Come and visit us at one of our upcoming events where our team will be available to tell you more about our Phenoptics™ Research Solutions for Cancer Immunology & Immunotherapy and answer your questions.
PerkinElmer Hosted Events
Join our LIVE On-Demand Webinar: The Beginning of the End: Immunoprofiling Coming of Age
This webcast will provide a brief overview of multiplex immunofluorescence methods and then present results from a recent study demonstrating the prognostic power of assessing the composition and relationships of cells in the tumor microenvironment in-situ in FFPE tissue sections. These results provide insights into how this information could be used to stratify patients for enrollment on clinical trials, evaluate drug mechanisms of action and potentially identify patients in need of aggressive therapy. Ultimately, this capability should accelerate the development of immuno-oncology agent combinations and improve outcomes for patients with cancer.
During the webcast you will:
Online Webinar: Using Multiplexed IHC to Effectively Navigate the Hidden Clues of the Immunological Microenvironment, in situ, of Cancer
Therapies like ipilimumab and nivolumab have shown the potential for approaches that direct the patient’s own immune system against tumors. Further advances will require a detailed understanding of the tumor microenvironment and characterization of the location and status of immune cells and their interaction with tumor cells. This will require methods that provide phenotyping of immune and cancer cells combined with the cytoarchitectonics of the tumor. To achieve this, a practical method for simultaneous immunohistochemistry of up to 8 biomarkers in a single tissue section using standard unlabeled primary antibodies will be described. In addition, approaches for multiplexed imaging, single cell quantitative analysis, automated phenotyping and bioinformatics that enable new insights into cancer biology and immunology will be presented. These will then be leveraged in analyses of multiple cancer types, where it is established that the host-tumor interaction is complex and difficult to characterize with standard immunohistochemistry or flow cytometry. But by leveraging multiplexed IHC in situ, we will demonstrate the unique spatial relationships of immune phenotypes in and around both epithelial and non-epithelial tumor types, and show how this data has the potential to form the basis of assays that can guide therapy and monitor response. Further data regarding functional assessment of regulatory immunologic co-factor expression will be discussed.
Online Webinar: Multiplexed Immunohistochemistry: Illuminating the Tumor Microenvironment to Study Cancer-immune Mechanisms
As immuno-oncology takes center stage in the battle against cancer, the need for biomarkers has become even more acute, with response rates continuing in the 20%–30% range and the menu of options, including combination therapies, growing at an accelerating pace. The specific immunoarchitecture characteristics of the microenvironment in which a particular tumor grows may be both prognostic and predictive of response to these new immunotherapies. Multiplex immunofluorescence is the most effective, efficient way to identify specific immune cell types, their location, and their state of activation, as well as the presence of immunoactive molecular expression, all at the same time. This method is highly beneficial for exploring immune evasion mechanisms and finding potential biomarkers that allow researchers to assess the mechanism of action and predict and track response. This live, online seminar will take the viewer through validation of this multiplexing technique, including a comparison with singleplex immunofluorescence and standard (chromogenic) immunohistochemistry, as well as an assessment of intersite reproducibility and the influence of staining order on quantitation.
During the webinar, the viewers will:
Multispectral Imaging Roadshows
PerkinElmer will be partnering with industry experts to host a series of local Lunch & Learn workshops in the United States. Join us to learn about how our technologies are transforming cancer research to provide better visualization and identification of cancer immunology biomarkers. We'll showcase our complete Phenoptics Research Solutions for Immuno-Oncology, from multiplex immunohistochemistry staining solutions, multispectral imaging systems, and advanced image-analysis software, and invite speakers from Indica Labs, Columbia University, and more! Sign up for one of our four roadshows. Limited spots available. Dates and locations to be released soon.