PerkinElmer

CNS Research

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CNS research seeks to advance treatment for central nervous system disorders through the discovery and quantitation of biomarkers, mechanisms, and drug targets. Our broad range of CNS products meets all the needs of in vitro, in situ, and in vivo central nervous system research.

We offer biomarker detection kits with AlphaLISA® and LANCE® TR-FRET technology, cellular and in vivo imaging systems, and tissue pathology solutions to assess mechanisms of CNS disease in biochemical, cellular, tissue, and animal models. We also provide target-specific radiochemicals, radioligands, and receptor-transfected cell lines and cell membranes.

Applications for our CNS products include:

  • Measuring biomarkers of CNS disease in cells, brain tissue homogenates, cerebrospinal fluid, and other sample types with our fast, pre-validated kits
  • Studying targeted binding using our radiolabeled ligands and steroids
  • Quantitating biomarkers in tissue samples with our industry-leading immunohistochemistry products
  • CNS research in animal models from molecular, functional, and anatomical perspectives with our in vivo imaging systems
  • Performing phenotypic analysis with our high content screening solutions

Our CNS products are also well suited for CNS research in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. Gain precise insight on disease biomarkers like phospho-tau, Ab42/Ab40, vimentin, and frataxin, as well as relevant receptors such as dopamine DA1R/DA2R.

Business Insights (2)
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1-2 of 2 Business Insights

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  • Application Note

    Measuring FRET using the Opera Phenix High-Content Screening System

    Fundamental processes in living cells, such as apoptosis and signal transduction are controlled by proteins, often acting in concert with other protein partners through protein-protein interactions (PPIs). Inappropriate protein-protein recognition can fundamentally contribute to many diseases, including cancer. Therefore, inhibiting protein-protein interactions represents an emerging area in drug design.

  • Application Note

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

Products & Services (189)
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Product Type
  • Accessories (34)
  • Consumables (2)
  • Reagents (147)
  • Software and Informatics (6)
Assay Target
  • Aβ1-40 (2)
  • Aβ1-42 (1)
  • Aβ1-x (1)
  • Aβ40 (3)
  • Aβ42 (1)
  • EPO (1)
  • Frataxin (2)
  • GAD67 (2)
  • NFL (1)
  • pNFH (1)
  • Tau (1)
  • TDP-43 (2)
Target Species
  • Human (16)
Application
  • cAMP (11)
  • Drug Discovery & Development (46)
  • Immunohistochemistry (IHC) (23)
  • In situ hybridization (ISH) (23)
  • Molecular Biology (2)
  • Protein Analysis & Detection (16)
Therapeutic Area
  • Angiogenesis (9)
  • Cardiovascular (37)
  • Central Nervous System (88)
  • CNS & Neurologic (1)
  • Diabetes (10)
  • Gastrointestinal (31)
  • Inflammation (51)
  • Metabolic (30)
  • Obesity (1)
  • Pain (21)
Product Brand Name
  • AequoScreen (14)
  • AequoZen (12)
  • AlphaLISA (10)
  • Ancillary Products (2)
  • cAMPZen (7)
  • LANCE Ultra (8)
  • Membrane Target Systems (35)
  • NEN (2)
  • NEN Radiochemicals (1)
  • Operetta (29)
  • Operetta CLS AND Opera Phenix (7)
  • TSA (12)
  • TSA Plus (12)
  • ValiScreen (15)
Detection Method
  • Alpha (10)
  • Chromogenic (6)
  • Fluorescence (25)
  • Radiometric (3)
  • Time-Resolved Fluorescence (TRF) (8)
  • TR-FRET (8)
Receptor Type
  • 5-Hydroxytryptamine (Serotonin) (38)
  • Adrenergic (10)
  • Cannabinoid (9)
  • Dopamine (8)
  • GABA (4)
  • Galanin (10)
  • Neurotensin (4)
  • Nicotinic (4)
  • Opioid (11)
  • Tachykinin (1)
Assay Validated
  • Binding (72)
  • Calcium Fluorescence (16)
  • Calcium Luminescence (32)
  • cAMP (20)
  • Downstream Phosphorylation (5)
  • GTPγS (19)
  • Inositol Phosphate (3)
Radioisotope
  • H-3 (1)
  • S-35 (2)
Radionuclide
  • 35S (2)
  • 3H (1)
Volume Capacity
  • 150 µL (2)
Nucleotide
  • UTP (2)
Fluorophore
  • Coumarin (1)
  • Cy3 (8)
  • Cy5 (4)
  • Fluorescein (6)
  • TMR (5)
Label Position
  • alpha (2)
  • Nominally Labeled (1)
Buffer
  • Tricine (2)
Assay points(200-50,000)
  • 100 (2)
  • 10000 (4)
  • 500 (13)
  • 5000 (9)
Assay Target Class
  • Cytokine (1)
  • GPCR (80)
  • Ion channel (3)
  • Peptide (7)
  • Protein (10)
Automation Compatible
  • Yes (18)
Concentration
  • 12.5 mCi/mL (1)
Experimental Type
  • In vitro (16)
Format
  • Microplates (16)
  • Slides (23)
Host Cell
  • 1321N1 (4)
  • CHO-K1 (65)
  • HEK293 (13)
  • L Cells (1)
  • UC11 (1)
Model Compatible With
  • Operetta (29)
  • Operetta CLS AND Opera Phenix (7)
Volume
  • 0-50 (1)

1-12 of 189 Products & Services

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  • Receptor-expressing cell lines

    AequoZen FroZen cells, Opioid mu, Human Recombinant, CHO-K1

    Our frozen, irradiated AequoZen cells express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
    List Price : 1009.00 USD
  • Protein

    Frataxin (human), lyophilized (LANCE)

    Human Frataxin standard, lyophilized, for use in running standard curves in LANCE TR-FRET no-wash detection assays. This standard is already provided in the LANCE Ultra Human Frataxin TR-FRET Detection Kit, but can be ordered separately.
    List Price : 250.00 USD
  • Aβ(1-40) (human) High Specificity LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra Human Aβ(1-40) High Specificity Detection Kit is designed for detection and quantitation of human Aβ(1-40) in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
    Price Range : 830.00 USD - 11100.00 USD
  • NFL (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human neurofilament light chain protein (NFL) enables the quantitative determination of human FABP3 in buffer and cerebrospinal fluid (CSF) using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 782.00 USD - 17500.00 USD
  • TSA Cyanine 3 System/Cyanine 5 System

    TSA Plus Cyanine 3 and Cyanine 5 System

    TSA® Plus multi-fluorophore detection kit, for amplification of multiple signals in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols.
    List Price : 708.00 USD
  • TAU (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Microtubule-associated Protein Tau (TAU) Detection Kit is designed for detection and quantitation of human TAU in cerebrospinal fluid (CSF), buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The antibodies used in the kit correspond to clone numbers BT2 and Tau 12.
    Price Range : 3036.00 USD - 23700.00 USD
  • Aß(1-40) (human), lyophilized (LANCE)

    Aβ(1-40) (human), lyophilized (LANCE)

    Human Aβ(1-40) standard, for use in running standard curves in LANCE TR-FRET no-wash detection assays. This standard is already provided in the LANCE Ultra Human Aβ(1-40) Detection Kit, but can be ordered separately.
    List Price : 250.00 USD
  • PerkinElmer

    Anti-DNP AP Conjugate

    Anti-DNP antibody conjugated to alkaline phosphatase
    List Price : 340.00 USD
  • Receptor-expressing cell lines

    AequoZen FroZen cells, Serotonin 5-HT1A, Human Recombinant, CHO-K1

    Our frozen, irradiated AequoZen cells express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
    List Price : 1009.00 USD
  • Receptor-expressing cell lines

    ValiScreen Opioid Kappa (OP2) (human) cell line

    Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
  • PerkinElmer

    TSA Biotin System

    TSA® biotin detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra biotin in the localized area of the probe or antibody.
    Price Range : 319.00 USD - 1063.00 USD
  • Receptor-expressing cell lines

    AequoZen Frozen cells, Adrenergic α2B, Human Recombinant, CHO-K1

    Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
    List Price : 1009.00 USD
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