PerkinElmer

Fluorescent Agents

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Our portfolio of Targeted, Activatable, and Vascular fluorescent agents for imaging utilizes optimized in vivo chemistries and diverse mechanisms of action to deliver breakthrough imaging data on biological targets, pathways and processes - in the context of the living system.

 

Benefits of PerkinElmer Fluorescent Agents:

  • Biological, functional and physiological information
  • Easily applied to standard animal models
  • Versatile
    • use for simultaneous monitoring of multiple molecular processes
    • custom-design a fluorescent agent using PerkinElmer tags and/or nanoparticles
  • Designed and optimized for translational in vivo imaging narrow spectrally-separated excitation/emission spectra in the NIR region
  • High fluorescence efficiency (quantum yield)
  • Biocompatible, biodegradable and excretable
  • Chemical and photo-stability in vivo
  • Compatible with a variety of in vivo imaging systems
  • Developed and optimized on PerkinElmer's optical imaging platforms

 

 

For research use only. Not for use in diagnostic procedures.

 

Business Insights (4)
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  • Application Note

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • Application Note

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • Application Note

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • Poster

    Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

    Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more important to integrate safety/toxicology assessments earlier in the drug development process. There are a variety of traditional serum markers, tailored mechanistically to specific tissues, however there are no current non-invasive assessment tools that are capable of looking broadly at in situ biological changes in target and non-target tissue induced by chemical insult.

Products & Services (40)
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Therapeutic Area
  • Angiogenesis (9)
  • Arthritis (18)
  • Atherosclerosis (16)
  • Bacterial infection (4)
  • Inflammation (16)
  • Oncology/Cancer (25)
  • Vascular disease (4)
Product Brand Name
  • BacteriSense (1)
  • BombesinRSense (1)
  • Cat B FAST (2)
  • Cat K FAST (1)
  • FolateRSense (1)
  • GastroSense (1)
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  • GFR-Vivo (1)
  • HypoxiSense (1)
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  • ReninSense (1)
  • Superhance (1)
  • TLectinSense (1)
  • Transferrin-Vivo (1)
  • XenoLight (6)
Fluorescent Agent Type
  • Activatable (11)
  • Targeted (20)
  • Vascular (9)
Imaging Modality
  • Fluorescence (39)

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