ValiScreen GPCR Cell Lines

PerkinElmer has the largest collection of pharmacologically validated recombinant GPCR cell lines for GPCR research. Our ValiScreen cell lines are validated with saturation and competition binding, and approximately 30% of these protocols have been adapted for GTPϒS binding and functional studies.

We have the technology and instrument platform to address all GPCR targets, regardless of the receptor signaling pathway. These include the measurement of intracellular calcium, cAMP, phosphor-ERK and receptor gene expression. In addition we have the world's most comprehensive collection of radiolabelled ligands for binding studies, a solution for measuring GTPϒS binding and a comprehensive collection of microplates to support all of the above platforms.

Visit the cell lines, frozen cells & membranes product listing to understand the validation for each product.


Products

Adenosine

Stable recombinant cell line expressing the Adenosine, A2a receptor. Human recombinant, in HEK-293 ...  View more

Adrenergic

Stable recombinant cell line expressing the Adenosine, A2a receptor. Human recombinant, in HEK-293 ...  View more

Adrenomedullin

Stable recombinant cell line expressing the Adrenomedullin, CRLR + RAMP3 receptor. Human recombinant,...  View more

Angiotensin

Stable recombinant cell line expressing the Angiotensin, AT1 receptor. Human recombinant, in CHO-K1...  View more

Apelin

Stable recombinant cell line expressing the Apelin, APJ receptor. Human recombinant, in CHO-K1 host...  View more

Bombesin

Stable recombinant cell line expressing the Bombesin, BB2 receptor. Human recombinant, in CHO-K1 host...  View more

Bradykinin

Stable recombinant cell line expressing the Bradykinin, B2 receptor. Human recombinant, in CHO-K1 host...  View more

Calcitonin Gene Related Peptide

Stable recombinant cell line expressing the CGRP, CRLR + Ramp1 receptor. Human recombinant, in CHO-K1...  View more

Cannabinoid

Stable recombinant cell line expressing the Cannabinoid, CB2 receptor. Human recombinant, in CHO-K1...  View more

Chemoattractant

Stable recombinant cell line expressing the Chemoattractant, C3a receptor. Human recombinant, in CHO-K1...  View more

Chemokine

Stable recombinant cell line expressing the Chemokine, CCR2b receptor. Human recombinant, in CHO-K1...  View more

Cholecystokinin

Stable recombinant cell line expressing the Cholecystokinin, CCKA receptor. Human recombinant, in 1321N1...  View more

Corticotropin-Releasing Factor

Stable recombinant cell line expressing the Corticotropin-Releasing Factor, CRF1 receptor. Human recombinant,...  View more

Dopamine

Stable recombinant cell line expressing the Dopamine, D3 receptor. Human recombinant, in CHO-K1 host...  View more

Endothelin

Stable recombinant cell line expressing the Endothelin, ETB receptor. Human recombinant, in CHO-K1 ...  View more

Free Fatty Acid

Stable recombinant cell line expressing the Free Fatty Acid FFA1 (GPR40) receptor. Human recombinant,...  View more

GABA

Stable recombinant cell line expressing the GABA, GABAb1a/GABAb2 receptor. Human recombinant, in CHO-K1...  View more

Galanin

Stable recombinant cell line expressing the Galanin, Gal2 receptor. Human recombinant, in CHO-K1 host...  View more

Ghrelin

Stable recombinant cell line expressing the Ghrelin receptor. Human recombinant, in CHO-K1 host cell....  View more

Glucagon

Histamine

Leukotriene

MCH

Melanocortin

Melatonin

Metastin Receptor

Motilin

Muscarinic

Neurokinin

Neuromedin U

Neuropeptide

Neurotensin

N-Formyl Peptide

Nicotinic

Nociceptin

Opioid

Orexin

Prokineticin

Prolactin Releasing Peptide

Prostanoid

Purinergic

Mammalian cell lines stably expressing recombinant GPCRs have long been used as a source of receptors...  View more

Relaxin

Serotonin

Mammalian cell lines stably expressing recombinant GPCRs have long been used as a source of receptors...  View more

Somatostatin

Mammalian cell lines stably expressing recombinant GPCRs have long been used as a source of receptors...  View more

Tyroid Releasing Hormone

Urotensin

Vasopressin

Mammalian cell lines stably expressing recombinant GPCRs have long been used as a source of receptors...  View more