PerkinElmer

Cardiovascular Disease Research

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Cardiovascular disease is a leading cause of death globally, and understanding its causes is critical for treatment and preventative care. Our phenotypic and target-based products support your cardiovascular disease detection and research, allowing greater visibility into the mechanisms that cause it.

The study of angiotensin, troponin, adiponectin, apolipoprotein, adrenergic receptors, and factors affecting cardiotoxicity is a major component of cardiovascular disease research, and requires effective detection and imaging as well as the ability to detect key biomarkers.

We offer a broad range of products to help you research cardiovascular disease. Our cardiovascular disease research products allow you to:

  • Quickly and simply detect and quantitate the biomarkers of cardiovascular disease with our fast, simple, pre-validated kits and multimode plate readers
  • Effectively conduct targeted binding studies using our radiolabeled ligands and lipids
  • Probe biological processes and study treatment efficacy in animal models from molecular, functional and anatomical perspectives with our in vivo imaging systems
  • Gain deeper insights from phenotypic analysis with our high content screening solutions

Business Insights (8)
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1-8 of 8 Business Insights

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  • Application Note

    MicroCT Investigation of Bone Erosion and Deformation in an Osteoarthritic Rat Model

    Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of bones within the joints gradually deteriorates, causing synovitis and joint deformation.

    The goal of OA research is to identify new therapeutic strategies that could prevent, reduce, halt progression, or repair the existing damage to the joint. Non-invasive in vivo imaging such as microCT is the standard modality for bone research due to its ability to obtain high-resolution images at an x-ray dose low enough as not to harm the animal. This makes microCT ideal for monitoring disease progression and response to treatments in the same animal over time. However, microCT data visualization and analysis can be cumbersome and time consuming. In this application note, we compared standard microCT software and advanced bone software to investigate bone erosion in an OA rat model.

  • Application Note

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • Application Note

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera® system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • Application Note

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS™ high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony® software contribute to the robustness of the high-content assay.

  • Application Note

    Contrast-enhanced Imaging of Vasculature and Soft Tissues Using the Quantum GX MicroCT System

    X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood vessels and internal organs share similar x-ray attenuation characteristics and are not distinguishable under typical CT settings. In order to introduce density that would improve soft tissue contrast, several contrast agents have been developed for use in clinical and preclinical settings. This application note outlines the use of iodine and nanoparticle-based contrast agents for imaging soft tissues and vasculature in various organs using the Quantum GX to gain further insights into disease and therapeutic response.

  • Application Note

    Measuring FRET using the Opera Phenix High-Content Screening System

    Fundamental processes in living cells, such as apoptosis and signal transduction are controlled by proteins, often acting in concert with other protein partners through protein-protein interactions (PPIs). Inappropriate protein-protein recognition can fundamentally contribute to many diseases, including cancer. Therefore, inhibiting protein-protein interactions represents an emerging area in drug design.

  • Application Note

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • Case Study

    High-Content Analysis of Drug-Induced Oligodendrocyte Differentiation Promoting Remyelination in Multiple Sclerosis

    One of the greatest challenges in multiple sclerosis (MS) therapy is the halting or reversal of the failure of remyelination in the brain in order to reverse disabilities in MS patients. This case study highlights the recent work of Dr. Paul Tesar and colleagues at the Case Western Reserve University School of Medicine, which could potentially lead to such novel treatments, as it aims to control the function of stem cells in the body and thereby to help the body repair itself.

Products & Services (57)
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Product Type
  • Accessories (12)
  • Instruments (3)
  • Reagents (37)
  • Software and Informatics (5)
Assay Target
  • cardiac Troponin I (1)
  • Cardiac Troponin T (2)
  • CHO HCP (1)
  • D-dimer (1)
  • FABP3 (1)
  • ICAM-1 (1)
  • Myeloperoxidase (1)
  • Myoglobin (1)
  • PAI-1 (1)
  • PCSK9 (1)
  • tPA (2)
Target Species
  • CHO (1)
  • Human (11)
Application
  • cAMP (6)
  • Drug Discovery & Development (17)
  • Protein Analysis & Detection (12)
Therapeutic Area
  • Angiogenesis (7)
  • Biologics/Bioprocess (1)
  • Cardiovascular (36)
  • Central Nervous System (10)
  • Diabetes (4)
  • Gastrointestinal (4)
  • Inflammation (14)
  • Metabolic (4)
  • Pain (4)
Product Brand Name
  • AequoScreen (4)
  • AequoZen (4)
  • AlphaLISA (11)
  • cAMPZen (3)
  • LANCE Ultra (2)
  • Membrane Target Systems (5)
  • NEN Radiochemicals (3)
  • Opera Phenix (1)
  • Operetta (2)
  • Operetta CLS (9)
  • Operetta CLS AND Opera Phenix (2)
  • Quantum (1)
  • ValiScreen (5)
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  • Alpha (11)
  • Fluorescence (2)
  • Radiometric (3)
  • Time-Resolved Fluorescence (TRF) (2)
  • TR-FRET (2)
  • Transmission (2)
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  • Adenosine (10)
  • Adrenergic (4)
  • Angiotensin (7)
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  • Binding (14)
  • Calcium Fluorescence (4)
  • Calcium Luminescence (8)
  • cAMP (6)
  • Downstream Phosphorylation (2)
  • GTPγS (2)
  • Inositol Phosphate (1)
Radioisotope
  • C-14 (3)
Radionuclide
  • 14C (3)
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  • Specifically Labeled (3)
Assay points(200-50,000)
  • 100 (2)
  • 10000 (1)
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  • 5000 (10)
Assay Target Class
  • GPCR (21)
  • Protein (13)
Automation Compatible
  • Yes (15)
Concentration
  • <1.0 mCi/mL (3)
Experimental Type
  • In vitro (12)
Format
  • Microplates (12)
Host Cell
  • CHO-K1 (17)
  • HEK293 (4)
Imaging Modality
  • High Content (2)
  • microCT Imaging (1)
Length
  • 51-100 (1)
  • 101-200 (1)
  • 901-1000 (1)
Model Compatible With
  • Operetta (2)
  • Operetta CLS (8)
  • Operetta CLS AND Opera Phenix (2)

1-12 of 57 Products & Services

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  • 1000x1000_Opera_Phenix

    Opera Phenix High-Content Screening System

    The Opera Phenix High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.
  • Quantum GX2 microCT imaging system

    Quantum GX2 microCT Imaging System

    Image beyond bone – into oncology, cardiovascular and pulmonary diseases, and much more, with the Quantum GX2 microCT imaging system. With the Quantum GX2, flexibility is key. Combining the ability to perform high speed, low dose scans, ideal for longitudinal studies, across multiple species (mice, rats, rabbits) with high resolution ex vivo scanning, the Quantum GX2 microCT imaging system offers the flexibility and performance you need to not just image, but further understand your disease models.
  • 1000x1000_Operetta

    Operetta CLS High-Content Analysis System

    Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.
  • AlphaLISA immunoassay kits

    ICAM-1 (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Intercellular Adhesion Molecule-1 (ICAM-1) Detection Kit is designed for detection and quantitation of human ICAM-1 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The antibodies target the extracellular domain of ICAM-1. The analyte in this kit consists of the extracellular domain of human ICAM-1.
    Price Range : 3036.00 USD - 23700.00 USD
  • AlphaLISA immunoassay kits

    Myoglobin (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Myoglobin Detection Kit is designed for detection and quantitation of human myoglobin in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 3036.00 USD - 23700.00 USD
  • CHO HCP LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra CHO HCP Detection Kit is designed for detection and quantitation of CHO host cell proteins in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
    Price Range : 830.00 USD - 11000.00 USD
  • Tissue Plasminogen Activator (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Tissue Plasminogen Activator (tPA) Detection Kit is designed for detection and quantitation of human tPA in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The kit was designed to detect both tPA and pro-tPA.
    Price Range : 1585.00 USD - 10500.00 USD
  • Cardiac Troponin I (human) AlphaLISA Detection Kit

    The AlphaLISA® Human cardiac Troponin I Detection Kit is designed for detection and quantitation of human cardiac Troponin I in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 3036.00 USD - 23700.00 USD
  • AlphaLISA immunoassay kits

    Myeloperoxidase (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Myeloperoxidase (MPO) Detection Kit is designed for detection and quantitation of human MPO in buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 3242.00 USD - 23700.00 USD
  • Receptor-expressing cell lines

    Adenosine A1 AequoScreen cell line

    Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
  • FABP3 (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human fatty acid binding protein 3 (FABP3) enables the quantitative determination of human FABP3 in buffer, cell cultrue media, and serum using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 750.00 USD - 11100.00 USD
  • Membrane Target Systems

    Membrane Target Systems: Angiotensin AT1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

    Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
    List Price : 982.00 USD
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