactive Intestinal Peptide (1)
  • Vasopressin (4)
Target Species
  • Human (27)
Therapeutic Area
  • Angiogenesis (1)
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  • Pain (15)
  • Renal (2)
Volume
  • 0-50 (66)
  • 51-100 (2)
  • 201-250 (4)
  • 351-400 (30)
  • 451-500 (6)
  • Over 500 (5)

"GPCR" 1-50 of 149 Products and Services

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ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.
EnVision_Alone_Left_Angle

EnVision Multilabel Reader

The EnVision Multilabel Plate Reader provides the highest speed, ultra-high throughput, and maximum sensitivity across  all detection technologies, so that your high throughput screening applications won’t be held back by unreliable results or equipment that can’t keep up to the demands of escalating workloads and new assays.

EnSpire Multimode Plate Reader

EnSpire® Multimode Plate Reader is designed to meet the demands of multi-user research environments, providing high performance technology and flexibility for a range of applications without compromising sensitivity. Combine this with our expertise and portfolio of reagents, PerkinElmer offers an unrivaled solution to your application needs.

EnSight Multimode Plate Reader

The EnSight Multimode Plate Reader is the first benchtop system to offer well-imaging alongside label-free and labeled detection technologies.
VictorX_ImageA_320px

VICTOR Multilabel Plate Reader

The next generation VICTOR X Multilabel Plate Reader platform delivers flexibility, speed and performance to research labs of all sizes.

EnSpire Alpha Plate Reader

The EnSpire Alpha Plate Reader provides proven Alpha technology to your lab at an affordable price and from the Alpha detection leader.
SureFire principle

AlphaScreen SureFire p-Akt 1/2/3 (Thr308) research kit, 50,000 points

The AlphaScreen® SureFire® p-Akt1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
List Price : 16700.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ Multiplex p-AKT(Ser473) (Eu) + p-ERK (Tb) Kit, 500 Assay Points

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
List Price : 2805.00 USD
SureFire principle

AlphaScreen SureFire p-Akt 1/2/3 (Thr308) research kit, 500 points

The AlphaScreen® SureFire® p-Akt1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
List Price : 1543.00 USD

Membrane Target Systems: Chemoattractant C5a (human varient) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human chemoattractant C5a (human varient) receptor, 400 units.
List Price : 849.00 USD

2`-Deoxycytidine-5`-triphosphate, 5-[125I]iodo-, Tetraammonium Salt, 100µCi (3.7MBq)

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
List Price : 949.00 USD

Insulin (human, recombinant), [125I], 50 µCi

[125I]-Insulin (h) is suitable for the use in radioimmunoassay as well as receptor binding assay. [125I]-Insulin (h) is radioiodinated with no carrier added 125I using the LPO iodination procedure and is purified by reversed phase HPLC.
List Price : 1829.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-CREB (Ser133) Assay Kit - 50,000 Assay Points

The AlphaLISA® SureFire® Ultra™ p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
List Price : 26700.00 USD

Adenosine A3 AequoScreen® cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.

Eledoisin, [125I]- Lys4-, Bolton-Hunter Labeled, 10µCi

This product will be discontinued from our catalog portfolio on January 1, 2017 and will move to our custom iodination portfolio at that time.
List Price : 1552.00 USD

Membrane Target Systems: Serotonin 5HT6 (rat) membrane preparation

Cell membranes prepared from cells stably-transfected with rat Serotonin 5-HT6 receptor, in HEK-293 cells.
List Price : 849.00 USD

(+)-Pentazocine, [Ring-1,3-3H]-, 25µCi (925kBq)

25 µCi quantities of [Ring-1, 3-3H]-(+)-Pentazocine are available for your research.
List Price : 514.00 USD

cAMPZen Frozen cells, Adenosine A2B, Human Recombinant, HEK293

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 476.00 USD
SureFire principle

AlphaScreen SureFire Monoclonal ERK p-T202/Y204 HV, 100 Assay Points

The AlphaScreen® SureFire® Monoclonal p-ERK1/2 (Thr202/Tyr204) assay is a sandwich immunoassay for quantitative detection of phospho-ERK1/2 (phosphorylated on Thr202/Tyr204) in cellular lysates using Alpha Technology. This assay performs similarly to the TGRES SureFire kit, but contains a monoclonal antibody for phospho-ERK detection.
List Price : 422.00 USD
SureFire principle

AlphaScreen SureFire Akt 123 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt1/2/3 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
Price Range : 422.00 USD - 16700.00 USD

GLP-1 (7-36), [125I]-, 50µCi (1.85MBq)

NEX308 Glucagon-like peptide-1 (GLP-1) is derived from the transcription product of the proglucagon gene. The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a gut hormone. The biologically active forms of GLP-1 are: GLP-1-(7-37) and GLP-1-(7-36)NH2.
List Price : 1926.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ Multiplex p-AKT(Ser473) (Eu) + p-ERK (Tb) HV Kit, 100 Assay Points

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
List Price : 830.00 USD

AequoZen frozen cells Starter Kit

AequoZen cells expressing the histamine H1 or the muscarinic M5 receptor for flash-luminescence assay.
List Price : 1403.00 USD

LANCE Ultra cAMP kit

The LANCE® Ultra cAMP assay is a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay designed to measure cAMP produced upon modulation of adenylyl cyclase activity by G-protein coupled receptors (GPCRs).
Price Range : 600.00 USD - 7800.00 USD
List Price : 2008.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-CREB (Ser133) Assay Kit - High Volume

The AlphaLISA® SureFire® Ultra™ p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
List Price : 461.00 USD
SureFire principle

AlphaScreen SureFire Akt 1/2 (p-Ser473) Assay Kit - 10,000 Points

The AlphaScreen® SureFire® p-Akt 1/2 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt 1/2 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
List Price : 6200.00 USD

Membrane Target Systems: A9 cells membranes

Wild Type Subtype A9L (mouse) Control Membrane 10mg Frozen suspension cell membrane. Shipped on dry ice.
List Price : 505.00 USD

(+)-Pentazocine, [Ring-1,3-3H]-,250µCi (9.25MBq)

250 µCi quantities of [Ring-1, 3-3H]-(+)-Pentazocine are available for your research.
List Price : 1675.00 USD

Adenosine A2B AequoScreen; cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
alphascreen surefire total

AlphaScreen SureFire Monoclonal Total ERK, 500 Assay Points

The AlphaScreen® SureFire® total ERK assay is a sandwich immunoassay for quantitative detection of ERK (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies. This assay performs similarly to the TGRTES SureFire kit, but contains a monoclonal antibody for ERK detection.
List Price : 1543.00 USD

LANCE cAMP assay kit

LANCE® TR-FRET cAMP assay kit, for Gs- and Gi-coupled GPCR functional assays.
Price Range : 158.00 USD - 7000.00 USD

Membrane Target Systems: U-373 cell membranes

Wild Type Subtype U-373 (human) Control Membrane Frozen suspension cell membrane. Shipped on dry ice.
List Price : 505.00 USD
SureFire principle

AlphaScreen SureFire p-Akt 1/2/3 (Thr308) research kit, 10,000 points

The AlphaScreen® SureFire® p-Akt1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
List Price : 6800.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ Multiplex p-ERK (Eu) (directly coupled) HV Kit, 100 Assay Points

Single target-only kit for multiplexing to other AlphaLISA SureFire Ultra assay kits. The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
List Price : 461.00 USD

AequoZen FroZen cells, Parental, CHO-K1 (+Gαq/i5)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 759.00 USD

cAMPZen Frozen cells, Adenosine A3, Human Recombinant, CHO-K1

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 460.00 USD

Precise Analytical Services

PerkinElmer's experienced chemists will work with you, scientist to scientist, to design and prepare your radiochemical. You'll have access to PerkinElmer's extensive technical support resources, both during the specification process and after delivery, to ensure your custom product meets your exact specifications and application needs. We offer industry-leading turnaround times on quotations and deliveries worldwide-and highly competitive pricing.
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-Akt 1/2/3 (S473) (Eu) + Total Akt1 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-Akt 1/2/3 (Ser473) + Total Akt 1 assay kit is used to measure both the phosphorylation (Ser473) and total levels of endogenous Akt in cellular lysates. The kit measures phosphorylation on Ser473 of Akt 1/2/3, and total levels of Akt 1 only. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure Akt (Ser473) activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 830.00 USD - 48200.00 USD
SureFire principle

AlphaScreen SureFire Phospho-AKT (Thr308) Kit

The AlphaScreen® SureFire® p-Akt1 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
Price Range : 1407.00 USD - 15200.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-CREB (Ser133) Assay Kit - 500 Assay Points

The AlphaLISA® SureFire® Ultra™ p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
List Price : 1558.00 USD
alphascreen surefire total

AlphaScreen SureFire Monoclonal Total ERK HV, 100 Assay Points

The AlphaScreen® SureFire® total ERK assay is a sandwich immunoassay for quantitative detection of ERK (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies. This assay performs similarly to the TGRTES SureFire kit, but contains a monoclonal antibody for ERK detection.
List Price : 422.00 USD

AequoZen FroZen cells, Parental, 1321N1 (+Gα16)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 759.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-CREB (Ser133) Assay Kit - 10,000 Assay Points

The AlphaLISA® SureFire® Ultra™ p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
List Price : 8600.00 USD

Membrane Target Systems: Dopamine D1 (human) membrane preparation, in L cells cells. 400 Units.

Cell membranes prepared from L cells stably-transfected with human dopamine D1 receptor, 400 units.
List Price : 849.00 USD
SureFire principle

AlphaScreen SureFire Monoclonal ERK p-T202/Y204, 500 Assay Points

The AlphaScreen® SureFire® Monoclonal p-ERK1/2 (Thr202/Tyr204) assay is a sandwich immunoassay for quantitative detection of phospho-ERK1/2 (phosphorylated on Thr202/Tyr204) in cellular lysates using Alpha Technology. This assay performs similarly to the TGRES SureFire kit, but contains a monoclonal antibody for phospho-ERK detection.
List Price : 1543.00 USD

Membrane Target Systems: Serotonin 5HT2c (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human serotonin 5HT2c receptor, 400 units.
List Price : 849.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ Multiplex p-AKT(Ser473) (Eu) + p-ERK (Tb) Kit, 50,000 Assay Points

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
List Price : 48200.00 USD

125I and 131I Radioiodination Services

PerkinElmer's experienced chemists will work with you, scientist to scientist, to design and prepare your radiochemical. You'll have access to PerkinElmer's extensive technical support resources, both during the specification process and after delivery, to ensure your custom product meets your exact specifications and application needs. We offer industry-leading turnaround times on quotations and deliveries worldwide-and highly competitive pricing.

AequoZen FroZen cells, Parental, HEK293

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 759.00 USD

"GPCR" 1-50 of 149 Products and Services

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