CITRIC ACID, [1,5-14C]-
ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes the
synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and
ATP as substrates and Mg2+ as a necessary cofactor. The
ACL-dependent synthesis of acetyl-CoA is thought to be an essential
step for the de novo synthesis of fatty acids and cholesterol. For
this reason, inhibition of ACL has been pursued as a strategy to
treat dyslipidemia and obesity.