LabChip GX Software Readme Software Version: LabChip GX V4.2 SP1 This file provides information about LabChip GX software. Please read this information carefully as it supersedes all printed material or Online Help. Overview The LabChip GX software controls the LabChip GX and LabChip GX II instruments. The LabChip GX software is also used to analyze and compare data in the form of gels or graphs across different wells from the same or different LabChip GX data files. The software can also compare data with similar characteristics by applying filters. Results can be exported to graphic files or .csv (comma separated values) files. The software can be installed in Reviewer mode to be used only for data analysis. The 21 CFR Part 11 option can be installed on the LabChip GX computer to comply with 21 CFR Part 11 requirements. To use the 21 CFR Part 11 option, the Caliper 21 CFR Part 11 USB key must be installed. The 21 CFR Part 11 option supports remote data backup to a database on a network server. Use the CDR Server Utility software to set up the remote server. System Requirements for LabChip GX Software (Instrument Mode) LabChip GX software only supports the following Windows Operating Systems: U.S English Version of Microsoft® Windows XP Service Pack 3 or higher OR U.S. English, Professional Full Version of Microsoft® Windows 7 (32-bit) SP1 or higher Minimum RAM: 1Gb (2Gb recommended) System Requirements for LabChip GX Software (Reviewer Mode) LabChip GX software in Reviewer Mode only supports the following Windows Operating Systems: U.S English Version of Microsoft® Windows XP Service Pack 3 or higher OR U.S. English, Professional Full Version of Microsoft® Windows 7 (32-bit and 64-bit) SP1 or higher Minimum RAM: 1Gb (2Gb recommended) System Requirements for Remote CDR Server The Caliper Remote CDR Server only supports the 32-bit version of the following Windows Operating Systems: U.S. English Version of Microsoft® Windows XP Service Pack 3 or higher, OR Microsoft® Windows 7 Available Hard Disk Space: 10 - 20Gb (depending on use) Minimum RAM: 1Gb (2Gb recommended) LabChip GX Software Installation To install the LabChip GX software, you must be logged into the LabChip GX computer as a Windows Administrator. To run the LabChip GX software, the user must be an Administrator, Restricted User, Standard User, or Power User. To install the LabChip GX software on Windows XP or Windows 7: 1. Close all open programs. 2. Insert the LabChip GX Installation media. 3. Follow the instructions in the InstallShield wizard. If the installation does not start automatically: 1. Close all open programs. 2. In Windows Explorer, double-click setup.exe. 3. Follow the instructions in the InstallShield wizard. CDR Server Utility Software Installation To install or set up the remote CDR, you must log onto the Remote Server computer as a Windows administrator. For security purposes, files and folders on the remote server computer should not be shared or accessible by regular users on the network. If Subversion V1.5 or higher is installed on the remote server, a dialog prompts you to manually uninstall subversion. Installation will not continue until Subversion is uninstalled. After manually uninstalling Subversion, restart the installation. To install the CDR Server Utility software on Windows XP or Windows 7: 1. In Windows Explorer, double-click CDRServerUtilitySetup.exe. 2. Follow the instructions in the InstallShield wizard. 3. If this is the first time the CDR Server Utility is installed, you must restart the computer. To start the CDR Server Utility software, right-click on the desktop icon and select ‘Run as Administrator.’ Troubleshooting Remote CDR Server installation: 1. After creating the server, verify the windows service ‘Subversion’ is running. 2. The Remote and Local computers should be in the same workgroup. If they are not in same workgroup, use the IP Address instead of the computer name when specifying the remote CDR server on the LabChip GX computer. 3. After creating the server and folder, if the Get Folder Details check box was selected, the server name, folder name, username, and password are saved in a text file in “C:\Program Files\Caliper Life Sciences\CDRServer\ServerDetails”. This information is required for backing up the local folder on the LabChip GX computer to the remote CDR folder. Uninstall To uninstall the LabChip GX software: 1. From the Start menu, select Control Panel. 2. Double click on Add or Remove Programs in the Control Panel. 3. Select LabChip GX from the list of installed programs. 4. Click on the Remove button to uninstall the LabChip GX software. LabChip GX V4.2 SP1: New Features: · Lower limit of GQS region can now be changed in gDNA assays. (LCF-5551) · HT gDNA assay script improved to reduce DNA aggregates. (LCF-5559) Resolved Issues: · GQS definition redefined to improve under-scoring of partially degraded samples. (LCF-5547) · Default smear name (Total Smear) in gDNA assay changed to Total gDNA for better clarity. (LCF-5548) · Changed reporting of concentration to plate concentration (instead of input concentration). (LCF-5548) · Fixed issue where negative areas for the GQS smear regions are being used in the GQS calculation. (LCF-5495) · RunInfo viewer now displays Time in 12 hr format with AM/PM modifier. (LCF-5517) · The Clog Test limits in the Diagnostics Limits report are now more clearly explained. (LCF-5523) LabChip GX V4.1: New Features: · LabChip GX V4.1 supports the new gDNA assay. (LCF-5398) · The installer now checks the Operating System version and displays a warning if the Operating System is not a supported version. (LCF-5372) · The Expiration date of Test Chips now displays in the Chip Status area. (LCF-5416) · Calculation of Smear Molarity has been improved. The Smear is now segmented into evenly spaced segments, based on the time specified in the Advanced tab of the Analysis Settings and Assay Editor window. Smear Molarity is calculated using the concentration and center size of each segment. All existing data files will use this new calculation with Integration Step Size set to 0.2 seconds. Existing files may report different Smear Molarity. The new value is more accurate. (LCF-5385) Resolved Issues: · Resolved an issue where Well Label was duplicated in the Sample Name Editor during a run. (LCF-5402) · Resolved an issue where Export Table with Size reports N/A when first ladder fails analysis. (LCF-5477) · Resolved an issue where the LabChip GX software would display an “Invalid File” error when setting the run parameters using the LabChip GX Automation Control software. (LCF-5379) · Adding manual peaks when the sample data is shorter than the ladder data is now supported and does not cause an Unhandled Exception error. (LCF-5380) · The Event Log now displays a maximum of 10,000 messages, instead of 50,000, to prevent a “Parameter is not valid” error when starting the LabChip GX software. (LCF-5369) · Selecting a future ladder for a bracket ladder is now supported and displays a warning that the selection may result in poor sizing accuracy. This allows using bracketing ladders for the first row if the first ladder is bad. (LCF-5375) · If the Create Daily Subdirectory check box is selected, the paths in the AutoExport window can now be changed to a new folder, as long as the folder name is not a date. (LCF-5384) Known Issues: · The Size Scale units may overlap if the Electropherogram is printed in Portrait orientation. To avoid this issue, either zoom in on the region of interest before printing or print the egram in Landscape orientation. (LCF-5471) · The Version Log History may log changes to the bracket ladder alignment when the first modification is made to the analysis if the bracket ladder was not run completely or if the ladder was bad. (LCF-5475) LabChip GX V4.0 SP2: New Features: · Added LabChip GX DirectControl support for MultiDx Chips. (LCF-5365) LabChip GX V4.0 SP1: Resolved Issues: · Leading zeros are now supported when specifying the column number in the Well Label column of the Sample Name Editor. For example, Well A1 can be specified as A1, A01, or A001. (LCF-5339) · The names of auto-exported files now match the data file name when the auto-export settings are imported from a run file. (LCF-5349) · Resolved an issue with printing previous and current IQ/OQ reports that occurred if the IQ/OQ tests were run in a previous software version, the locale was changed to any locale other than English (United States), and then the software was updated to V4.0 or higher. Previous and current IQ/OQ reports can now be printed after the software has been upgraded. (LCF-5330) Known Issues: · If the locale was set to a locale other than English (United States) before installing an older version of the LabChip GX software and then the software is updated to V4.0 SP1, IQ reports run in the older LabChip GX software cannot be printed. If the locale is not English (United States), print IQ reports before upgrading the software. (LCF-5358) LabChip GX V4.0: New Features: · LabChip GX V4.0 supports the following new assays: 3 new CZE (HT Protein Charge Variant) assays and 2 new RNA Pico assays. · The Run tab on the Start Run window now contains Quadrant Select buttons (Q1, Q2, Q3, and Q4) to select or clear all of the wells in a specific quadrant of the plate. (LCF-5167) · The Excluded Peaks tab on the Assay Analysis window now includes an Exclude All option. When checked, all of the peaks in the specified range (Size +/- Window (%)) are excluded from the analysis. (LCF-5182) · The Optics Noise Test has been added to the Optics Tests in the Diagnostics Window. The Optics Noise Test uses Test Chip C to verify the signal noise is less than 1. (LCF-5239) · The Cypress Driver has been updated to V3.4.7. (LCF-5262) · The FTDI Driver has been updated to V2.08.24. (LCF-5199) · Removed the limit of 2000 samples from the HT DNA 1K/HS 5K/12K chip. The chip can now be used after the sample limit is exceeded. (LCF-5244) · The Chip Cartridge Interlock Test in System Diagnostics now verifies that the interlock is open when the cartridge is open. In previous versions, the interlock was only tested with the cartridge closed. (LCF-5191) Resolved Issues: · Special characters are now allowed and display properly in the Sample Name and User Comments fields of the Editors opened from the Well Table as well as the Sample Name Editor. (LCF-5030) · Smear Smoothing now applies to high intensity smears as well as for low intensity smears below 20 RFU. (LCF-5141) · The firmware now disconnects after 5 seconds without communication with the software. This could occur if the software crashes and brings the port router down without properly disconnecting. (LCF-5267) · The Print option now uses the sample colors selected in the Overlay Electropherogram tab. (LCF-5252) Known Issues: · Displaying data from different CZE assay types (68s, 90s, 110s) in the Overlay Electropherograms tab adjusts the time axis to match the first well added to the collection. Selecting a shorter assay first can result in displaying incomplete data for longer assays. Selecting a longer run first can result in displaying erroneous data after the stop time of shorter assays. (LCF-5322) · PDFCreator crashes when printing to PDF if the PDF Creator taskbar icon is opened and closed before printing the PDF. (LCF-5184) · If another version of PDFCreator is already installed, then PDFCreator displays a location unavailable error message when installing the GX software. Click OK in the error message window to clear the error. This issue does not affect the installation. (LCF-5326) · When printing the IQ reports, if the locale was changed on the computer (Eg: US English to UK English), you may not be able to print all older reports and a message may display that the software cannot print old reports from the previous version for which the locale was different. If IQ was not run in the V4.0 software and if the user tries to print an older report after changing the locale, then a message will show that there are no records to print. (LCF-5315) · In Windows 7, the Aero theme may cause dialogs to display as transparent with no options, text, or graphics displayed. To prevent this issue, use one of the Windows 7 Basic themes. To change the theme, right-click on the desktop, select Personalize, and then select any of the Basic themes. (LCF-5184) LabChip GX V3.1 SP1: Resolved Issues: · Resolved an issue where an impurity peak in the ladder can be misidentified as a ladder peak if the area of the impurity peak is larger than the area of the ladder peak. (LCF-5219) Known Issues: · In Windows 7, the Aero theme may cause dialogs to display as transparent with no options, text, or graphics displayed. To prevent this issue, use one of the Windows 7 Basic themes. To change the theme, right-click on the desktop, select Personalize, and then select any of the Basic themes. (LCF-5184) LabChip GX V3.1: New Features: · The Print window now contains a Multiple Electropherogram option to print multiple Electropherograms on the same page by specifying the desired number of graphs per row and per column on a page. (LCF-4313) · Print to PDF option is now available in the Print window. The Print to PDF button prints the selected options to a pdf file instead of to a printer. (LCF-2819) · The ability to Accept, Reject, and/or Lock a data file is now included in the Perform Signature window. The Approval State can now be set to Unreviewed, Accept, or Reject. Only accepted or rejected data files can be locked. Locked data files cannot be saved and the approval state cannot be changed. Only users with the Unlock permission can unlock data files. (LCF-4594) · The CDR Server Utility Window now includes a View Contents button to display the contents of the Remote CDR. The Login and Password for the Remote CDR must be entered to view the data files. Data files that are on the local computer but are not in the Remote CDR are flagged with an error icon. (LCF-4556) · The FWHM [BP] can now be added as a column in the Peak Table. (LCF-4647) · A Smear Baseline option is now available on the Advanced tab in the Assay Analysis Window. Select either Two Point or Peak Baseline option. (LCF-4641) · The Smear Start and Smear End properties are now available for view in the Well Table. These values represent the actual values shown on the graph, which may have been modified by the user from the original smear extents. The Smear CV[%] property is also available for view in the Well Table. (LCF-4670) · A Start Prime option is available on the Instrument menu to prime the chip before starting the run. (LCF-4778) · The Gel View Properties tab now includes a Show Peak Information option to specify whether to show a tool tip when hovering the cursor over a band in the gel. (LCF-4804) · The Graph View Properties tab for the Electropherograms tab and Overlay Electropherograms tab now provide two size options for the X axis scale. The Log Size option plots the size on a log scale and was called Size in previous software versions. The Size option replaces the uniform time marks on the graph with the corresponding (non-uniform) size without changing the data trace. (LCF-4832) · A Smear Smoothing option is now available on the Advanced tab in the Assay Analysis Window. Select Disabled to use the actual data signal or Spline to fit a spline curve to the data signal. The Threshold specifies how closely the curve follows the smear shape. (LCF-5091) · When the 21 CFR Part 11 option is installed, only users with the Perform Validation access rights can access the Calibrate Optics Window and Teaching Utility Window. (LCF-4769) Resolved Issues: · Resolved an issue where the LabChip GX software crashes at the Splash screen if the Current Location is set to a location where a comma is used as the decimal point. (LCF-4868) · Integration overrides are now applied to ladder peaks as well as sample peaks. (LCF-4847) · DNA assays of different types (i.e., DNA 1K/12K and DNA HiSens) can now be opened in the same workspace. (LCF-4831) · The Gel View, Graph View, and Properties tabs now display properly after the software is minimized, restored, and maximized in Windows 7 64-bit OS. (LCF-4783) · Expected Peak size and Size +/- Threshold values are both rounded to the correct decimal place before comparing the peak size to the EP window. (LCF-4692) · If Only Annotate Expected Peaks is selected in the Graph View Properties tab, manual peaks (MP) are no longer annotated in the graph. (LCF-4634) · Two Smear baseline options, Two Point or Peak Baseline are now available on the Advanced tab in the Assay Analysis window to properly calculate the Smear at Max property for shallow smears. (LCF-4632) · The Undo function for collections now works properly to undo changes to the collection view settings. (LCF-4555) · Resolved an issue where resetting a peak baseline would generate a “Peak infringes on Manual Peak” error. (LCF-4421) · Multiple peaks can now be added in the Filter tab without generating a “Null value not allowed” error. (LCF-4353) · Note to v3.0 Automation Interface users: The AutomationStatusEvent now correctly reports the status when a run terminates abnormally by returning the status code RUN_STOPPED_BY_USER or RUN_ABORTED. In GX 3.0, the AutomationStatusEvent would report STATUS_OK even if the run terminated abnormally. Customers may encounter a problem if their automation client was implemented to handle only the "STATUS_OK" returned state. In such cases, customers may have to modify their automation client to correctly process the additional status codes returned by the GX application. iLink Pro automation users will not experience any issues due to this change. Known Issues: · Smear Smoothing only works for low intensity smears below 20 RFU. (LCF-5141) · An unhandled error "The given key was not present in the dictionary" displays during the run if the data path is deleted or not accessible during priming/warming. This error may occur if the data path is a network path or a removable drive such as an external USB drive. To prevent this error, make sure the data path is accessible before beginning the run. (LCF-5124) · On Windows 7 SP1 64-bit systems, the plates in the Plate View flash when the cursor hovers over a peak in the Graph View if the software has been minimized and then restored or maximized. Restart the software to stop the Graph View from flashing. (LCF-5110) · Because the Overlay Offset in the Overlay Electropherograms tab persists when closing and opening the LabChip GX software, some signals may not display if the RFU values of the data differ significantly. Reset the Overlay Offset (in the Graph Properties tab) if the RFU value of the data changes significantly. (LCF-5107) · New smear properties are not displayed in the Well Table when updating existing smears. The new Smear Properties are only calculated for new smears. (LCF-5098) · An unhandled error “Index was outside the bounds of the array” displays when turning off analysis if a data file is missing when a workspace is loaded and the user opens a data file with a different type of plate (384-well instead of 96-well). Only open the same type of plate if a data file is missing in a workspace. (LCF-5013) · Previous Diagnostics Reports cannot be viewed if the Current Location and Date/Time Format Settings on the computer are changed. Leave the Current Location set to United States and the Date/Time format set to English (United States). (LCF-4971) · In Windows 7, dialogs may display as transparent with no options, text, or graphics displayed. To recover from this issue, hold the cursor over the LabChip icon in the Windows taskbar until the transparent dialog preview displays above the taskbar. Click the red X (Close) button above the dialog preview. If the dialog contains a Close option, the dialog closes. If the dialog does not have a Close option, the dialog displays correctly on the Windows 7 desktop. (LCF-4957) · Downgrading the software from LabChip GX V3.1 with 21 CFR Part 11 to LabChip GX V3.0 with 21 CFR Part 11 is not recommended due to the addition of the Lock feature in the GX V3.1 software. Data files that are locked in V3.1 will be editable in V3.0 software and the audit trail will show records of editing a locked data file. (LCF-4796) LabChip GX V3.0 SP3: New Features: · LabChip GX V3.0 SP3 in Reviewer Mode now runs on Windows 7 64-bit U.S. English version. (LCF-4694) · Priming Pressure Leak Rate Limit in Diagnostics lowered to 1.5 psi/min. (LCF-4744) · Firmware now supports USB 1.1. USB 2.0 support has been removed. (LCF-4794) Resolved Issues: · Instrument Qualification Test (IQ) no longer checks for the HT DNA 1K assay file. The HT DNA 1K assay was removed in V3.0 SP1. (LCF-4716) Known Issues: · CFR Mode - An Object Reference error may display when closing the software. The error usually closes automatically. (LCF-4790) · The Undo option is enabled after printing, even when no changes have been made to the collection. (LCF-4781) · Display problems may occur after minimizing and then restoring the LabChip GX software when using Windows 7 64-bit. The Gel View may not display, the Graph View may display outside the borders, the Plate View may flash when hovering over a peak in the graph, and the Properties tab may not display the entire text. Views can be restored by clicking the Auto-Hide button at the top right corner of the Properties window in the Gel View to unpin the window and then click again to pin the Properties window back in place. (LCF-4783) LabChip GX V3.0 SP2: New Features: · HT Protein LMW assay - Priming is now performed in four short steps instead of two long steps to avoid running out of range on the pump observed on some instruments. (LCF-4704) LabChip GX V3.0 SP1: New Features: · New HT Protein Express Low MW assay is now available. (LCF-4649) · HT DNA 5K Version 2 assay is included in the software and kits will be available soon (LCF-4678). · HT DNA 12K Version 2 assay is included in the software and kits will be available soon (LCF-4678). · HT DNA 12K Extended Time Version 2 assay is included in the software and kits will be available soon (LCF-4677). · Updated Plate List to include new plates and remove outdated plates. (LCF-4637) Resolved Issues: · Diagnostics Print now works correctly on LabChip GX instruments. Diagnostics Print continues to function properly on LabChip GXII instruments. (LCF-4646) · The lower limit of the Ladder Conc in the Analysis Settings window is now 0.05 for the HiSens assay. (LCF-4629) · Baseline property for all Protein assays (except LMW) had been changed from 10 to 11 seconds to avoid large signal transient which occurs between 9 and 10 seconds. (De-stain starts after 9 seconds, and the signal does not reach baseline until just before 10 seconds. Because this area is very noisy, the baseline algorithm has been using the end of the signal for the baseline instead.) . (LCF-4684) · Peak Find Start value in Protein LMW assay changed from 13 seconds to 14 seconds so peak find does not start until end of baseline region. (LCF-4693) · Negative peak sizes returns exception to caller instead of assertion failure which caller cannot catch. This change avoids assertion exception appearing during ladder analysis of bad ladders and instead results in analysis error reported in Well table. (LCF-4682) LabChip GX V3.0: New Features: · New DNA Hi Sensitivity assay is now available. (LCF-4590) · LabChip GX software is now compatible with Windows 7. (LCF-4609) · Default name of Export file now reflects the plate that contains the first selected wells in the collection. (LCF-4395) · The DNA 1K/Hi Sens/12K chip will not run after it exceeds the maximum samples limit. (LCF-4383) · Prompt user to remove and re-prime chip when changing assays. (LCF-4382) · Titer Concentration Weighting now displays numerical value above slider. (LCF-4378) · The Fit quality or R^2 value now shows after the fit coefficients. It is also reported on the Titer Print Report. (LCF-4377) · Shortcut to the LabChip GX User Manual is now created on the desktop during software installation. (LCF-4358) · Bracket ladder warnings now do not display during a run. After the plate is complete, any bracket ladder warnings will display if necessary. (LCF-4352) · A titer can now be created using one titer well and selecting the Force through Origin option. (LCF-4334) · When saving a workspace with multiple modified data files, Yes to All and No to All buttons are now provided to save all changed data files. (LCF-4332) · Print option is now available on the Titer Curve window. Prints the titer curve, titer parameters, and data table for area vs. concentration table. (LCF-4323) · Now can manually backup and restore CDR and SQL database. (LCF-4217) · Smear sizes can now be changed in the Graph View by clicking and dragging. (LCF-3843) · Can now type the well number into the Found in Well column on the Titer tab. (LCF-3735) · Assay Analysis now includes Rolling Ball baseline analysis. (LCF-3660) · Sample Editor now supports deleting entry after clicking the cell only once. (LCF-3449) · LabChip GX software now uses .NET 4 instead of .NET 3.5 SP1. (LCF-4512) · Expected peaks occurring before the Lower Marker are now supported. (LCF-4524) · Teaching Utility is now available in non-developer mode. (LCF-4531) · Synchronized zoom is now available on the right-click shortcut menu in the Graph view. (LCF-4527) · Marker Drift Tolerance parameter now available. (LCF-4526) Resolved Issues: · Analysis now consistently splits side lobes from main peak. (LCF-4590) · RNA data is no longer extended to prevent distorting RNA Area baseline. (LCF-4589) · Lowered signal noise for Glycan data. (LCF-4587) · Software IQ is not longer enabled for users without proper access level. (LCF-4591) · Corr. Area of smears now updates properly after dragging the smear baseline in Protein and Glycan assays. (LCF-4579) · Autofocus revised to perform the final slow x-scan at the final z location. (LCF-4438) · Corrected problem opening data file if data for a well was not written to the file. (LCF-4406) · Assay numbers of DNA 1K and DNA 12K assays are now unique when stored on the chip. User will now correctly be prompted to re-prime the chip when changing assays. (LCF-4384) · Barcode test results are now included in the Diagnostics report. (LCF-4367) · Data path in the Start Run window now displays the last directory used instead of reverting to the default. (LCF-4317) · Event Viewer window now stays on top until closed. (LCF-4099) · Auto Export now retains previous selections. (LCF-3846) · CFR mode now will not open non-CFR workspaces. (LCF-3779) · In 21 CFR Part 11 Compliance mode, the LabChip GX now only opens data files in the CDR (Central Data Repository) – Opening a workspace that contains data files that are not saved in the CDR generates an error message. Use a non-CFR version of the LabChip GX software to open non-CFR workspaces and data files. (LCF-3768, LCF-3767) · Resolved error in Chip ID when writing to RFTag – When writing to the RFTag, the first character of the Chip ID may be written as the first character of the previous chip if the RFTag was not read before writing. This issue has been resolved. (LCF-3818) Known Issues: Open Issues in LabChip GX V3.0: · The Undo option on the Collection menu is not functioning. (LCF-4555) · LabChip GX software does not connect to instrument if instrument is power-cycled while software is running. Close the software, power-cycle the instrument, and then restart the software to reconnect. (LCF-4532) · Titer Fit Conc is rounded to one decimal in the Assay Analysis window but is rounded to 2 decimals in the Titer report. (LCF-4502) · Changes to the User Comments in the Well Table that are made during a run are not logged to Version History the first time they are changed. Subsequent changes are logged to version history. (LCF-4458) · 'Peak infringes on manual peak' error message displays when resetting peak baseline, even when there are no manual peaks. (LCF-4421) · The menu option to scale to all/sample peaks is disabled for all wells after selecting an error well. (LCF-4399) · Software incorrectly displays a "Null value not allowed" error when adding multiple Expected Peaks to a filter. (LCF-4353) · In the Sample Name Editor, wells are displayed without any proper sequence after selecting "Order by Column" option and then closing and reopening the window. (LCF-3782) · Gel scale unit is not always displayed against the correct peak. (LCF-3739) · All viewers are hidden if the LabChip GX V2.2 software is minimized during the run. Do not minimize the software during a run. (LCF-3546) · Front panel buttons may not function after terminating the software using CalTaskClean. Restart the instrument or restart the LabChip GX software to reactivate the front panel buttons on the instrument. (LCF-1828) · Install can be started if software is running in Reviewer mode. Close software before inserting the Software Install CD. (LCF-4601) · Electropherogram goes out of synch with other viewers on selecting any well after zooming if the Synchronize Zoom option is selected in the Electropherogram. (LCF-4598) · An “Application stopped working” error displays when starting the LabChip GX software if it is already running in another Windows session. (LCF-4592) · Adding a manual peak during the run is not logged in Version History. (LCF-4580) · An unhandled exception occurs when launching the CDR Server Utility with a Non-Windows Firewall installed on the computer. (LCF-4568) Documentation Complete documentation is available in the LabChip GX.chm HTML Help file (accessible by selecting Helpŕ LabChip GX Help in the software) or in the LabChip GX User Manual.pdf. Copyright (c) 2008 - 2013, Caliper Life Sciences. All rights reserved. Support Contact Caliper Technical Support by phone, fax, or e- mail from 8AM to 5PM Eastern Standard Time. Telephone: 1-877-LABCHIP (1-877-522-2447), toll free Fax: (508) 435-3439 E-mail: technical.support@caliperLS.com Internet Address: http://www.perkinelmer.com