PerkinElmer

CNS Research

OF

CNS research seeks to advance treatment for central nervous system disorders through the discovery and quantitation of biomarkers, mechanisms, and drug targets. Our broad range of CNS products meets all the needs of in vitro, in situ, and in vivo central nervous system research.

We offer biomarker detection kits with AlphaLISA® and LANCE® TR-FRET technology, cellular and in vivo imaging systems, and tissue pathology solutions to assess mechanisms of CNS disease in biochemical, cellular, tissue, and animal models. We also provide target-specific radiochemicals, radioligands, and receptor-transfected cell lines and cell membranes.

Applications for our CNS products include:

  • Measuring biomarkers of CNS disease in cells, brain tissue homogenates, cerebrospinal fluid, and other sample types with our fast, pre-validated kits
  • Studying targeted binding using our radiolabeled ligands and steroids
  • Quantitating biomarkers in tissue samples with our industry-leading immunohistochemistry products
  • CNS research in animal models from molecular, functional, and anatomical perspectives with our in vivo imaging systems
  • Performing phenotypic analysis with our high content screening solutions

Our CNS products are also well suited for CNS research in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. Gain precise insight on disease biomarkers like phospho-tau, Ab42/Ab40, vimentin, and frataxin, as well as relevant receptors such as dopamine DA1R/DA2R.

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Product Type
  • Accessories (34)
  • Consumables (2)
  • Reagents (149)
  • Software and Informatics (6)
Application
  • cAMP (11)
  • Drug Discovery & Development (46)
  • Immunohistochemistry (IHC) (23)
  • In situ hybridization (ISH) (23)
  • Molecular Biology (2)
  • Protein Analysis & Detection (20)
Assay points(200-50,000)
  • 10000 (5)
  • 500 (14)
  • 5000 (9)
Assay Target
  • Aβ1-40 (3)
  • Aβ1-42 (2)
  • Aβ1-x (1)
  • Aβ40 (3)
  • Aβ42 (1)
  • BDNF (2)
  • EPO (1)
  • Frataxin (2)
  • GAD67 (2)
  • Tau (1)
  • TDP-43 (2)
Assay Target Class
  • Cytokine (1)
  • GPCR (80)
  • Ion channel (3)
  • Peptide (9)
  • Protein (10)
Assay Validated
  • Binding (72)
  • Calcium Fluorescence (16)
  • Calcium Luminescence (32)
  • cAMP (20)
  • Downstream Phosphorylation (5)
  • GTPγS (19)
  • Inositol Phosphate (3)
Automation Compatible
  • Yes (20)
Buffer
  • Tricine (2)
Concentration
  • 12.5 mCi/mL (1)
Detection Method
  • Alpha (10)
  • Chromogenic (6)
  • Fluorescence (25)
  • Radiometric (3)
  • Time-Resolved Fluorescence (TRF) (10)
  • TR-FRET (10)
Experimental Type
  • In vitro (20)
Fluorophore
  • Coumarin (1)
  • Cy3 (8)
  • Cy5 (4)
  • Fluorescein (6)
  • TMR (5)
Format
  • Microplates (20)
  • Slides (23)
Host Cell
  • 1321N1 (4)
  • CHO-K1 (65)
  • HEK293 (13)
  • L Cells (1)
  • UC11 (1)
Label Position
  • alpha (2)
  • Nominally Labeled (1)
Nucleotide
  • UTP (2)
Product Brand Name
  • AequoScreen (14)
  • AequoZen (12)
  • AlphaLISA (10)
  • Ancillary Products (2)
  • cAMPZen (7)
  • LANCE Ultra (10)
  • Membrane Target Systems (35)
  • NEN (2)
  • NEN Radiochemicals (1)
  • Opera Phenix (7)
  • Operetta (29)
  • TSA (12)
  • TSA Plus (12)
  • ValiScreen (15)
Radionuclide
  • 35S (2)
  • 3H (1)
Radioisotope
  • H-3 (1)
  • S-35 (2)
Receptor Type
  • 5-Hydroxytryptamine (Serotonin) (38)
  • Adrenergic (10)
  • Cannabinoid (9)
  • Dopamine (8)
  • GABA (4)
  • Galanin (10)
  • Neurotensin (4)
  • Nicotinic (4)
  • Opioid (11)
  • Tachykinin (1)
Target Species
  • Human (18)
  • Mouse (2)
Therapeutic Area
  • Angiogenesis (9)
  • Cardiovascular (37)
  • Central Nervous System (91)
  • CNS & Neurologic (1)
  • Diabetes (10)
  • Gastrointestinal (31)
  • Inflammation (51)
  • Metabolic (30)
  • Obesity (1)
  • Pain (21)
Volume
  • 0-50 (1)
Volume Capacity
  • 150 µL (2)

"CNS Research" 1-50 of 191 Products and Services

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PerkinElmer

Membrane Target Systems: Serotonin 5HT-6 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

BDNF (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human BDNF Detection Kit is designed for detection and quantitation of human BDNF in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 773.00 USD - 10300.00 USD
Receptor-expressing cell lines

AequoZen Frozen cells, Serotonin 5-HT2C (non edited isoform), Human Recombinant, CHO-K1

Our frozen, irradiated AequoZen cells express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 961.00 USD
AlphaLISA immunoassay kits

EPO (human) AlphaLISA Detection Kit

The AlphaLISA® Human Erythropoietin (EPO) Detection Kit is designed for detection and quantitation of human EPO in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 2912.00 USD - 22800.00 USD
Receptor-expressing cell lines

ValiScreen Serotonin 5HT-6 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Protein

BDNF (human), lyophilized (LANCE)

Human brain-derived neurotrophic factor (BDNF) standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra BDNF Detection Kit, but can also be ordered separately.
List Price : 295.00 USD
TSA -Plus Tetramethylrhodamine System

TSA Plus TMR

TSA® Plus tetramethylrhodamine (TMR) detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra TMR in the localized area of the probe or antibody.
Price Range : 394.00 USD - 1727.00 USD
AlphaLISA immunoassay kits

Amyloid β 1-42 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for detection and quantitation of human Amyloid β 1-40 (Aβ 1-40) in cerebrospinal fluid (CSF), cell culture supernatants, and other sample types allows for fast, reproducible, and sensitive detection without the need for time-consuming wash steps or complicated assay development.
Price Range : 2912.00 USD - 22800.00 USD
PerkinElmer

TSA Plus Biotin

TSA® Plus Biotin detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra biotin in the localized area of the probe or antibody.
Price Range : 368.00 USD - 1380.00 USD
AlphaLISA immunoassay kits

Amyloid β 1-42 (high specificity) (human) AlphaLISA Detection Kit

The AlphaLISA® Human Amyloid beta 1-42 (Aß 1-42) (high specificity) Detection Kit is designed for detection and quantitation of human Aß 1-42 in cerebrospinal fluid (CSF), buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 2912.00 USD - 22800.00 USD
Receptor-expressing cell lines

ValiScreen Nicotinic HM74a (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
AlphaLISA immunoassay kits

TAU (human) AlphaLISA Detection Kit

The AlphaLISA® Human Microtubule-associated Protein Tau (TAU) Detection Kit is designed for detection and quantitation of human TAU in cerebrospinal fluid (CSF), buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The antibodies used in the kit correspond to clone numbers BT2 and Tau 12.
Price Range : 2912.00 USD - 22800.00 USD
PerkinElmer

TSA Plus Fluorescein

TSA® Plus fluorescein detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra fluorescein in the localized area of the probe or antibody.
Price Range : 216.00 USD - 1727.00 USD
PerkinElmer

Membrane Target Systems: Adrenergic alpha 2A (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Serotonin 5HT-5A (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Adenosine 5 Triphosphate 250 µCi

Mannose, D-[2-3H(N)]-, Specific Activity: 15-30Ci (555GBq-1.11TBq)/mmol, 5mCi (185MBq)

5 mCi quantities of D-[2-3H(N)]-Mannose are available for your research.
List Price : 2847.00 USD
PerkinElmer

Membrane Target Systems: GABA B1b (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human GABA B1b receptor, 400 units.
List Price : 936.00 USD
Receptor-expressing cell lines

Cannabinoid CB1AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
PerkinElmer

TSA Plus Cyanine 3 System, for 50-150 Slides

TSA® Plus Cyanine 3 (Cy3) detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra Cy3 in the localized area of the probe or antibody.
List Price : 394.00 USD
PerkinElmer

Membrane Target Systems: Serotonin 5HT-2C (e) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Dopamine D2L, Human Recombinant, CHO-K1

Our frozen, irradiated AequoZen cells express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 961.00 USD
Receptor-expressing cell lines

Galanin Gal2 AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
PerkinElmer

Membrane Target Systems: Galanin Gal2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
AlphaLISA immunoassay kits

Amyloid β 1-42 (mouse/rat) AlphaLISA Detection Kit

The AlphaLISA® Mouse/Rat Amyloid beta (Aß 1-42) Detection Kit is designed for detection and quantitation of mouse or rat Aß 1-42 in serum, cerebrospinal fluid (CSF), buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 2912.00 USD - 22800.00 USD
TSA -Plus Cyanine 3 System

TSA Plus Cyanine 3

TSA® Plus Cyanine 3 (Cy3) detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra Cy3 in the localized area of the probe or antibody.
Price Range : 216.00 USD - 1727.00 USD
Receptor-expressing cell lines

Adrenergic alpha 2B AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
Receptor-expressing cell lines

ValiScreen Serotonin 5HT-2C (ne) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
LANCE Detection Kit

Aβ(1-40) (human) High Specificity LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human Aβ(1-40) High Specificity Detection Kit is designed for detection and quantitation of human Aβ(1-40) in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 796.00 USD - 10600.00 USD
Protein

TDP-43 (human), liquid (LANCE)

Human TDP-43 standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Human TDP-43 TR-FRET Detection Kit, but can also be ordered separately.
List Price : 295.00 USD
Receptor-expressing cell lines

Galanin Gal1 AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
Amplification Diluent

TSA Cyanine 5 Tyramide Reagent Pack, Reagents for 50-150 Slides

TSA® Cyanine 5 (Cy5) reagent pack, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. These reagents amplify by depositing extra biotin in the localized area of the probe or antibody.
List Price : 317.00 USD
PerkinElmer

Membrane Target Systems: Dopamine D1 (human) membrane preparation, in L cells cells. 400 Units.

Cell membranes prepared from L cells stably-transfected with human dopamine D1 receptor, 400 units.
List Price : 936.00 USD
AlphaLISA immunoassay kits

Amyloid β 1-40 (mouse/rat) AlphaLISA Detection Kit

The AlphaLISA® Mouse/Rat Amyloid beta (Aß 1-40) Detection Kit is designed for detection and quantitation of mouse or rat Aß 1-40 in serum, cerebrospinal fluid (CSF), buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 3110.00 USD - 22800.00 USD
TSA Cyanine 3 & 5, TMR, Fluorescein Evaluation Kit

TSA Cy 3, Cy 5, TMR, Fluorescein Evaluation Kit

TSA® Plus multi-fluorophore detection kit, for amplification of multiple signals in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols.
List Price : 437.00 USD
TSA Plus DNP (AP)System

TSA Plus DNP (AP)

TSA® Plus DNP (AP) detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. The deposited DNP is detected using an anti-DNP alkaline phosphatase, with appropriate substrate.
Price Range : 275.00 USD - 491.00 USD
Receptor-expressing cell lines

Serotonin 5-HT6 AequoScreen; cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
Amplification Diluent

TSA Tetramethylrhodamine Tyramide Reagent Pack, Reagents for 100-300 Slides

TSA® tetramethylrhodamine (TMR) reagent pack, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. These reagents amplify by depositing extra biotin in the localized area of the probe or antibody.
List Price : 557.00 USD
Receptor-expressing cell lines

AequoZen FroZen cells, Serotonin 5-HT3A, Human Recombinant, HEK293

Our frozen, irradiated AequoZen cells express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
List Price : 961.00 USD
PerkinElmer

Membrane Target Systems: GABA B1b in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1b receptor, 400 units.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Adrenergic alpha 2C (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Receptor-expressing cell lines

5-Hydroxytryptamine 5-HT3A (Serotonin) AequoScreen Cell Line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
TSA Cyanine 3/Fluorescein System

TSA Plus Cyanine 3 and Fluorescein System

TSA® Plus multi-fluorophore detection kit, for amplification of multiple signals in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols.
List Price : 681.00 USD
PerkinElmer

Membrane Target Systems: Opioid Mu (OP3) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Receptor-expressing cell lines

Serotonin 5-HT2C (edited) AequoScreen; cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.

GAD67 (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human GAD67 Detection Kit is designed for detection and quantitation of Glutamic acid decarboxylase 67 in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 773.00 USD - 10300.00 USD
TSA -Plus Cyanine 5 System

TSA Plus Cyanine 5

TSA® Plus Cyanine 5 (Cy5) detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra Cy5 in the localized area of the probe or antibody.
Price Range : 216.00 USD - 1727.00 USD
AlphaLISA immunoassay kits

Aβ 1-40 (human) High Specificity AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human Aβ40 enables the detection and quantitation of human Aβ40 in human cerebrospinal fluid and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows negligible cross-reactivity with other forms of Amyloid beta (i.e. Aβ1-38 and Aβ1-42).
Price Range : 2827.00 USD - 22100.00 USD
PerkinElmer

Membrane Target Systems: Serotonin 5HT-2B (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Receptor-expressing cell lines

Serotonin 5-HT5A AequoScreen; cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
PerkinElmer

Membrane Target Systems: Serotonin 5HT6 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Serotonin 5-HT6 receptor, in HEK-293 cells.
List Price : 936.00 USD

"CNS Research" 1-50 of 191 Products and Services

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