PerkinElmer

Drug Discovery Reagents

OF

Drug discovery is a complex, costly, and time-consuming undertaking. And for research scientists, high-throughput screening is where the journey to discovery begins.

Your job is to move from target to hit to candidate quickly and efficiently – with as little wasted resources as possible. Our HTS screening reagents do just that, providing you with a wide range of validated reagents and kits in Alpha, LANCE®, DELFIA®, and other assay technologies.

Accelerate your workflow, while getting consistent, accurate, and physiologically relevant results.

AlphaLISA assay principle
AlphaLISA assay principle

Alpha Technology

Virtually anything can be measured with Alpha Technology quickly and easily, including enzymes, receptor-ligand interactions, low-affinity interactions, second messenger levels, DNA, RNA, proteins, protein:protein interactions, peptides, sugars and small molecules.

  • Ease-of-use: homogeneous, no-wash assay, with no separation steps
  • Fast: results in 3 hours for most applications
  • High sensitivity: detect down to femtogram levels of target
  • Large dynamic range: 4-5 logs
  • Compatible with many samples types: serum, plasma, cerbrospinal fluid (CSF), tissue extracts, cell culture supernatants, cell lysates, and more

Choose the Alpha solution that’s right for you

  • AlphaLISA® – when running large numbers of ELISA from the same sample or working with difficult matrix, serum or plasma
  • AlphaLISA SureFire Ultra and AlphaScreen SureFire – an excellent choice for studying pathways or phosphorylated proteins in whole cells, or studying endogenous receptors
  • AlphaScreen® – perfect for studying fusion-tagged proteins or protein: protein interactions, and for testing cAMP, phosphorylated peptides or samples in a simple matrix
  • Alpha Toolbox – when your target doesn’t have an off-the-shelf kit, the toolbox gives you everything you need to create your own
LANCE biomarker detection assay principle
LANCE biomarker detection assay principle

LANCE Ultra TR-FRET

From assay development to primary and secondary screening, LANCE Ultra Technology provides researchers with robust and easy-to-use assays adaptable to a variety of targets on a broad range of multimode detectors, with the fastest time-to-results in a commercially-available TR-FRET assay.

  • No-wash/separation steps
  • Homogeneous dispense-and-read technology
  • Sensitive detection
  • High reproducibility
  • Faster time-to-results
  • Easy automation
  • 384-well and 1536-well formats

LANCE and LANCE (LANthanide Chelate Excitation) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One binding partner of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and a second one is labeled with an acceptor fluorophore (ULight™ dye). Upon excitation at 320-340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light detectable at 665 nm.

DELFIA_trf
DELFIA_trf

DELFIA

DELFIA (Dissociation-Enhanced Lanthanide Fluorescence Immunoassay) is a proven, robust immunodetection platform based on time-resolved fluorescence (TRF) detection. This detection method, coupled with the unique chemical properties of lanthanide chelates, makes DELFIA a superior alternative to conventional ELISA for research, drug discovery, and clinical applications.

DELFIA offers a combination of high sensitivity, wide dynamic range and long-lasting stability that traditional ELISA cannot match. 

Reporter gene assay
Reporter gene assay

Reporter Gene Assays

Whether your assay requires the sensitivity provided by high signal intensity, or the flexibility of an extended signal half-life, PerkinElmer provides a solution. Choose from one of three luciferase detection systems: neolite, britelite plus, or steadylite plus depending on the specific requirements of your experiment.
  • No more washing – just add your lites reagent of choice, mix, incubate, and read
  • Hassle-free storage – all lites reagents are designed for extended storage at 2-8 °C (no -20 °C storage required)
  • Odor-friendly, eliminates hood work – lites products do not contain DTT and do not have the hazards and repugnant odor typical of conventional luciferase detection systems
  • Excellent Z’ values – superior S/B ratios allow for excellent Z’ values in antagonist and agonist studies
ATPlite assay principle
ATPlite assay principle

ATP Quantitation

For fast, reliable detection of ATP for cell quantitation, ATPlite 1step and ATPlite are innovative technologies that measure cell proliferation and cytotoxicity in mammalian cells based on the detection of ATP using firefly luciferase.

ATPlite 1step – Highest sensitivity

  • True “mix and measure” continuous processing
  • Ultra high sensitivity, 3 times more light output than ATPlite
  • Short equilibrium time for faster processing
  • Signal half-life of 30 minutes

ATPlite – Convenient, extended Signal

  • 2-step format, non-separation assay for time course studies; lysate can be stored frozen and tested later
  • Quantitate from <5 cells/well
  • Prolonged equilibrium time for batch processing
  • Signal half-life of 5 hours
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AlphaLISA Cellular Epigenetics kits

AlphaLISA Acetylated-Histone H3 Lysine 27 (H3K27ac) Cellular Detection Kit

This kit is designed for the detection of acetylated Histone H3 Lysine 27 (H3K27ac) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 675.00 USD - 12000.00 USD
AlphaLisa Analyte 2

Amyloid β 1-42 (human), lyophilized (AlphaLISA)

Human Amyloid beta 1-42 (Aß 1-42) (high specificity) standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA human Aß 1-42 kit, but can be ordered separately.
List Price : 514.00 USD
AlphaLISA immunoassay kits

GAD67 (Human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for GAD67 enables the quantitative determination of human glutamate decarboxylase 67 (hGAD67) in serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows less than 5% cross reactivity with mouse GAD67. Cross-reactivity with other species has not tested.
Price Range : 750.00 USD - 24000.00 USD

Anti-FITC AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to mouse monoclonal anti-FITC antibody. These beads can be used to capture FITC-tagged and fluorescein-labeled biomolecules for AlphaLISA no-wash assays.
Price Range : 571.00 USD - 23400.00 USD
AlphaLISA immunoassay kits

CD28 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human CD28 enables the quantitative determination of human CD28 in buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 582.00 USD - 14000.00 USD

GM-CSF (human) AlphaLISA Detection Kit

The AlphaLISA® Human Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) Detection Kit is designed for detection and quantitation of human GM-CSF in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 1476.00 USD - 9800.00 USD

CCL4 (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human CCL4/MIP-1ß Detection Kit is designed for detection and quantitation of human C-C Motif Chemokine 4/Macrophage Inflammatory Protein-1beta in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 773.00 USD - 10300.00 USD

FGF23 (Human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human FGF23 enables the quantitative determination of human FGF23 in human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The kit demonstrated no cross reactivity to FGF21 and very low reactivity to Mouse FGF23.
Price Range : 464.00 USD - 9500.00 USD
AlphaPlex Samarium Acceptor Beads

Anti-Human IgG AlphaPlex 645 (Sm) Acceptor beads

AlphaPlex™-645 (Samarium) Acceptor beads conjugated to anti-human IgG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 570.00 USD - 23400.00 USD
Protein

FGF23 (Human) lyophilized (AlphaLISA)

Human FGF23 standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA FGF23 Detection Kit, but can be ordered separately.
List Price : 233.00 USD

MMP-12 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human MMP-12 enables the detection and quantitation of human matrix metalloproteinase-12 in serum or cell culture medium using a homogeneous AlphaLISA assay (no wash steps). The kit was designed to detect both MMP12 and pro-MMP12.
Price Range : 433.00 USD - 9500.00 USD
AlphaLISA immunoassay kits

IFN-γ (mouse) AlphaLISA Detection Kit

The AlphaLISA® Mouse Interferon-γ (IFNγ) Detection Kit is designed for detection and quantitation of mouse IFNγ in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 1476.00 USD - 9800.00 USD
Protein

EGF (human), lyophilized (LANCE)

Human EGF standard, lyophilized, for use in running standard curves in LANCE Ultra TR-FRET Detection Assays. This standard is already provided in the LANCE Ultra Human EGF Detection Kit, but can be ordered separately.
List Price : 295.00 USD

Anti-c-myc AlphaLISA® Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-c-myc antibody. These beads can be used to capture c-myc-tagged proteins and peptides in AlphaLISA no-wash assays.
Price Range : 571.00 USD - 23400.00 USD
AlphaLISA immunoassay kits

FLT-1/VEGFR 1 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human VEGFR 1 (FLT-1) enables the quantitative determination of VEGFR 1 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 420.00 USD - 9200.00 USD
PerkinElmer
Price Range : 103.00 USD - 361.00 USD
AlphaLISA immunoassay kits

CRP (rhesus) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for rhesus C-reactive protein (CRP) enables the quantitative determination of rhesus CRP in buffered solution, cell lysates, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 420.00 USD - 9200.00 USD

Testosterone AlphaLISA Detection Kit

The AlphaLISA® Testosterone Research Kit is designed for detection and quantitation of testosterone in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 626.00 USD - 9800.00 USD
AlphaLISA immunoassay kits

IgG (mouse) AlphaLISA Detection Kit

The AlphaLISA immunoassay kit for detection and quantitation of mouse IgG in cell culture/non-mouse serum allows for fast, reproducible, and sensitive detection without the need for time-consuming wash steps or complicated assay development.
Price Range : 675.00 USD - 9400.00 USD
AlphaLisa Analyte 2

CD117 (human), lyophilized (AlphaLISA)

Human CD117 standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human CD117 Detection Kit, but can also be ordered separately.
List Price : 226.00 USD
AlphaLisa Analyte 2

Glucagon solution (AlphaLISA)

Glucagon solution, (100 µg/mL). This glucagon standard is already provided in the AlphaLISA Glucagon immunoassay kit, but can be ordered separately as a standalone product. One vial contains an amount of Glucagon sufficient for performing 10 standard curves.
List Price : 231.00 USD
Protein

ANGPTL3 (human), lyophilized (LANCE)

Human angiopoietin-like 3 (ANGPTL3) standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Human ANGPTL3 Detection Kit, but can also be ordered separately.
List Price : 233.00 USD
AlphaPlex-545-antibody-bead2

Anti-human IgG AlphaPlex 545 Acceptor Beads

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to anti-human IgG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 570.00 USD - 23400.00 USD

Cortisol LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Cortisol Detection Kit is designed for detection and quantitation of cortisol in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 1512.00 USD - 10300.00 USD
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-4E-BP1 (Thr37/46) Assay Kit

The AlphaLISA® SureFire® Ultra™ p-4E-BP1 (Thr37/46) assay is a sandwich immunoassay for quantitative detection of phospho-4EBP1 (phosphorylated on Thr37/46) in cellular lysates using Alpha Technology.
Price Range : 475.00 USD - 27500.00 USD

LANCE Ultra ULight™-poly GT

Poly Glu-Tyr (4:1) labeled with ULightTM dye. This random polymer is a Tyrosine kinase substrate.
Price Range : 307.00 USD - 838.00 USD
AlphaLISA immunoassay kits

p24 (human HIV) AlphaLISA Detection Kit

The AlphaLISA® Human Immunodeficiency Virus type-1 p24 protein (HIV p24) Detection Kit is designed for detection and quantitation of HIV p24 in buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 1476.00 USD - 9800.00 USD

BDNF (human) AlphaLISA Detection Kit

AlphaLISA no-wash immunoassay kit for detection and quantitation of Brain Derived Neurotrophic Factor (BDNF) in serum, cell culture supernatants, and other samples.
Price Range : 675.00 USD - 9800.00 USD

Cry2A AlphaLISA Detection Kit

The AlphaLISA® Cry2A Detection Kit is designed for detection and quantitation of Cry2A in GMO seeds, leaves, and plant extracts in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 582.00 USD - 9000.00 USD

DELFIA Eu-N1 Labeled Anti-Phosphothreonine Antibody, 10µg

Europium-labeled anti-phosphothreonine antibody, for use in DELFIA® time-resolved fluorescence (TRF) kinase assays.
List Price : 1246.00 USD
Protein

MANF (human) lyophilized (AlphaLISA)

Human MANF standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Human MANF Detection Kit, but can be ordered separately.
List Price : 295.00 USD
ATPlite 1-step kit

ATPlite 1step Luminescence Assay System

ATP-monitoring luminescence assay for quantitative evaluation of proliferation and cytotoxicity of cultured mammalian cells. The 1-step format only requires one addition step, and can be used for continuous processing.
Price Range : 59.00 USD - 2982.00 USD
AlphaLisa Analyte 2

GM-CSF (mouse), lyophilized (AlphaLISA)

Mouse Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Mouse GM-CSF kit, but can be ordered separately.
List Price : 514.00 USD
AlphaLISA immunoassay kits

CD86 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human CD86 enables the quantitative determination of human CD86 in buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 582.00 USD - 14000.00 USD
AlphaLisa Analyte 2

GLP-1 (7-36) (human), lyophilized (AlphaLISA)

Human GLP-1 (7-36) standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Human GLP-1 Detection Kit, but can be ordered separately.
List Price : 233.00 USD

ANGPTL4 (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human ANGPTL4 Detection Kit is designed for detection and quantitation of human angiopoietin-like 4 protein in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 773.00 USD - 10300.00 USD
AlphaLisa Analyte 2

FLT1/VEGFR 1 (human), lyophilized (AlphaLISA)

Human VEGFR 1 (FLT-1) standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human FLT-1 Detection Kit, but can also be ordered separately.
List Price : 226.00 USD

Anti-IgG1 AlphaLISA Acceptor beads

AlphaLISA® Acceptor beads conjugated to anti-human IgG1. These beads can be used in conjunction with Alpha Donor beads to create AlphaLISA no-wash assays for antibody binding studies, pharmacokinetics (PK), or detection of human IgG1 in different sample matrices, including monkey serum.
Price Range : 553.00 USD - 22700.00 USD

LANCE Ultra ULight™-anti-GST

Goat polyclonal anti-GST tag antibody labeled with ULight™ dye.
Price Range : 428.00 USD - 10800.00 USD
Protein

FSH (human), lyophilized (LANCE)

Human follicle stimulating hormone (FSH) standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra FSH Detection Kit, but can also be ordered separately.
List Price : 287.00 USD
Alpha donor antibody coated

Anti-DNP Alpha Donor Beads

Alpha Donor beads conjugated to anti-DNP antibody. These beads can be used to capture DNP-labeled proteins, peptides, and small molecules.
Price Range : 1545.00 USD - 18000.00 USD

DELFIA Eu-N1 Streptavidin

DELFIA® Europium-labeled streptavidin, for use in DELFIA time-resolved fluorescence (TRF) assays.
List Price : 369.00 USD

Nidogen 1 (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Nidogen 1 Detection Kit is designed for detection and quantitation of Nidogen 1 in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 773.00 USD - 10300.00 USD

c-Myc (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra c-Myc Detection Kit is designed for detection and quantitation of c-Myc peptide tag in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 773.00 USD - 10300.00 USD
AlphaLISA assay principle

ANGPT2 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human ANGPT2 enables the quantitative determination of human Angiopoietin 2 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 582.00 USD - 17500.00 USD
AlphaLISA immunoassay kits

hCG (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human chorionic gonadotropin (hCG) enables the quantitative determination of hCG in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 504.00 USD - 15100.00 USD

Anti-6xHis AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to anti-His antibody. The mouse monoclonal antibody detects proteins containing accessible consecutive histidine regions at the amino- or carboxy- terminus. These beads can be used to capture His-tagged proteins and peptides for AlphaLISA no-wash assays.
Price Range : 571.00 USD - 23400.00 USD
AlphaLisa Analyte 2

IL-17A (mouse), lyophilized (AlphaLISA)

Mouse Interleukin-17 (IL-17A) standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Mouse/Rat IL-17A kit, but can be ordered separately.
List Price : 240.00 USD
PerkinElmer

LANCE Ultra Europium-anti-phospho-eIF4E-binding protein 1 (Thr37/46)

Europium-labeled rabbit monoclonal antibody recognizing human eukaryotic translation initiation factor 4E-binding protein 1 phosphorylated at Thr37 or Thr46. Sequence motif recognized: ST(pT)PGGTLFST(pT)PG
(mono-phosphorylated peptides at either residue will also be successfully recognized)
Price Range : 1984.00 USD - 6900.00 USD
PerkinElmer

DELFIA® L*R wash concentrate (25x), 250 mL

Wash buffer for DELFIA® time-resolved fluorescence (TRF) ligand binding assays.
List Price : 99.00 USD

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