GPCR

OF

Accelerate your research into G-protein-coupled receptors with integrated solutions for any GPCR target, including Gs-, Gq- and Gi-coupled receptors. Count on us to help you identify and monitor

  • Effects of GPCR pathway activation: intracellular calcium, cAMP, phospho-ERK, inositol phosphate
  • Reporter gene expression
  • Receptor ligand binding
  • GTP binding

Our state-of-the-art GPCR solutions portfolio is extensive and includes:

  • Scalable GPCR cellular imaging, detection instrumentation and liquid handling systems for radiometric fluorescence, luminescence or photometric detection
  • Optimized cell-based assay platforms
  • Versatile reagents—GPCR cell lines; frozen, ready-to-use cells; radioligands; ligands; cloned receptor membranes

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Product Type
  • Accessories (7)
  • Instruments (6)
  • Reagents (136)
Application
  • cAMP (8)
  • Drug Discovery & Development (49)
  • Kinase (13)
  • Multiplexing (14)
  • Protein Analysis & Detection (25)
Assay Points
  • 100 (8)
  • 1000 (1)
  • 10000 (14)
  • 500 (13)
  • 50000 (13)
Assay Target
  • Akt1 (4)
  • Akt1/2 (2)
  • Akt1/2/3 (17)
  • cAMP (3)
  • CREB (7)
  • ERK1/2 (21)
Assay Target Class
  • GPCR (46)
  • Phosphoprotein (43)
  • Protein (6)
Assay Validated
  • Binding (35)
  • Calcium Fluorescence (4)
  • Calcium Luminescence (20)
  • cAMP (5)
  • Downstream Phosphorylation (4)
Automation Compatible
  • Yes (53)
Concentration
  • 1.0 - 10 mCi/mL (2)
  • 1.12 mCi/mL (2)
  • 171.9 µCi/mL (2)
  • 50 µCi/mL (1)
  • 83.8 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • <1.0 µCi/mL (1)
Detection Method
  • Absorbance (5)
  • Alpha (51)
  • Fluorescence (5)
  • Fluorescence Polarization (3)
  • Image-based Cytometry (1)
  • Label-free (2)
  • Luminescence (5)
  • Radiometric (26)
  • Time-Resolved Fluorescence (TRF) (7)
  • TR-FRET (2)
Experimental type
  • In vitro (37)
Format
  • Microplates (49)
Host Cell
  • 1321N1 (2)
  • A9 (1)
  • CHO-K1 (27)
  • HEK293 (23)
  • HT29 (1)
  • L Cells (1)
  • U373 (1)
  • UC11 (1)
Label Position
  • Generally Labeled (1)
  • Nominally Labeled (19)
  • Specifically Labeled (6)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)
Molecular modification
  • Phosphorylation (27)
Product Brand Name
  • AequoScreen (6)
  • AequoZen (14)
  • Alpha SureFire Ultra Multiplex (14)
  • AlphaLISA SureFire Ultra (12)
  • AlphaPlex (14)
  • AlphaScreen (1)
  • AlphaScreen SureFire (21)
  • cAMPZen (5)
  • EnSight (1)
  • EnSpire (3)
  • EnVision (3)
  • LANCE (1)
  • LANCE Ultra (1)
  • Membrane Target Systems (32)
  • NEN Radiochemicals (7)
  • NEN Radiolabeled Ligands (18)
  • OnPoint (3)
  • Victor (4)
  • ViewLux (1)
Radionuclide
  • 125I (19)
  • 3H (7)
Radioisotope
  • H-3 (7)
  • I-125 (19)
Receptor Type
  • 5-Hydroxytryptamine (1)
  • 5-Hydroxytryptamine (Serotonin) (4)
  • Adenosine (13)
  • Adrenergic (5)
  • Anaphylatoxin (1)
  • Calcitonin (2)
  • Cannabinoid (1)
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  • GABA (4)
  • Galanin (1)
  • Glucagon (2)
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  • Insulin (2)
  • Melanocortin (2)
  • Motilin (2)
  • Neurotensin (2)
  • Opioid (6)
  • Peptide P518 (2)
  • Prostanoid (1)
  • Tachykinin (1)
  • Urotensin (1)
  • Vasoactive Intestinal Peptide (1)
  • Vasopressin (4)
Target Species
  • Human (27)
Therapeutic Area
  • Angiogenesis (1)
  • Cardiovascular (28)
  • Central Nervous System (33)
  • Diabetes (9)
  • Gastrointestinal (17)
  • Inflammation (32)
  • Metabolic (16)
  • Obesity (5)
  • Pain (15)
  • Renal (2)
Volume
  • 0-50 (66)
  • 51-100 (2)
  • 201-250 (4)
  • 351-400 (30)
  • 451-500 (6)
  • Over 500 (5)

"GPCR" 1-50 of 149 Products and Services

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VictorX_ImageA_320px

VICTOR Multilabel Plate Reader

The next generation VICTOR X Multilabel Plate Reader platform delivers flexibility, speed and performance to research labs of all sizes.

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.
EnVision_Alone_Left_Angle

EnVision Multilabel Reader

The EnVision Multilabel Plate Reader provides the highest speed, ultra-high throughput, and maximum sensitivity across  all detection technologies, so that your high throughput screening applications won’t be held back by unreliable results or equipment that can’t keep up to the demands of escalating workloads and new assays.

EnSpire Alpha Plate Reader

The EnSpire Alpha Plate Reader provides proven Alpha technology to your lab at an affordable price and from the Alpha detection leader.

EnSpire Multimode Plate Reader

EnSpire® Multimode Plate Reader is designed to meet the demands of multi-user research environments, providing high performance technology and flexibility for a range of applications without compromising sensitivity. Combine this with our expertise and portfolio of reagents, PerkinElmer offers an unrivaled solution to your application needs.

EnSight Multimode Plate Reader

The EnSight Multimode Plate Reader is the first benchtop system to offer well-imaging alongside label-free and labeled detection technologies.
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-CREB (Ser133) Assay Kit - 10,000 Assay Points

The AlphaLISA® SureFire® Ultra™ p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
List Price : 8600.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-CREB (Ser133) Assay Kit - 500 Assay Points

The AlphaLISA® SureFire® Ultra™ p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
List Price : 1558.00 USD

Adenosine A3, Human Recombinant, CHO-K1 AequoZen® Frozen cells

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 760.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-CREB (Ser133) Assay Kit - 50,000 Assay Points

The AlphaLISA® SureFire® Ultra™ p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
List Price : 26700.00 USD
alphascreen surefire total

AlphaScreen SureFire Monoclonal Total ERK HV, 100 Assay Points

The AlphaScreen® SureFire® total ERK assay is a sandwich immunoassay for quantitative detection of ERK (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies. This assay performs similarly to the TGRTES SureFire kit, but contains a monoclonal antibody for ERK detection.
List Price : 422.00 USD

14C, 3H and 35S Custom Synthesis

PerkinElmer's experienced chemists will work with you, scientist to scientist, to design and prepare your radiochemical. You'll have access to PerkinElmer's extensive technical support resources, both during the specification process and after delivery, to ensure your custom product meets your exact specifications and application needs. We offer industry-leading turnaround times on quotations and deliveries worldwide-and highly competitive pricing.
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-CREB (Ser133) Assay Kit - High Volume

The AlphaLISA® SureFire® Ultra™ p-CREB (Ser133) assay is a sandwich immunoassay for quantitative detection of phospho-CREB (phosphorylated on Ser133) in cellular lysates using Alpha Technology.
List Price : 461.00 USD

IL-8 (human, recombinant), I-125, Receptor Grade, 10 µCi

This product will be discontinued from our catalog portfolio on January 1, 2017 and will move to our custom iodination portfolio at that time.
List Price : 1245.00 USD
alphascreen surefire total

AlphaScreen SureFire Monoclonal Total ERK, 50,000 Assay Points

The AlphaScreen® SureFire® total ERK assay is a sandwich immunoassay for quantitative detection of ERK (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies. This assay performs similarly to the TGRTES SureFire kit, but contains a monoclonal antibody for ERK detection.
List Price : 16700.00 USD

Membrane Target Systems: Neurotensin NTS1 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Neurotensin NTS1 receptor, in HEK-293 cells.
List Price : 849.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ Multiplex p-AKT(Ser473) (Eu) + p-ERK (Tb) Kit, 10,000 Assay Points

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
List Price : 15400.00 USD
SureFire principle

AlphaScreen SureFire Akt 123 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt1/2/3 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
Price Range : 422.00 USD - 16700.00 USD

Membrane Target Systems: Histamine H2 (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human Histamine H2 receptor, 400 units.
List Price : 849.00 USD

Precise Analytical Services

PerkinElmer's experienced chemists will work with you, scientist to scientist, to design and prepare your radiochemical. You'll have access to PerkinElmer's extensive technical support resources, both during the specification process and after delivery, to ensure your custom product meets your exact specifications and application needs. We offer industry-leading turnaround times on quotations and deliveries worldwide-and highly competitive pricing.

AequoZen FroZen cells, Parental, HEK293 (+Gα16)

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 759.00 USD

Membrane Target Systems: Melanocortin MC5 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Melanocortin MC5 receptor, in HEK-293 cells.
List Price : 849.00 USD

Membrane Target Systems: Serotonin 5HT6 (rat) membrane preparation

Cell membranes prepared from cells stably-transfected with rat Serotonin 5-HT6 receptor, in HEK-293 cells.
List Price : 849.00 USD

Membrane Target Systems: U-373 cell membranes

Wild Type Subtype U-373 (human) Control Membrane Frozen suspension cell membrane. Shipped on dry ice.
List Price : 505.00 USD

Membrane Target Systems: Vasopressin V1b (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human Vasopressin V1b receptor, 400 units.
List Price : 849.00 USD

AequoZen FroZen cells, Parental, 1321N1

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 759.00 USD

Adrenergic alpha 2B AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
List Price : 999.00 USD
alphascreen surefire total

AlphaScreen SureFire Monoclonal Total ERK, 500 Assay Points

The AlphaScreen® SureFire® total ERK assay is a sandwich immunoassay for quantitative detection of ERK (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization for phosphorylation studies. This assay performs similarly to the TGRTES SureFire kit, but contains a monoclonal antibody for ERK detection.
List Price : 1543.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ Multiplex p-AKT(Ser473) (Eu) + p-ERK (Tb) Kit, 500 Assay Points

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
List Price : 2805.00 USD

LANCE cAMP assay kit

LANCE® TR-FRET cAMP assay kit, for Gs- and Gi-coupled GPCR functional assays.
Price Range : 158.00 USD - 7000.00 USD

AequoZen FroZen cells, Parental, HEK293

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 759.00 USD

(+)-Pentazocine, [Ring-1,3-3H]-,250µCi (9.25MBq)

250 µCi quantities of [Ring-1, 3-3H]-(+)-Pentazocine are available for your research.
List Price : 1675.00 USD

AequoZen FroZen cells, Parental, CHO-K1

AequoScreen Parental cell stably expressing the mitochondrially targeted apoaequorin gene. GPCRs of your choice can be transiently or stably transfected into these cell lines, for luminescence calcium assays.
List Price : 759.00 USD

(+)-Pentazocine, [Ring-1,3-3H]-, 25µCi (925kBq)

25 µCi quantities of [Ring-1, 3-3H]-(+)-Pentazocine are available for your research.
List Price : 514.00 USD
SureFire principle

AlphaScreen SureFire p-Akt 1/2/3 (Thr308) research kit, 10,000 points

The AlphaScreen® SureFire® p-Akt1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
List Price : 6800.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-AKT1/2/3 (Thr308) Assay Kit - High Volume

The AlphaLISA® SureFire® Ultra™ p-AKT1/2/3 (Thr308) assay is a sandwich immunoassay for quantitative detection of phospho-AKT1/2/3 (phosphorylated on Thr308) in cellular lysates using Alpha Technology.
List Price : 461.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ Multiplex p-AKT (Ser473) (directly coupled) Kit, 10,000 Assay Points

Single target-only kit for multiplexing to other AlphaLISA SureFire Ultra assay kits. The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
List Price : 8500.00 USD

CGRP (human), [125I]-, 10µCi

NEX354 Human CGRP binds to human CGRP receptors in the central nervous system and peripheral nervous system. [125I]-CGRP (human) will be useful in the characterization of CGRP receptors.
List Price : 690.00 USD

AequoZen Frozen cells, Adenosine α2A, Human Recombinant, HEK293

Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 759.00 USD
SureFire principle

AlphaScreen SureFire Akt 1 (p-Ser473) Assay Kit - 500 Points

The AlphaScreen® SureFire® p-Akt1 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt1 (phosphorylated on Ser473) in cellular lysates using Alpha Technology.
List Price : 1407.00 USD

CGRP (human), [125I]-, 50µCi

NEX354 Human CGRP binds to human CGRP receptors in the central nervous system and peripheral nervous system. [125I]-CGRP (human) will be useful in the characterization of CGRP receptors.
List Price : 1672.00 USD

LANCE Ultra cAMP kit

The LANCE® Ultra cAMP assay is a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay designed to measure cAMP produced upon modulation of adenylyl cyclase activity by G-protein coupled receptors (GPCRs).
Price Range : 600.00 USD - 7800.00 USD
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 (Eu) + Total ERK 545 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-ERK 1/2 + Total ERK assay kit is used to measure both the phosphorylation (Thr202/Tyr204) and total levels of endogenous “extracellular signal-regulated kinase 1 and 2” (ERK 1/2) in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure ERK 1/2 activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 830.00 USD - 48200.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-ERK1/2 (Thr202/Tyr204) Assay Kit - High Volume

The AlphaLISA® SureFire® Ultra™ p-ERK 1/2 (Thr202/Tyr204) assay is a sandwich immunoassay for quantitative detection of phospho-ERK 1/2 (phosphorylated on Thr202/Tyr204 in ERK1, or Thr185/Tyr187 in ERK2) in cellular lysates using Alpha Technology.
List Price : 461.00 USD

Adrenergic alpha 2A AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ Multiplex p-ERK (Eu) (directly coupled) Kit, 10,000 Assay Points

Single target-only kit for multiplexing to other AlphaLISA SureFire Ultra assay kits. The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of phosphoproteins from cells, combined with the measurement of another protein, phospho or total. This Alpha Multiplex measurement is carried out in the same assay plate well from a single sample of cell lysate, and is achieved by the use of two types of Alpha Acceptor beads that emit at distinct wavelengths (545nm and 615nm).
List Price : 8500.00 USD

Membrane Target Systems: Urotensin UR2 (GPR14) (mouse) membrane preparation

Cell membranes prepared from cells stably-transfected with human Urotensin UR2 (GPR14) receptor, in CHO-K1 cells.
List Price : 849.00 USD

cAMPZen Frozen cells, Adrenergic α2A, Human Recombinant, CHO-K1

Our frozen, irradiated cAMPZen cells express a variety of GPCRs for binding and functional assays. No cell culture is required prior to testing.
List Price : 479.00 USD

QRFP-43, [125I], Human Radioligand, 25µCi (925kBq)

QRFP-43 is a 43 amino acid polypeptide starting from N-terminal pyroglutamic acid and ending at C-terminal arginine-phenylalanine-amide. The intravenous administration of QRFP-43 caused the release of aldosterone, suggesting that QRFP and its receptor have a regulatory function in the rat adrenal gland.
List Price : 2252.00 USD

"GPCR" 1-50 of 149 Products and Services

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