Acetyl Coenzyme A

A combination of acetic acid and coenzyme A that is energy rich, Acetyl coenzyme A (AcCoA) is produced by many catabolic pathways and is the substrate for the tricarboxylic acid cycle, fatty acid biosynthesis, and other pathways. Acetyl coenzyme A or acetyl-CoA is an important molecule in metabolism, used in many biochemical reactions. Its main function is to convey the carbon atoms within the acetyl group to the citric acid cycle to be oxidized for energy production. Acetyl-CoA is produced during the second step of aerobic cellular respiration, pyruvate decarboxylation, which occurs in the matrix of the mitochondria. Acetyl-CoA then enters the citric acid cycle. Acetyl-CoA functions as a coenzyme in many biological acetylation reactions and is formed as an intermediate in the oxidation of carbohydrates, fats, and proteins. Acetyl-CoA is also an important component in the biogenic synthesis of the neurotransmitter acetylcholine. Application of [3H] Acetyl Coenzyme A can be found in: analytical biochemistry, brain research and neuroscience methods, biochemical pharmacology, etc. PerkinElmer offers Acetyl Coenzyme A, [Acetyl-3H]- in 50 and 250 uCi unit sizes, research grade and Cat Assay Grade, depending on your drug discovery and research needs.

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