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EnSight Multimode Plate Reader

The EnSight multimode plate reader combines labeled, label-free* & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.

*Label free detection module of EnSight Plate Reader is available outside the EU. Please contact your local representative for further details.

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The EnSight system's cell-imaging option, brings image-based cytometry together with our industry-leading detection technologies for the first time. Imaging is fast, with online data analysis in minutes.

The system has a modular design that lets you add detection modes as your needs change, and combined with workflow-based Kaleido data acquisition and analysis software, you have a truly versatile plate reader that gets users productive quickly – making it ideal for multiuser environments.

  • Well-imaging, label-free technology, Alpha technology and conventional multimode detection technologies all on a single benchtop system
  • Easily configurable and field upgradable
  • Base unit with filter-based absorbance technology and temperature control unit (up to 65°C)
  • Eight barcode identified filter positions
  • Integrated barcode reading from all four sides of a microplate
  • Kaleido Data Acquisition and Analysis Software


  • Fluorescence well-imaging with single cell resolution for up to four colors (with excitation of three colors in parallel), brightfield and digital phase-contrast imaging
  • Corning® Epic® optical label-free technology
  • AlphaLISA® / AlphaScreen® detection with high power laser excitation
  • Fluorescence intensity detection (top- and bottom-reading) with monochromator
  • Time-resolved fluorescence detection, for example DELFIA® and LANCE® technologies
  • Ultra-sensitive luminescence for low signals
  • Filter- and optional monochromator-based absorbance detection

Key Features:

  • Temperature control to 65°C
  • Plate barcode reader
  • Plate shaking
  • NEW Plate stackers, 20 plates or 50 plates
  • Robotic Interface for automation solutions

Disclaimer:  For research use only. Not for use in diagnostic procedures.


Automation Compatible Yes
Detection Method Absorbance, Image-based Cytometry, Time-Resolved Fluorescence (TRF), Luminescence, Alpha, Fluorescence, Label-free
Product Brand Name EnSight

Resources, Events & More

All (16)
Resource Type File Name File Format
Brochure Drug Discovery Screening Solutions Brochure PDF  880 KB
Brochure EnSight Multimode Plate Reader Brochure PDF  9 MB
Brochure Multimode Plate Reader Portfolio Brochure PDF  1 MB
Application Note Cell Counting and Confluency Analysis as Quality Controls in Cell-Based Assays PDF  4 MB
Application Note Morphology and ATP-based Cytotoxicity Profiling of Cancer Cell Lines PDF  1 MB
Application Note Multiparametric Analysis of Cytotoxicity using Cell Imaging in Combination with Luminescence PDF  1 MB
Application Note A New Approach for Automated Quantification of Cell Migration Link
Application Note Identifying Pharmacological Chaperones for the Cellular Prion Protein using a Label-free Biochemical Assay on the EnSight Multimode Plate Reader Link
Application Note Screening for Modulators of Smooth Muscle Cell Motility using EnSight Multimode Plate Reader Link
Application Note Comparing Transfection Reagent Efficiency by Imaging and Cell Counting on the EnSight Multimode Plate Reader Link
Application Note Determination of Transfection Efficiency using the EnSight Multimode Plate Reader Link
Event Society of Laboratory Automation & Screening (SLAS)
Webinars More Predictive Results in Cell-Based Assays: Combining Target-Based & Phenotypic Approaches Link
Webinars Cell-Imaging and Luminescence Based Cytotoxicity Analysis using the EnSight Multimode Plate Reader Link
Webinars Cellular Applications for Image-based Cytometry on A Multimode Plate Reader Link
White Paper Five Reasons Why You Need Imaging on Your Multimode Plate Reader Link